Up-regulation of steroid biosynthesis by retinoid signaling: Implications for aging

Manna, Pulak R.; Stetson, Cloyce L.; Daugherty, Carol; Shimizu, Ikue; Syapin, Peter J.; Garrel, Ghislaine; Cohen‐Tannoudji, Joëlle; Huhtaniemi, Ilpo; Slominski, Andrzej; Pruitt, Kevin; Stocco, Douglas M.

doi:10.1016/j.mad.2015.08.007

Cited by 34 publications

(31 citation statements)

References 85 publications

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“…RA plays a role in activating RARs and RXRs, steroid thyroid hormone receptor transcription factors. In 2015, it was reported that RA may restore steroidogenesis in epidermal keratinocytes of aged individuals [ 19 ]. Additionally, retinol increases epidermal thickness by upregulation of transcription factors, collagen genes responsible for wound healing, improving extracellular matrix microenvironment, extracellular matrix production, and activating dermal fibroblasts [ 20 , 21 ].…”

Section: Resultsmentioning

confidence: 99%

Consequences of Inadequate Intakes of Vitamin A, Vitamin B12, Vitamin D, Calcium, Iron, and Folate in Older Persons

2018

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Purpose of ReviewThis review broadly discusses the consequences of inadequate consumption, by deficit or excess, of selected micronutrients on the quality of life and morbidity during aging, specifically considering increases in life expectancy and the costs of care in the older persons.Recent FindingsA literature review of the periods 2012 to 2018, focusing on vitamins A, B12, and D, calcium, iron and folate, was completed as these micronutrients are found to significantly affect the aging process. Causation and application of these micronutrients to disorders related to aging are controversial and mixed. This review highlights research needs and controversial points on the role of these micronutrients.SummaryMicronutrient deficiencies are a common and avoidable contributor to decreased quality of life and healthcare costs in the older persons. Further research is needed to determine adequate intakes and innovative uses, including appropriate thresholds for improved health outcomes for this population.

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Section: Resultsmentioning

confidence: 99%

Consequences of Inadequate Intakes of Vitamin A, Vitamin B12, Vitamin D, Calcium, Iron, and Folate in Older Persons

2018

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“…Retinoid-responsive StAR transcription is largely regulated by an RXR/RAR heterodimeric motif in the mouse StAR promoter [ 79 ]. Moreover, retinoid receptors are capable of increasing the expression of the StAR protein [ 80 ], and RXRα interacts directly with GATA-4 [ 81 ]. In the present study, both RORαandGATA-4 were expressed in the goat testis in an age-dependent manner.…”

Section: Discussionmentioning

confidence: 99%

Melatonin up-regulates the expression of the GATA-4 transcription factor and increases testosterone secretion from Leydig cells through RORα signaling in anin vitrogoat spermatogonial stem cell differentiation culture system

Deng

Zhang

et al. 2017

Oncotarget

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Because androgen function is regulated by its receptors, androgen-androgen receptor signaling is crucial for regulating spermatogenesis. Androgen is mainly testosterone secreted by testis. Based on the results of early studies in goats, the administration of melatonin over an extended period of time increases steroid production, but the underlying mechanism remains unclear. Here, we report the expression of the melatonin membrane receptors MT1 and MT2 and the retinoic acid receptor-related orphan receptor-alpha (RORα) in the goat testis. An in vitro differentiation system using spermatogonial stem cells (SSCs) cultured in the presence of testicular somatic cells was able to support the formation of sperm-like cells with a single flagellum. The addition of 10-7 M melatonin to the in vitro culture system increased RORα expression and considerably improved the efficiency of haploid cell differentiation, and the addition of the RORα agonist CGP52608 significantly increased the testosterone concentration and expression of GATA binding factor 4 (GATA-4). Furthermore, inhibitors of melatonin membrane receptors and a RORα antagonist (T0901317) also led to a considerable reduction in the efficiency of haploid spermatid formation, which was coupled with the suppression of GATA-4 expression. Based on these results, RORα may play a crucial role in enhancing melatonin-regulated GATA-4 transcription and steroid hormone synthesis in the goat spermatogonial stem cell differentiation culture system.

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“…The larger the dots, the greater the number of genes that are significantly differentially expressed. mitochondria (Manna et al, 2015). To determine whether IL-6…”

Section: Il-6 Expression Was Upregulated In Facamentioning

confidence: 99%

Interleukin‐6 increases adrenal androgen release by regulating the expression of steroidogenic proteins in NCI‐H295R cells

Xian

Zhang

Peng

et al. 2020

Journal Cellular Physiology

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The purpose of this study was to investigate the potential mechanism of interleukin‐6 (IL‐6) on the stimulation of excessive androgen secretion in human NCI‐H295R adrenocortical cells. We performed transcriptome sequencing of cancer and paracancerous tissues obtained from functional adrenal cortical adenomas. The secretion of dehydroepiandrosterone sulfate (DHEAS) in NCI‐H295R cells was detected by a chemiluminescence assay. The expression of messenger RNA (mRNA) was detected by real‐time polymerase chain reaction and that of protein was detected by western blotting. The expression of secretogranin II (SCG2) and IL‐6 were significantly increased in cancer tissues. Upregulation of mRNA and protein levels of AKR1C3, CYP11A, CYP17A1, 3βHSD, and SULT2A1 was observed after stimulation with IL‐6. IL‐6 could also increase the expression of StAR mRNA and proteins. Our results suggest that IL‐6 can promote androgen secretion by regulating the expression of genes related to androgen pathways.

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Up-regulation of steroid biosynthesis by retinoid signaling: Implications for aging

Cited by 34 publications

References 85 publications

Consequences of Inadequate Intakes of Vitamin A, Vitamin B12, Vitamin D, Calcium, Iron, and Folate in Older Persons

Consequences of Inadequate Intakes of Vitamin A, Vitamin B12, Vitamin D, Calcium, Iron, and Folate in Older Persons

Melatonin up-regulates the expression of the GATA-4 transcription factor and increases testosterone secretion from Leydig cells through RORα signaling in anin vitrogoat spermatogonial stem cell differentiation culture system

Interleukin‐6 increases adrenal androgen release by regulating the expression of steroidogenic proteins in NCI‐H295R cells

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