Heat Stress-Induced DNA Damage

Kantidze, Omar L.; Velichko, Artem K.; Luzhin, Artem V; Razin, S. V.

doi:10.32607/20758251-2016-8-2-75-78

Cited by 101 publications

(89 citation statements)

References 49 publications

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“…This plesiomorphic form is made up of microscopic filaments known as protonema that are formed by chains of haploid cells 49 . A number of studies have shown that Physcomitrella efficiently renders homologous recombination-based error-free DNA damage repair, an attribute that is likely to confer adaptive advantage in high-temperature habitats that are generally associated with higher rates of DNA damage 73 . Together with a plausible vegetative/asexual lifestyle, error-free DNA damage repair capabilities can act to reduce genetic variability in Physcomitrella and, ultimately, slow down evolution via conservation of genomes 74,75 .…”

Section: Discussionmentioning

confidence: 99%

Microbiome and ecology of a hot spring-microbialite system on the Trans-Himalayan Plateau

Roy

Rameez

Haldar

et al. 2020

Sci Rep

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Little is known about life in the boron-rich hot springs of trans-Himalayas. Here, we explore the geomicrobiology of a 4438-m-high spring which emanates ~70 °C-water from a boratic microbialite called Shivlinga. Due to low atmospheric pressure, the vent-water is close to boiling point so can entropically destabilize biomacromolecular systems. Starting from the vent, Shivlinga's geomicrobiology was revealed along the thermal gradients of an outflow-channel and a progressivelydrying mineral matrix that has no running water; ecosystem constraints were then considered in relation to those of entropically comparable environments. the spring-water chemistry and sinter mineralogy were dominated by borates, sodium, thiosulfate, sulfate, sulfite, sulfide, bicarbonate, and other macromolecule-stabilizing (kosmotropic) substances. Microbial diversity was high along both of the hydrothermal gradients. Bacteria, eukarya and Archaea constituted >98%, ~1% and <1% of Shivlinga's microbiome, respectively. Temperature constrained the biodiversity at ~50 °C and ~60 °C, but not below 46 °C. Along each thermal gradient, in the vent-to-apron trajectory, communities were dominated by Aquificae/Deinococcus-Thermus, then Chlorobi/Chloroflexi/Cyanobacteria, and finally Bacteroidetes/Proteobacteria/Firmicutes. interestingly, sites of >45 °C were inhabited by phylogenetic relatives of taxa for which laboratory growth is not known at >45 °C. Shivlinga's geomicrobiology highlights the possibility that the system's kosmotrope-dominated chemistry mitigates against the biomacromolecule-disordering effects of its thermal water. The microbial ecologies of habitats that are hydrothermal, or hypersaline, have been well-characterized, and can give insights into the origins of early life on Earth 1-3. Both chaotrope-rich hypersaline brines and high-temperature freshwater systems can entropically disorder the macromolecules of cellular systems, and are in this way analogous as microbial habitats 4-7. Indeed, highly-chaotropic and hydrothermal habitats are comparable at various scales of biology: the biomacromolecule, cellular system, and functional ecosystem 8,9. Chaotropic, hypersaline habitats include the MgCl 2-constrained ecosystems located at the interfaces of some of the stratified deep-sea hypersaline brines and their overlying seawater. Biophysical, culture-based, and metagenomic studies of the steep haloclines found at these interfaces have revealed that macromolecule-disordering (chaotropic) activities of MgCl 2 not only determine microbial community composition, but also limit Earth's functional biosphere 5,7,10 in such locations, as in situ microbial communities stop functioning at 2.2-2.4 M MgCl 2

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Section: Discussionmentioning

confidence: 99%

Microbiome and ecology of a hot spring-microbialite system on the Trans-Himalayan Plateau

Roy

Rameez

Haldar

et al. 2020

Sci Rep

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“…Heat stress could induce DNA break and inhibit DNA replication. [26] Caspase-3 might be involved in the increased DNA damage observed in animal skeletal muscles. [27] The caspase-3 activity in SJBW first increased and then decreased over time in low-temperature treatment (Figure 3(b)).…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress involved in textural changes of sea cucumber Stichopus japonicus body wall during low-temperature treatment

Dong

Feng

et al. 2018

International Journal of Food Properties

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“…Environmental sources of stress such as extreme heat or cold, hypoxia, and oxidative stress have been shown to cause DNA damage in human cells [Gregory and Milner, 1994;Gafter-Gvili et al, 2013;Luoto et al, 2013;Neutelings et al, 2013;Kantidze et al, 2016]. These stresses have also been shown to cause mutagenesis at trinucleotide repeats, which are implicated in the development of neurodegenerative disorders via the alt-NHEJ DNA repair pathway [Chatterjee et al, 2015[Chatterjee et al, , 2016b.…”

Section: Environmental Stressesmentioning

confidence: 99%

Mechanisms of DNA damage, repair, and mutagenesis

Chatterjee

Walker

2017

Environ and Mol Mutagen

1,345

995

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Living organisms are continuously exposed to a myriad of DNA damaging agents that can impact health and modulate disease-states. However, robust DNA repair and damage-bypass mechanisms faithfully protect the DNA by either removing or tolerating the damage to ensure an overall survival. Deviations in this fine-tuning are known to destabilize cellular metabolic homeostasis, as exemplified in diverse cancers where disruption or deregulation of DNA repair pathways results in genome instability. Because routinely used biological, physical and chemical agents impact human health, testing their genotoxicity and regulating their use have become important. In this introductory review, we will delineate mechanisms of DNA damage and the counteracting repair/tolerance pathways to provide insights into the molecular basis of genotoxicity in cells that lays the foundation for subsequent articles in this issue.

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Heat Stress-Induced DNA Damage

Cited by 101 publications

References 49 publications

Microbiome and ecology of a hot spring-microbialite system on the Trans-Himalayan Plateau

Microbiome and ecology of a hot spring-microbialite system on the Trans-Himalayan Plateau

Oxidative stress involved in textural changes of sea cucumber Stichopus japonicus body wall during low-temperature treatment

Mechanisms of DNA damage, repair, and mutagenesis

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