Assessment of thermal effects of interstitial laser phototherapy on mammary tumors using proton resonance frequency method

Le, Kelvin; Li, Xiaosong; Figueroa, Daniel; Towner, Rheal A.; Garteiser, Philippe; Saunders, Debra; Smith, Nataliya; Liu, Hong; Hode, Tomas; Nordquist, Robert E.; Chen, Wei R.

doi:10.1117/1.3659200

Cited by 19 publications

(23 citation statements)

References 46 publications

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“…The temperature mapping results showed that the selective laser photothermal effect could increase tumor temperatures in a range of 10 to 25°C [83]. In a study by Le et al, different power settings (1.0, 1.25, and 1.5 W) were applied for 10 min in a rat tumor, demonstrating an increase in temperature that ranged from 8°C to 15°C based on different laser power and distance from the injected optical fiber [84]. …”

Section: Mechanism Of Incvaxmentioning

confidence: 99%

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InCVAX – A novel strategy for treatment of late-stage, metastatic cancers through photoimmunotherapy induced tumor-specific immunity

Zhou

Naylor³

et al. 2015

Cancer Letters

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A novel, promising potential cancer vaccine strategy was proposed to use a two-injection procedure for solid tumors to prompt the immune system to identify and systemically eliminate the primary and metastatic cancers. The two-injection procedure consists of local photothermal application on a selected tumor intended to liberate whole cell tumor antigens, followed by a local injection of an immunoadjuvant that consists of a semi-synthetic functionalized glucosamine polymer, N-dihydro-galacto-chitosan (GC), which is intended to activate antigen presenting cells and facilitate an increased uptake of tumor antigens. This strategy is thus proposed as an in situ autologous cancer vaccine (inCVAX) that may activate antigen presenting cells and expose them to tumor antigens in situ, with the intention of inducing a systemic tumor specific T-cell response. Here, the development of inCVAX for the treatment of metastatic cancers in the past decades are systematically reviewed. The antitumor immune responses of local photothermal treatment and immunological stimulation with GC are also discussed. This treatment approach is also commonly referred to as laser immunotherapy (LIT).

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Section: Mechanism Of Incvaxmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

InCVAX – A novel strategy for treatment of late-stage, metastatic cancers through photoimmunotherapy induced tumor-specific immunity

Zhou

Naylor³

et al. 2015

Cancer Letters

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“…LIT employs an in situ light absorbing dye to selectively enhance photothermal effect. Accurate determination of target tissue temperature is essential in understanding and optimizing the photothermal effect of LIT [7][8].…”

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confidence: 99%

Monitoring tissue temperature for photothermal cancer therapy based on photoacoustic imaging: a pilot study

Liu

et al. 2013

SPIE Proceedings

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In this study, we proposed photoacoustic imaging to monitor the temperature increase during photothermal therapy, which was carried out by utilizing a continuous wave laser and photoabsorber-enhanced black ink with a absorption peak in the near-infrared optical range. A focusing photoacoustic imaging is interfaced with a nanosecond pulsed laser to image tissue-mimicking phantoms before and after laser irradiation. The results demonstrated that changes in the photoacoustic signal could reflect temperature changes in tissue. More importantly, photoacoustic signal could be used to determine the temperature at the boundary of photoabsorber-enhance tissue during photothermal irradiation. Thus, the photoacoustic imaging could potentially become an effective tool to guide photoabsorber-enhanced photothermal therapy. Downloaded From: http://proceedings.spiedigitallibrary.org/ on 06/25/2016 Terms of Use: http://spiedigitallibrary.org/ss/TermsOfUse.aspx Late-stage, metastatic cancers pose a great challenge in cancer treatment. Laser immunotherapy (LIT), proposed in 1997 by Chen and co-workers [1], has shown to be a promising treatment modality for metastatic cancers in both pre-clinical and clinical studies [2-6]. Photothermal effect is a crucial component of LIT, by destroying tumor cells and releasing tumor antigens. LIT employs an in situ light absorbing dye to selectively enhance photothermal effect. Accurate determination of target tissue temperature is essential in understanding and optimizing the photothermal effect of LIT [7-8].Recent reports [9][10][11] demonstrated that the photoacoustic (PA) imaging could be used for monitoring tissue temperature. Furthermore, absorbing dye not only enhances the photothermal effect for cancer therapy, but also enhances the photoacoustic images of tissue.In this study, we proposed photoacoustic imaging to monitor the temperature changes in target tissue during photothermal therapy, using a continuous wave laser and a photoabsorber-enhanced black ink to enhance the light absorption by the target tissue. A focusing photoacoustic imaging is employed to image tissue-mimicking phantoms before and after laser irradiation for photothermal therapy. MATERIALS AND METHODS SamplesA black ink-containing gelatin phantom was constructed to simulate photoabsorber-enhanced target tumor tissue. The target gel was buried inside the homogeneous turbid medium. The phantom was made of Agar gel with intralipid as scatterers and black ink as absorbers. The homogeneous background contained 2 g Agar power, 2 ml intralipid-20% solution (Sino-Swed Pharmaceutical Corp. Ltd) and 100 ml distilled water. The cylindrical absorbing target was made of Agar gel (2 g Agar power and 50 ml distilled water) with 0.4ml black ink and 5ml intralipid-20% solution. The diameter of absorbing target is 1 cm. Experimental set-upThe photoacoustic system used for this study is described in detail in our previous publication [12].Instead of backward detection mode, the forward detection mode was employed, as shown in Figure 1.In...

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“…And temperature measurement based on water proton resonance frequency (PRF) in MRT has been used for interstitial laser therapy. 15,16 MRT provided noninvasive three-dimensional temperature distribution with high sensitivity. However, it had relatively low temporal resolution and its cost and complexity severely limited its practical applications.…”

Section: Introductionmentioning

confidence: 99%

“…Current noninvasive methods to measure tissue temperature include infrared thermography, [11][12][13] ultrasound thermograph, 14 and magnetic resonance thermometry (MRT). [15][16][17] Infrared thermography could provide sensitive and real-time detection. However, it can only measure surface temperature.…”

Section: Introductionmentioning

confidence: 99%

Interstitial photoacoustic technique and computational simulation for temperature distribution and tissue optical properties in interstitial laser photothermal interaction

Chen

Zhou

et al. 2017

J. Innov. Opt. Health Sci.

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Interstitial laser immunotherapy (ILIT) is designed to use photothermal and immunological interactions for treatment of metastatic cancers. The photothermal e®ect is crucial in inducing anti-tumor immune responses in the host. Tissue temperature and tissue optical properties are important factors in this process. In this study, a device combining interstitial photoacoustic (PA) technique and interstitial laser photothermal interaction is proposed. Together with computational simulation, this device was designed to determine temperature distributions and tissue optical properties during laser treatment. Experiments were performed using ex-vivo porcine liver tissue. Our results demonstrated that interstitial PA signal amplitude was linearly dependent on tissue temperature in the temperature ranges of 20-60 C, as well as 65-80 C, with a di®erent slope, due to the change of tissue optical properties. Using the directly measured temperature in the tissue around the interstitial optical¯ber di®usion tip for calibration, the theoretical temperature distribution predicted by the bioheat equation was used to extract optical properties of tissue. Finally, the three-dimensional temperature distribution was simulated to guide tumor destruction and immunological stimulation. Thus, this novel device and method could be used for monitoring and controlling ILIT for cancer treatment.

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Assessment of thermal effects of interstitial laser phototherapy on mammary tumors using proton resonance frequency method

Cited by 19 publications

References 46 publications

InCVAX – A novel strategy for treatment of late-stage, metastatic cancers through photoimmunotherapy induced tumor-specific immunity

InCVAX – A novel strategy for treatment of late-stage, metastatic cancers through photoimmunotherapy induced tumor-specific immunity

Monitoring tissue temperature for photothermal cancer therapy based on photoacoustic imaging: a pilot study

Interstitial photoacoustic technique and computational simulation for temperature distribution and tissue optical properties in interstitial laser photothermal interaction

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