Height and risk of colorectal cancer: a meta-analysis

Song, Xinyuan; Gong, Xiu-Zhen; Zhang, Tong; Jiang, Wenjie

doi:10.1097/cej.0000000000000390

Cited by 17 publications

(8 citation statements)

References 37 publications

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“…A global meta-analysis reported that each 5-cm increase in height was associated with a RR of 1.04-fold in Western countries [13], and this positive association was also supported by a recent global review [62]. Some Asian research supported this conclusion.…”

Section: Non-modifiable Factorsmentioning

confidence: 73%

Prevalence and risk factors of colorectal cancer in Asia

et al. 2019

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habits, physical activity, smoking and alcohol consumption. About 25% of the CRC cases have a genetic predisposition, and 5% of CRC patients have inherited factors associated with its development. 5,6 Family history of CRC and the presence of common chronic conditions, such as metabolic syndrome and fatty liver, were among the key factors reported by existing literature. In a report from Continuous Update Project, 7 being physically active, consuming wholegrains, dairy products, foods containing dietary fiber and taking calcium supplements are protective factors against the risk of CRC. 8-11 On the contrary, consuming red or processed meat, consumption of alcoholic beverages, being overweight or obese, and being tall are the risk factors of CRC. 9,11-13 These factors associated with CRC were supported by a meta-analysis including 103 global cohort studies. 14 Recent studies emphasized that global variations in socioeconomic development, dietary habits, lifestyle factors, ethnicity and genetics might be drivers of its diverse epidemiology among different countries. The present review discusses the prevalence of CRC; its risk factors and validated models for risk stratification as developed in various countries.

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Section: Non-modifiable Factorsmentioning

confidence: 73%

Prevalence and risk factors of colorectal cancer in Asia

et al. 2019

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“…These trends are not restricted only to the Asian region. A global meta-analysis obtains a relative risk of 1.25 (1.18-1.32) for CRC with the highest vs lowest height[ 34 ]. Likewise, a prospective systematic review corroborates the idea where CRC’s risk multiply by 1.06 for every 5 kg/m 2 increase in BMI[ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Prediction of hereditary nonpolyposis colorectal cancer using mRNA MSH2 quantitative and the correlation with nonmodifiable factor

Tedjasaputra¹,

Hatta²,

Massi³

et al. 2021

WJGP

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BACKGROUND Hereditary non-polyposis colon cancer is a dominantly inherited syndrome of colorectal cancer (CRC), with heightened risk for younger population. Previous studies link its susceptibility to the DNA sequence polymorphism along with Amsterdam and Bethesda criteria. However, those fail in term of applicability. AIM To determine a clear cut-off of MSH2 gene expression for CRC heredity grouping factor. Further, the study also aims to examine the association of risk factors to the CRC heredity. METHODS The cross-sectional study observed 71 respondents from May 2018 to December 2019 in determining the CRC hereditary status through MSH2 mRNA expression using reverse transcription-polymerase chain reaction and the disease’s risk factors. Data were analyzed through Chi-Square, Fischer exact, t-test, Mann-Whitney, and multiple logistics. RESULTS There are significant differences of MSH2 within CRC group among tissue and blood; yet, negative for significance between groups. Through the blood gene expression fifth percentile, the hereditary CRC cut-off is 11059 fc, dividing the 40 CRC respondents to 32.5% with hereditary CRC. Significant risk factors include age, family history, and staging. Nonetheless, after multivariate control, age is just a confounder. Further, the study develops a probability equation with area under the curve 82.2%. CONCLUSION Numerous factors have significant relations to heredity of CRC patients. However, true important factors are staging and family history, while age and others are confounders. The study also established a definite cut-off point for heredity CRC based on mRNA MSH2 expression, 11059 fc. These findings shall act as concrete foundations on further risk factors and/or genetical CRC future studies.

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“…Models were adjusted for age (continuous; years), height (continuous; cm) [ 25 ], family history of cancer (yes, no), educational level (categorical; low, medium, and high), smoking (continuous; pack/year), BMI (continuous; kg/m 2 , [ 26 ]), physical activity (continuous; leisure [i.e. cycling, dancing], household [i.e.…”

Section: Methodsmentioning

confidence: 99%

Diet quality indices and gastrointestinal cancer risk: results from the Lifelines study

et al. 2021

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Objective To investigate the long-term association between four dietary quality indices and the risk of gastrointestinal (GI) cancer. Methods Baseline details of the dietary intake of participants, assessed by a single food frequency questionnaire from the prospective Lifelines population-based cohort were translated to diet quality scores using several dietary and dietary-lifestyle indices. Incident cases of GI cancer were then assessed by linkage to the Dutch nationwide histo-cytopathology registry. The association between GI cancer risk and diet quality (defined as higher quintiles on dietary indices compared to the first quintile) was assessed by multivariable Cox proportional hazard models. Results We included 72,695 participants aged 51.20 ± 8.71 years with a median follow-up to cancer diagnosis of 8 years (interquartile range 2 years). During follow-up, 434 colorectal cancers and 139 upper GI cancers were diagnosed. There was a significant reduction in colorectal cancer risk for high categories in the American Cancer Society (ACS) Index (hazard ratio 0.62; 95% CI 0.46–0.84). However, high dietary index scores were not associated with strong beneficial effects on upper GI cancer risk. Conclusion High quintiles on the ACS Index were associated with a significantly reduced risk of colorectal cancer. This index may be of use in a colorectal cancer prevention program.

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Height and risk of colorectal cancer: a meta-analysis

Cited by 17 publications

References 37 publications

Prevalence and risk factors of colorectal cancer in Asia

Prevalence and risk factors of colorectal cancer in Asia

Prediction of hereditary nonpolyposis colorectal cancer using mRNA MSH2 quantitative and the correlation with nonmodifiable factor

Diet quality indices and gastrointestinal cancer risk: results from the Lifelines study

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