Helicobacter pylori and Peptic Ulcer – Role of Reactive Oxygen Species and Apoptosis

Parra-Cid, T.; Calvino-Fernández, Miryam; Gisbert, Javier P.

doi:10.5772/21968

Cited by 5 publications

(15 citation statements)

References 76 publications

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“…Therapeutic management of peptic ulcer depends on modulation of such factors, and on this basis, several classes of drugs had been introduced, like proton pump inhibitors and histamine receptor blockers as antiulcer agent [ 23 ]. Aggressive factors involved in the pathogenesis of gastric ulceration are induced by several kinds of stress, including ethanol, NSAIDs or H. pylori [ 24 ]. In this study, we used a model of absolute ethanol-induced gastric ulceration for the evaluation of the activity of NAC as an antiulcer compound.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of N-Acetylcysteine against ethanol-induced gastric ulcer: a pharmacological assessment in mice

Jaccob¹

2015

J Intercult Ethnopharmacol

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Aim:Since there is an increasing need for gastric ulcer therapies with optimum benefit-risk profile. This study was conducted to investigate gastro-protective effects of N-acetylcysteine (NAC) against ethanol-induced gastric ulcer models in mice.Materials and Methods:A total of 41 mice were allocated into six groups consisted of 7 mice each. Groups 1 (normal control) and 2 (ulcer control) received distilled water at a dose of 10 ml/kg, groups 3, 4 and 5 were given NAC at doses 100, 300 and 500 mg/kg, respectively, and the 6th group received ranitidine (50 mg/kg). All drugs administered orally once daily for 7 days, on the 8th day absolute ethanol (7 ml/kg) was administrated orally to all mice to induce the acute ulcer except normal control group. Then 3 h after, all animals were sacrificed then consequently the stomachs were excised for examination.Results:NAC administration at the tested doses showed a dose-related potent gastro-protective effect with significant increase in curative ratio, PH of gastric juice and mucus content viscosity seen with the highest dose of NAC and it is comparable with that observed in ranitidine group.Conclusion:The present findings demonstrate that, oral NAC shows significant gastro-protective effects comparable to ranitidine confirmed by anti-secretory, cytoprotective, histological and biochemical data, but the molecular mechanisms behind such protection are complex.

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Section: Discussionmentioning

confidence: 99%

Protective effect of N-Acetylcysteine against ethanol-induced gastric ulcer: a pharmacological assessment in mice

Jaccob¹

2015

J Intercult Ethnopharmacol

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“…H. pylori is a gram-negative microaerophilic bacterium that affect the mucous lining of the stomach, especially the antrum [6,7]. H. pylori infection may result in either developing gastric ulcer (70-90%) or duodenal ulcer (90%) or both [1,8].…”

Section: Introduction 11 Backgroundmentioning

confidence: 99%

“…H. pylori infection may result in either developing gastric ulcer (70-90%) or duodenal ulcer (90%) or both [1,8]. H. pylori infection occurs in the early stages of life, but remains asymptomatic, and can live with the affected individual for a long period of time until it is treated [7]. Common signs and symptoms identified with the infection among the young people includes nausea, vomiting, gnawing or burning abdominal pain, intestinal bleeding, gastric reflex, occasional fever, poor appetite, bloating abdomen, frequent burping, tiredness and weakness, and weight loss [5].…”

Section: Introduction 11 Backgroundmentioning

confidence: 99%

“…Due to the increased rate of antibiotic resistance in the eradication of H. pylori, recommendations have been made for the development, and the use of new vaccines to prevent the infection among young people [13,14]. Research seems to prove that the infection of H. pylori increases with age, and the rate of infection among the elderly is higher than the youngsters, therefore critical attention must be given to children since 80% of the infection usually occur in childhood which usually persist until adulthood [7].…”

Section: Introduction 11 Backgroundmentioning

confidence: 99%

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Helicobacter pylori Infection in Peptic Ulcer Disease among Young People

Weytey¹

2022

Peptic Ulcer Disease - What's New?

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Peptic Ulcer Disease (PUD) is a common chronic disease of the Gastrointestinal Tract (GIT) worldwide, affecting 87.4 million people with 257,500 mortality turnouts in the year 2015. PUD is a painful open sore that develops in the wall lining of the lower part of the esophagus, the stomach, or the duodenum. PUD has both internal and external causative factors, of which Helicobacter pylori (H. pylori) is a major role player, accounting for 70–95% of its prevalence rate globally. H. pylori infection is acquired generally during the younger ages of life with its various mode of transmission, and with a prevalence rate of 90% in some developing countries, but remains asymptomatic till later years in life. This chapter attempts to provide the overview of H. pylori infection among young people, since they differ from the elderly, in terms of its prevalence rate, its risk factors, its complication rate, its diagnostic tests and managements, and its higher rate of antibiotic resistance.

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“…The latter, produced by the reaction between nitric oxide and superoxide anion radical, is highly cytotoxic [3]. Some of these reactive species (hydroxyl radical, peroxynitrite anion) mediate lipid peroxidation processes with subsequent cell lysis and generation of cytotoxic products such as malondialdehyde and 4-hydroxynonenal [4,5]. Oxidative stress is also involved in the gastric ulcerations caused by ethanol, nonsteroidal anti-inflammatory drugs (NSAIDS) and cold restraint stress [6,7].…”

Section: Introductionmentioning

confidence: 99%

Vernonia kotschyana Roots: Therapeutic Potential via Antioxidant Activity

et al. 2014

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Abstract:The roots of Vernonia kotschyana Sch. Bip. ex Walp. (Asteraceae) are used in Malian traditional medicine in the treatment of gastroduodenal ulcers and gastritis. Since oxidative stress is involved in gastric ulceration, the aim of this study was to screen the root extracts for their in vitro antioxidant activity and phenolic content. The roots were OPEN ACCESSMolecules 2014, 19 19115 extracted successively with chloroform, ethyl acetate, ethanol and water. The antioxidant activity of root extracts was evaluated in both cell-free and cell-based assays. Their chemical characterization was performed by Fourier transform infrared spectroscopy (FT-IR) whereas the total phenolic content was determined by the Folin-Ciocalteu method. The ethyl acetate extract displayed the highest phenolic content and was found to be the most active in the free radical scavenging and lipid peroxidation inhibition assays; it also showed a high antioxidant activity in MCF-12F cells. This study suggests a potential use of the ethyl acetate extract of Vernonia kotschyana not only as an antioxidant agent in gastroduodenal ulcers and gastritis, but also in other disorders characterized by high levels of oxidative stress.

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Helicobacter pylori and Peptic Ulcer – Role of Reactive Oxygen Species and Apoptosis

Cited by 5 publications

References 76 publications

Protective effect of N-Acetylcysteine against ethanol-induced gastric ulcer: a pharmacological assessment in mice

Protective effect of N-Acetylcysteine against ethanol-induced gastric ulcer: a pharmacological assessment in mice

Helicobacter pylori Infection in Peptic Ulcer Disease among Young People

Vernonia kotschyana Roots: Therapeutic Potential via Antioxidant Activity

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