Heat shock protein expression and injury optimization for laser therapy design

Rylander, Marissa Nichole; Feng, Yusheng; Bass, J. M.; Diller, Kenneth R.

doi:10.1002/lsm.20546

Cited by 35 publications

(35 citation statements)

References 38 publications

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“…Correlation of temperature history with cellular responses for short non-isothermal laser exposures has been a longstanding challenge. 3 Future surgical procedures will likely employ intraoperative thermal imaging 4 with feedback control of laser dose based on known cell-specific thermal damage kinetics 5,6 to ensure desired therapeutic effects. However, predicting cellular outcomes based on laser dose kinetics is inherently difficult.…”

Section: Introductionmentioning

confidence: 99%

Spatially correlated microthermography maps threshold temperature in laser-induced damage

Denton¹,

Noojin²,

Foltz³

et al. 2011

J. Biomed. Opt.

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Abstract. We measured threshold temperatures for cell death resulting from short (0.1-1.0 s) 514-nm laser exposures using an in vitro retinal model. Real-time thermal imaging at sub-cellular resolution provides temperature information that is spatially correlated with cells at the boundary of cell death, as indicate by post-exposure fluorescence images. Our measurements indicate markedly similar temperatures, not only around individual boundaries (single exposure), but among all exposures of the same duration in a laser irradiance-independent fashion. Two different methods yield similar threshold temperatures with low variance. Considering the experimental uncertainties associated with the thermal camera, an average peak temperature of 53 ± 2• C is found for laser exposures of 0.1, 0.25, and 1.0 s. Additionally, we find a linear relationship between laser exposure duration and time-averaged integrated temperature. The mean thermal profiles for cells at the boundary of death were assessed using the Arrhenius rate law using parameter sets (frequency factor and energy of activation) found in three different articles. C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).

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Section: Introductionmentioning

confidence: 99%

Spatially correlated microthermography maps threshold temperature in laser-induced damage

Denton¹,

Noojin²,

Foltz³

et al. 2011

J. Biomed. Opt.

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“…[23][24][25] Specifically, it is known that the thermal treatment of primary tumors can induce the release of unique tumor antigenic peptides that are bound to HSPs. [26][27][28][29] However, high levels of laser irradiation can lead to total tissue destruction and may hamper host immune response in the process. Therefore, laser-tissue interaction induced by LIT must be administered with proper guidance.…”

Section: Introductionmentioning

confidence: 99%

Assessment of thermal effects of interstitial laser phototherapy on mammary tumors using proton resonance frequency method

Figueroa

et al. 2011

J. Biomed. Opt.

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Abstract. Laser immunotherapy (LIT) uses a synergistic approach to treat cancer systemically through local laser irradiation and immunological stimulation. Currently, LIT utilizes dye-assisted noninvasive laser irradiation to achieve selective photothermal interaction. However, LIT faces difficulties treating deeper tumors or tumors with heavily pigmented overlying skin. To circumvent these barriers, we use interstitial laser irradiation to induce the desired photothermal effects. The purpose of this study is to analyze the thermal effects of interstitial irradiation using proton resonance frequency (PRF). An 805-nm near-infrared laser with an interstitial cylindrical diffuser was used to treat rat mammary tumors. Different power settings (1.0, 1.25, and 1.5 W) were applied with an irradiation duration of 10 min. The temperature distributions of the treated tumors were measured by a 7 T magnetic resonance imager using PRF. We found that temperature distributions in tissue depended on both laser power and time settings, and that variance in tissue composition has a major influence in temperature elevation. The temperature elevations measured during interstitial laser irradiation by PRF and thermocouple were consistent, with some variations due to tissue composition and the positioning of the thermocouple's needle probes. Our results indicated that, for a tissue irradiation of 10 min, the elevation of rat tumor temperature ranged from 8 to 11• C for 1 W and 8 to 15• C for 1.5 W. This is the first time a 7 T magnetic resonance imager has been used to monitor interstitial laser irradiation via PRF. Our work provides a basic understanding of the photothermal interaction needed to control the thermal damage inside a tumor using interstitial laser treatment. Our work may lead to an optimal protocol for future cancer treatment using interstitial phototherapy in conjunction with immunotherapy. C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).

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“…The spatiotemporal temperature distributions can be modeled and predicted using the Pennes's bioheat transfer equation [30,31]:…”

Section: Heat Transfer Equationmentioning

confidence: 99%

“…The Arrhenius injury model was used to predict the cell and tissue injury in the process of in vivo and in vitro bioimaging. The cell/tissue damage rate can be calculated as [24,31]:…”

Section: Heat Transfer Equationmentioning

confidence: 99%

Optically investigating Nd^3+-Yb^3+ cascade sensitized upconversion nanoparticles for high resolution, rapid scanning, deep and damage-free bio-imaging

Zhao¹,

Zhan²,

Liu³

et al. 2015

Biomed. Opt. Express

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Abstract:The rapid development of upconversion nanoparticles (UCNPs) has been facing with a great challenge: intense emission, fast scanning, and deep imaging require high-power light irradiation with minimized heating effect (the intrinsic 975-nm excitation of Yb 3+ -sensitized UCNPs have overheating problem). By shifting the excitation peak from 975 nm to 795 nm, Nd 3+ -Yb 3+ cascade sensitized upconversion nanoparticles (Nd-UCNPs) with minimized heating effect were reported as the new generation UCNPs. For the first time, within two optically modeled applications in vitro and in vivo, the damage outcomes under long time high power laser excitation were solidly calculated, complementing the damage-free study of Nd-UCNPs. The higher resolution (20% improvement) and five times faster scanning microscopy were successfully performed using Nd-UCNPs under safety laser power level. The computational results showed the Nd 3+ -Yb 3+ energy transfer efficiency would not compromise the deep imaging ability, and the red (650-nm) emission is worth to be enhanced for deep tissue imaging.

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Heat shock protein expression and injury optimization for laser therapy design

Abstract: Utilization of the treatment planning optimization model can permit more effective tumor destruction by mitigating tumor recurrence and resistance to chemotherapy and radiation arising from HSP expression and insufficient injury.

Cited by 35 publications

References 38 publications

Spatially correlated microthermography maps threshold temperature in laser-induced damage

Spatially correlated microthermography maps threshold temperature in laser-induced damage

Assessment of thermal effects of interstitial laser phototherapy on mammary tumors using proton resonance frequency method

Optically investigating Nd^3+-Yb^3+ cascade sensitized upconversion nanoparticles for high resolution, rapid scanning, deep and damage-free bio-imaging

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