Helicobacter pylori: A Beneficial Gastric Pathogen?

Abadi, Amin Talebi Bezmin

doi:10.3389/fmed.2014.00026

Cited by 11 publications

(6 citation statements)

References 38 publications

(45 reference statements)

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“…During the last decades, several new virulence factors have been characterized; however, we have still not identified one specific H. pylori virulence factor that covers the whole disease spectrum ( 20 , 21 ). It is worthwhile mentioning that new rapid sequencing technology is providing accurate information about H. pylori genome and in depth gene structure ( 4 , 22 , 23 ), validating the present hypothesis about the association between H. pylori virulence factors and gastroduodenal diseases. As with H. pylori therapy, scientists are facing a new challenge in H. pylori virulence factors.…”

Section: Antibiotic Therapy Of H Pylori : Defeatesupporting

confidence: 80%

Helicobacter pylori: Emergence of a Superbug

Abadi

2014

Front. Med.

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Section: Antibiotic Therapy Of H Pylori : Defeatesupporting

confidence: 80%

Helicobacter pylori: Emergence of a Superbug

Abadi

2014

Front. Med.

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“…However, recent research has shown that their effect on human health is more complex. Surprisingly, some of these misunderstood bacterial species appear to offer protection against certain diseases, such as asthma and the gastroesophageal reflux disease [ 43 ]. Furthermore, these strains affect the metabolic functions of the body and protect against esophageal cancer.…”

Section: The Microbiota Of the Gastrointestinal Tractmentioning

confidence: 99%

About Functional Foods: The Probiotics and Prebiotics State of Art

Ballini

Charitos

Cantore³

et al. 2023

Antibiotics

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Poor diet, obesity and a sedentary lifestyle have a significant impact on natural microbiota disorders; specifically, the intestinal one. This in turn can lead to a multitude of organ dysfunctions. The gut microbiota contains more than 500 species of bacteria and constitutes 95% of the total number of cells in the human body, thus contributing significantly to the host’s resistance to infectious diseases. Nowadays, consumers have turned to purchased foods, especially those containing probiotic bacteria or prebiotics, that constitute some of the functional food market, which is constantly expanding. Indeed, there are many products available that incorporate probiotics, such as yogurt, cheese, juices, jams, cookies, salami sausages, mayonnaise, nutritional supplements, etc. The probiotics are microorganisms that, when taken in sufficient amounts, contribute positively to the health of the host and are the focus of interest for both scientific studies and commercial companies. Thus, in the last decade, the introduction of DNA sequencing technologies with subsequent bioinformatics processing contributes to the in-depth characterization of the vast biodiversity of the gut microbiota, their composition, their connection with the physiological function—known as homeostasis—of the human organism, and their involvement in several diseases. Therefore, in this study, we highlighted the extensive investigation of current scientific research for the association of those types of functional foods containing probiotics and prebiotics in the diet and the composition of the intestinal microbiota. As a result, this study can form the foundation for a new research path based on reliable data from the literature, acting a guide in the continuous effort to monitor the rapid developments in this field.

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“…In addition, accumulating evidence also suggests that H. pylori, as well as other species in the Helicobacter Genus (e.g. H. mustelae) may exert beneficial roles in obesity, childhood asthma, inflammatory bowel disease (IBD) and celiac disease among others [41][42][43][44]. As such, the result that Helicobacter (15.8-fold that of the control group) was increased is especially intriguing and the increased species remain to be further specified and functionally investigated in future studies.…”

Section: Comparisons Of Fecal Bacterial Communities In the Treatment mentioning

confidence: 99%

Enteral nutrition modulation with n-3 PUFAs directs microbiome and lipid metabolism in mice

Tao

Xing

et al. 2021

PLoS ONE

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Nutritional support using exclusive enteral nutrition (EEN) has been studied as primary therapy for the management of liver diseases, Crohn’s disease, and cancers. EEN can also increase the number of beneficial microbiotas in the gut, improve bile acid and lipid metabolism, and decrease the number of harmful dietary micro-particles, possibly by influencing disease occurrence and increasing immunity. This study investigated the effects of EEN-n-3 polyunsaturated fatty acids (3PUFAs) (EEN-3PUFAs) on the gut microbiome, intestinal barrier, and lipid or bile acid metabolism in mice. Metagenomic sequencing technology was used to analyze the effects of EEN-3PUFAs on the composition of gut microbiome signatures. The contents of short-chain fatty acids (SCFAs) and bile acids in the feces and liver of the mice were assayed by gas chromatography and ultra-high-pressure liquid chromatography/high-resolution tandem mass spectrometry, respectively. The levels of lipopolysaccharide (LPS) and D-lactic acid in the blood were used to assess intestinal permeability. The results indicated that EEN-3PUFAs could improve the composition of gut microbiome signatures and increase the abundance of Barnesiella and Lactobacillus (genus), Porphyromonadaceae, and Bacteroidia (species), and Bacteroidetes (phylum) after EEN-3PUFAs initiation. In addition, EEN-3PUFAs induced the formation of SCFAs (mainly including acetic acid, propionic acid, and butyric acid) and increased the intestinal wall compared to the control group. In conclusion, EEN-3PUFAs modulate the alterations in gut microbiome signatures, enhanced intestinal barrier, and regulated the fatty acid composition and lipid metabolism shifts and the putative mechanisms underlying these effects.

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Helicobacter pylori: A Beneficial Gastric Pathogen?

Cited by 11 publications

References 38 publications

Helicobacter pylori: Emergence of a Superbug

Helicobacter pylori: Emergence of a Superbug

About Functional Foods: The Probiotics and Prebiotics State of Art

Enteral nutrition modulation with n-3 PUFAs directs microbiome and lipid metabolism in mice

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