Background: This pilot study was carried out to determine whether Helicobacter pylori can be detected in normal colon or in association with colorectal neoplasia.

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This investigation considered a novel method of enhancing penetration of the topical photosensitizing agent methyl aminolevulinate (MAL) into nodular basal cell carcinomas (BCCs) using an oxygen pressure injection device. Oxygen pressure injection (OPI) is a method to drive compounds into skin using pressured oxygen. The study was an observer-blinded pilot of a single application of MAL to nBCCs, with or without the use of OPI. The BCCs were then excised at different time intervals (0-180 min) and the depth of penetration of the MAL examined using microscopic fluorescence photometry to detect the production of the naturally fluorescent active photosensitiser protoporphyrin IX (PpIX). A highly selective and homogeneous distribution of MAL-induced porphyrin fluorescence was seen in all nBCC tumors studied, and showed a high lesion-to-normal-tissue ratio with very little fluorescence in the surrounding normal tissue. Although it was difficult to compare quantitatively, as individual tumors in each of the different study groups varied, a definite trend of increase in relative tumor concentration of MAL-induced PpIX was observed over time, and this was enhanced when OPI was employed.

1990) Histopathology 16, 151-1 55 Immunostaining of antral gastrin cells is quantitatively increased in Hellobacter pylori gastritisThe amount of gastrin-like immunostaining in gastrin degrees of infection were immunostained for gastrin. (G) cells of the antral mucosa was quantified using a Twenty-five G cells from each patient were measured computer-assisted method of measuring immunoreacboth subjectively and by image analysis. Gastrin-like tion product. Biopsies from 2 5 patients without Helioimmunoreactivity was found to be significantly bacter-like organisms and 6 0 patients with varying increased in the presence of Heliobacter-like organisms.

No abstract