Helicobacter pylori: Emergence of a Superbug

Helicobacter pylori detection methods in complex samples: a mini-review

“…Electrochemical sensors have inherently better sensitivity, reproducibility and portability than other sensing methods. 8,19 Standard electrochemical sensor utilizes the well-know 3-electrode configuration: Working Electrode (WE), Counter Electrode (CE) and Reference Electrode (RE). WE and CE are surface-functionalized using the same nanomaterials for signal amplification.…”

“…12,17,19 Peng et al 12 2017 designed HP gold electroactive electrode labeled with β-cyclodextrin (β-CD) DNA as biosensor. 8 DPV technique were used to measure HP on the designed sensor that showed lower limit of detection as low as 0.15nM. 12 Electrochemical based sensing requires the use of potentiostat devices to perform electrical supply and signal analysis.…”

“…[5][6][7][8][9][10] Invasive and non-invasive tests have been proposed based on different properties and pathogenic behaviors of HP. [5][6][7][8][9][10] These tests have different factors that determine its suitability for use as HP diagnosis. 11 These factors can range from the host clinical status, cost, safety as well as sample preparation.…”

“…11,15 This antigen is produced by the human body as a response of HP infection. [5][6][7][8][9][10][11][12][13][14][15][16][17]14 HpSA can be found in blood serum, stool and saliva and can be tested using the conventional serological technique like enzyme-linked immunosorbent Assay (ELISA). 3,10,11 This test is considered to be simple enough and compatible with point of care devices but increasing number of studies start to question its reliability as it produces more false-negative results.…”

Time to Stop Helicobacter pylori, no Matter with Antibiotic, Probiotic or Vaccine

“…3-H. pylori infection should be considered as a major public health and hygiene concern, therefore, scientists can justify immediate elimination of the H. pylori in clinical practice. In other words, we should not discuss the risks and benefits of the treatment of H. pylori in symptomatic or asymptomatic subjects, since the only left question would be how to treat rather than whom to treat (10). Finally, in order to get rid of problematic reports of H. pylori colonization, clinicians' optimal goal should be complete bacterial elimination from clinical and environmental samples.…”