Healthcare-associated respiratory tract infection and colonization in an intensive care unit caused by Burkholderia cepacia isolated in mouthwash

Zurita, Jeannete; Mejía, Lorena; Zapata, Sonia; Trueba, Gabriel; Vargas, Ana C. Pinzón; Aguirre, Samanta; Falconí, Guillermo

doi:10.1016/j.ijid.2014.07.016

Cited by 25 publications

(18 citation statements)

References 16 publications

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“…Oropharyngeal bacterial colonization during intubation and poor cough reflex may contribute to the development of pneumonia (Gomes-Filho et al, 2010). The association with mechanical ventilation has been described in previous outbreaks (Guo et al, 2017;Zurita et al, 2014).…”

Section: Discussionmentioning

confidence: 95%

Epidemiological investigation and successful management of a Burkholderia cepacia outbreak in a neurotrauma intensive care unit

Rastogi

Khurana

Veeraraghavan

et al. 2019

International Journal of Infectious Diseases

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Objective: The detailed epidemiological and molecular characterization of an outbreak of Burkholderia cepacia at a neurotrauma intensive care unit of a level 1 trauma centre is described. The stringent infection control interventions taken to successfully curb this outbreak are emphasized. Methods: The clinical and microbiological data for those patients who had more than one blood culture that grew B. cepacia were reviewed. Bacterial identification and antimicrobial susceptibility testing was done using automated Vitek 2 systems. Prospective surveillance, environmental sampling, and multilocus sequence typing (MLST) were performed for extensive source tracking. Intensive infection control measures were taken to further control the hospital spread. Results: Out of a total 48 patients with B. cepacia bacteraemia, 15 (31%) had central line-associated blood stream infections. Two hundred and thirty-one environmental samples were collected and screened, and only two water samples grew B. cepacia with similar phenotypic characteristics. The clinical strains characterized by MLST typing were clonal. However, isolates from the water represented a novel strain type (ST-1289). Intensive terminal cleaning, disinfection of the water supply, and the augmentation of infection control activities were done to curb the outbreak. A subsequent reduction in bacteraemia cases was observed. Conclusion: Early diagnosis and appropriate therapy, along with the rigorous implementation of essential hospital infection control practices is required for successful containment of this pathogen and to curb such an outbreak.

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Section: Discussionmentioning

confidence: 95%

Epidemiological investigation and successful management of a Burkholderia cepacia outbreak in a neurotrauma intensive care unit

Rastogi

Khurana

Veeraraghavan

et al. 2019

International Journal of Infectious Diseases

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“…Burkholderia spp. are known to survive long periods in distilled water [5,6]. This ability to survive in distilled water with minimal additives has made them problematic for healthcare, as hospital-acquired BCC infections can arise from contaminated disinfectants, anesthetic solutions, distilled water, and aqueous chlorhexidine solutions [4].…”

Section: Introductionmentioning

confidence: 99%

Genomic and phenotypic characterization of Burkholderia isolates from the potable water system of the International Space Station

et al. 2020

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“…En Ecuador, las comunicaciones científicas de IAAS son escasas, con sólo tres publicaciones en PubMed [5][6][7] . El objetivo de este manuscrito es comunicar el manejo de un brote intrahospitalario por S. marcescens ocurrido en nuestra UCIN.…”

Section: Introductionunclassified

Brote por Serratia marcescens en una Unidad de Cuidados Intensivos Neonatales: Guayaquil-Ecuador

Soria¹,

Nieto²,

Villacís

et al. 2016

Rev. chil. infectol.

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Serratia marcescens outbreak in Neonatal IntensiveCare Unit. Guayaquil, EcuadorWe report a Serratia marcescens outbreak occurred in the NICU of a pediatric hospital in Guayaquil, Ecuador. Nine cases of infection were detected, from which septicemia was developed in 55.5%. The index case was a newborn derived from another institution with septic arthritis caused by the outbreak strain. The infection rate was 17.6% and mortality rate was 33.3%. All isolates were resistant to aminoglycosides and susceptible to third generation cephalosporins and carbapenems. Clonality analysis by pulsed-field gel electrophoresis (PFGE) revealed the presence of two closely related clones confirming the horizontal spread. Measures were taken by the committee such as: strengthening the hand hygiene, patient hygiene and cohort studies of gastrointestinal colonization, which allowed the control of the outbreak.

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Healthcare-associated respiratory tract infection and colonization in an intensive care unit caused by Burkholderia cepacia isolated in mouthwash

Abstract: Our findings strongly suggest that alcohol-free mouthwash solution intrinsically contaminated with B. cepacia was the source of these colonizations and infections involving adults in the ICU.

Cited by 25 publications

References 16 publications

Epidemiological investigation and successful management of a Burkholderia cepacia outbreak in a neurotrauma intensive care unit

Epidemiological investigation and successful management of a Burkholderia cepacia outbreak in a neurotrauma intensive care unit

Genomic and phenotypic characterization of Burkholderia isolates from the potable water system of the International Space Station

Brote por Serratia marcescens en una Unidad de Cuidados Intensivos Neonatales: Guayaquil-Ecuador

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