Healthy aging and age-adjusted nutrition and physical fitness

Hammar, Mats; Östgren, Carl Johan

doi:10.1016/j.bpobgyn.2013.01.004

Cited by 29 publications

(22 citation statements)

References 84 publications

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“…Preservation of hormonal balance is the key to proper functioning of various physiological activities during the course of healthy aging. A large body of epidemiological evidence indicates that eating a diet rich in vitamins has numerous health benefits, as well as protective effects on the development of diseases, and results in increased longevity (Hammar and Ostgren, 2013; Park et al, 2012; Thomas, 2006). One such category of vitamins, vitamin A (retinol) and its derivatives, notably RAs (collectively referred to as retinoids), have antioxidant properties, and play unique modulatory and integrative roles across multiple metabolic and physiological processes (Bikle, 2012; Clagett-Dame and Knutson, 2011; Das et al, 2014; Manna et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Up-regulation of steroid biosynthesis by retinoid signaling: Implications for aging

Manna

Stetson

Daugherty

et al. 2015

Mechanisms of Ageing and Development

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Retinoids (vitamin A and its derivatives) are critical for a spectrum of developmental and physiological processes, in which steroid hormones also play indispensable roles. The StAR protein predominantly regulates steroid biosynthesis in steroidogenic tissues. We reported that regulation of retinoid, especially atRA and 9-cis RA, responsive StAR transcription is largely mediated by an LXR-RXR/RAR heterodimeric motif in the mouse StAR promoter. Herein we demonstrate that retinoids are capable of enhancing StAR protein, P-StAR, and steroid production, in granulosa, adrenocortical, glial, and epidermal cells. Whereas transient expression of RARα and RXRα enhanced 9-cis RA-treated StAR gene transcription, silencing of RXRα with siRNA, decreased StAR and steroid levels. An oligonucleotide probe encompassing an LXR-RXR/RAR motif bound to adrenocortical and epidermal keratinocyte NEs in EMSAs. ChIP studies revealed association of RARα and RXRα with the StAR proximal promoter. Further studies demonstrated that StAR mRNA levels decreased in diseased and elderly men and women skin tissues and that atRA could restore steroidogenesis in epidermal keratinocytes of aged individuals. These findings provide novel insights into the relevance of retinoid signaling in the up-regulation of steroid biosynthesis in various target tissues, and indicate that retinoid therapy may have important implications in age-related complications and diseases.

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Section: Discussionmentioning

confidence: 99%

Up-regulation of steroid biosynthesis by retinoid signaling: Implications for aging

Manna

Stetson

Daugherty

et al. 2015

Mechanisms of Ageing and Development

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“…Egzersiz, soluk alıp verme hızını, derinliğini ve kalp atış hızını belirli bir oranda artıran, az da olsa terlemeye yol açan, kollar ve bacaklar gibi büyük kas gruplarıyla yapılan bazal düzeyin üzerinde enerji harcamayı gerektiren bedensel hareketlerdir 8,9 . Her geçen gün insan sağlığında egzersizin rolü ile ilgili yayınlar artmakta ve bazı hastalıkların önlenmesinde, kardiovasküler hastalık, osteoporozis, bazı kanserler ve bazı mental bozukluklar 10 tedavisinde ve hatta yaşlılığın geciktirilmesinde egzersizin oynadığı rol daha belirgin hale gelmektedir 11. Yaşlanma; kas kaybı, fiziksel hareketsizlik ve güçsüzlüğün artmasıyla karakterize olmaktadır 12 . Sağlıklı diyet ve egzersiz alışkanlığı, sağlıklı yaşlanmaya katkıda bulunarak egzersizin oynadığı rolün önemini ortaya koymaktadır.…”

Section: Introductionunclassified

Examinat?on of healthy lifestyle attitudes of physical education and sports teaching department students

Sivrikaya¹,

Sivrikaya²,

Altun³

2013

BSBD

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METHODS:This research was a descriptive study. The study population and sample consisted of 195 volunteer students at 1st, 2nd, 3rd. and 4th year grades at Ataturk University School of Physical Education and Sports School Teaching programs from October to December 2005. Data was collected by using, personal questionnaire developed by the researchers and, "Healthy Lifestyle Behaviors Scale" (HLSB). Data was analyzed with t-test, analysis of variance and Tukey's HSD by using SPSS program versions 11.5 RESULTS: Investigation of the body mass index revealed that 7.7% of the students were lean, 83.6% of them were defined to be normal, % 8.7 of them were found to be fat. When body mass index was analyzed with respect to gender, 23.7% of female students and 0.7% of male students were lean. In general, 76.3% of female students and 86.8% of male students had a normal body mass index. None of the female students in the class was fat. In contrast, 12.5% of male students were considered as fat. The total HLSB was found as a mean of 126.9 ±20.92. CONCLUSION: Level of income, BMI and alcohol habit could be said to be effective for healthy lifestyle behavior. HLSB scores indicated that the students' knowledge for the health lifestyle behavior was slightly good. Based on these results, additional course covering the protection of health and awareness of students in this matter could be recommended at the curriculum of Physical Education and Sport Schools.

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“…To date, studies focus primarily on the healthy aging perceptions of policy-makers (Health Canada, 2002): researchers (Potempa, Butterworth, Flaherty-Robb, & Gaynor, 2010); and health professionals (Hammer & Östgren, 2013). In 2006, a background paper entitled "Healthy Aging in Canada" (Federal, Provincial and Territorial Committee Seniors, 2006) was developed to provide a vision for healthy aging by focusing on five areas for action including social connectedness, physical activity, healthy eating, falls prevention, and tobacco control.…”

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confidence: 99%