Hearing impairment is associated with cognitive decline, brain atrophy and tau pathology

Wang, Hui-Fu; Zhang, Wei; Rolls, Edmund T.; Li, Yuzhu; Wang, Linbo; Ma, Ya‐Hui; Kang, Jujiao; Feng, Jianfeng; Yu, Jin‐Tai; Cheng, Wei

doi:10.1016/j.ebiom.2022.104336

Cited by 26 publications

(24 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies on hearing and HV were mostly based on the decline of hearing function. 28,29 Second, the hippocampus is involved in vestibular compensatory mechanisms, 30 as described in Hong et al, 9 for example, who investigated bilateral hippocampal gray matter volume expansion during vestibular compensation in patients with vestibular neuritis.…”

Section: Discussionmentioning

confidence: 99%

“…The dynamic flexibility of the brain allows it to incorporate and react to new information in real‐time and to rebalance or form new neural connections to adapt to new circumstances, 27 which indirectly supports our viewpoint. Previous studies on hearing and HV were mostly based on the decline of hearing function 28,29 . Second, the hippocampus is involved in vestibular compensatory mechanisms, 30 as described in Hong et al, 9 for example, who investigated bilateral hippocampal gray matter volume expansion during vestibular compensation in patients with vestibular neuritis.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Late‐Stage Meniere's Disease and Vestibular Functional Impairment on Hippocampal Atrophy

Jian

Wang

et al. 2023

The Laryngoscope

View full text Add to dashboard Cite

ObjectiveWe investigated correlations among clinical features, degree of inner ear endolymphatic hydrops (EH), and hippocampal volume (HV) in different stages of Meniere's disease (MD).MethodsFrom February 2021 to April 2022, clinical data were collected from 99 patients (39 males, 60 females, mean age: 50.4 ± 10.0 [range: 26–69] years) with unilateral MD admitted to the Department of Vertigo Disease of Shandong ENT Hospital. The left and right ears were affected in 64 and 35 patients, respectively. There were 50 and 49 cases in early (Stages 1, 2) and late stages (Stages 3, 4), respectively. Fifty healthy participants were included as controls. Audiovestibular function test results, EH grading using gadolinium‐enhanced magnetic resonance imaging (MRI), and HV determined on MRI were analyzed for patients at different stages of MD.ResultsBetween‐group comparisons of early and late MD revealed significant differences in the disease course, vestibular function (VF), degree of EH, and HV. There were no significant between‐group differences based on age, sex, affected side, subjective degree of dizziness, hospital anxiety, or depression. Mean HV in patients with early‐stage MD was correlated with the canal paresis value of the caloric test and pure tone hearing threshold, HV in late‐stage patients was correlated with vestibular EH.ConclusionPatients with late‐stage MD exhibited severe auditory and VF impairments, increased EH, and atrophy of the HV. More advanced disease was associated with greater vestibular damage and degree of EH.Level of Evidence3 Laryngoscope, 2023

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of Late‐Stage Meniere's Disease and Vestibular Functional Impairment on Hippocampal Atrophy

Jian

Wang

et al. 2023

The Laryngoscope

View full text Add to dashboard Cite

show abstract

“…In contrast to the gain of hair cells, SGN, cochlear nuclei and the auditory system, we also have a decline of sensory and neuron losses that will reduce the sound input [ 10 , 11 ]. Hearing deficits will likely affect close to one billion people [ 12 ] who are living with Alzheimer’s disease [ 13 , 14 , 15 ]. Likewise, the associated epibranchial placode that gives rise to distinct neuron development [ 16 , 17 ] can lose the sensory cells of taste in aging people [ 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Early Steps towards Hearing: Placodes and Sensory Development

Zine

Fritzsch

2023

IJMS

View full text Add to dashboard Cite

Sensorineural hearing loss is the most prevalent sensory deficit in humans. Most cases of hearing loss are due to the degeneration of key structures of the sensory pathway in the cochlea, such as the sensory hair cells, the primary auditory neurons, and their synaptic connection to the hair cells. Different cell-based strategies to replace damaged inner ear neurosensory tissue aiming at the restoration of regeneration or functional recovery are currently the subject of intensive research. Most of these cell-based treatment approaches require experimental in vitro models that rely on a fine understanding of the earliest morphogenetic steps that underlie the in vivo development of the inner ear since its initial induction from a common otic–epibranchial territory. This knowledge will be applied to various proposed experimental cell replacement strategies to either address the feasibility or identify novel therapeutic options for sensorineural hearing loss. In this review, we describe how ear and epibranchial placode development can be recapitulated by focusing on the cellular transformations that occur as the inner ear is converted from a thickening of the surface ectoderm next to the hindbrain known as the otic placode to an otocyst embedded in the head mesenchyme. Finally, we will highlight otic and epibranchial placode development and morphogenetic events towards progenitors of the inner ear and their neurosensory cell derivatives.

show abstract

“…Hearing loss is the most prevalent sensorial deficit, with a major impact on health perception. Depending on the age of onset, hearing loss, if not rehabilitated, has been linked to different disabilities, such as impaired language development in children and impaired interpersonal relationships, academic performances, social lives, and career opportunities, and even to cognitive decline in older adults [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…Nowadays, the term primary mitochondrial disorders (PMDs) describe, in the literature, a heterogeneous group of conditions related to defects of mitochondrial DNA (mtDNA) and/or of nuclear DNA (nDNA) encoding for structural mitochondrial subunits, causing disorders of the mitochondrial respiratory chain [ 7 , 8 ]. Compared to nDNA, mtDNA mutations are 10–100 times more frequent [ 1 ]. Furthermore, different proportions of mutant and wild-type mtDNA might coexist in the same cell, defining a condition called heteroplasmy.…”

Section: Introductionmentioning

confidence: 99%

The Role of Primary Mitochondrial Disorders in Hearing Impairment: An Overview

Fancello

Palma

et al. 2023

Medicina

View full text Add to dashboard Cite

Background. Defects of mitochondrial DNA (mtDNA) involved in the function of the mitochondrial electron transport chain can result in primary mitochondrial diseases (PMDs). Various features can influence the phenotypes of different PMDs, with relevant consequences on clinical presentation, including the presence of hearing impairment. This paper aims to describe the hearing loss related to different PMDs, and when possible, their phenotype. Methods. A systematic review was performed according to PRISMA guidelines, searching Medline until December 2022. A total of 485 papers were identified, and based on specified criteria, 7 were included in this study. Results. A total of 759 patients affected by PMDs and hearing loss were included. The age of patients ranged from 2 days to 78 years old, and the male-to-female ratio was 1.3:1. The percentage of subjects affected by hearing loss was 40.8%, (310/759), and in most cases, hearing impairment was described as sensorineural, bilateral, symmetrical, and progressive, with different presentations depending on age and syndrome severity. Conclusions. PMDs are challenging conditions with different clinical phenotypes. Hearing loss, especially when bilateral and progressive, may represent a red flag; its association with other systemic disorders (particularly neuromuscular, ocular, and endocrine) should alert clinicians, and confirmation via genetic testing is mandatory nowadays.

show abstract

Hearing impairment is associated with cognitive decline, brain atrophy and tau pathology

Cited by 26 publications

References 53 publications

Effect of Late‐Stage Meniere's Disease and Vestibular Functional Impairment on Hippocampal Atrophy

Effect of Late‐Stage Meniere's Disease and Vestibular Functional Impairment on Hippocampal Atrophy

Early Steps towards Hearing: Placodes and Sensory Development

The Role of Primary Mitochondrial Disorders in Hearing Impairment: An Overview

Contact Info

Product

Resources

About