Brote por Serratia marcescens en una Unidad de Cuidados Intensivos Neonatales: Guayaquil-Ecuador

Abstract

Serratia marcescens outbreak in Neonatal IntensiveCare Unit. Guayaquil, EcuadorWe report a Serratia marcescens outbreak occurred in the NICU of a pediatric hospital in Guayaquil, Ecuador. Nine cases of infection were detected, from which septicemia was developed in 55.5%. The index case was a newborn derived from another institution with septic arthritis caused by the outbreak strain. The infection rate was 17.6% and mortality rate was 33.3%. All isolates were resistant to aminoglycosides and susceptible to third generation cephalosporins and carbapenems. Clonality analysis by pulsed-field gel electrophoresis (PFGE) revealed the presence of two closely related clones confirming the horizontal spread. Measures were taken by the committee such as: strengthening the hand hygiene, patient hygiene and cohort studies of gastrointestinal colonization, which allowed the control of the outbreak.

Outbreak of Serratia marcescens in the Neonatal Intensive Care Unit of a Tertiary Care Hospital in Mexico

“…In this work, 80% of the cases corresponded to males and 20% to females, which is similar to what has been reported in another outbreak [2], but at the same time, diferent from what has been reported by other researchers [15,24], probably because when the outbreak occurs, it can afect both males and females equally. On the other hand, most of the cases corresponded to neonates born at term with a birth weight of more than 2,500 grams, which contrasts with what has been reported by other authors who identify low birth weight and prematurity as risk factors for morbidity and mortality due to this type of pathogen [19].…”

“…S. marcescens can cause asymptomatic or symptomatic infections with a wide range of clinical manifestations [ 15 ]. Among the symptoms are keratitis, conjunctivitis, urinary tract infections, pneumonia, surgical wound infections, sepsis, meningitis, and bloodstream infections [ 11 , 16 , 17 ].…”

The Hormetic Effect Observed for Benzalkonium Chloride and Didecyldimethylammonium Chloride in Serratia sp. HRI

“…Serratia marcescens is an opportunistic pathogen increasingly associated with infections and outbreaks in neonatal and paediatric healthcare units [ 3 , 4 , 5 , 6 , 7 ]. Healthcare facilities use disinfectant products daily for infection control, wound care, and to prevent the development of antimicrobial resistance.…”

“…Little information exists on the effect of disinfectants on the growth of Serratia species. As a nosocomial pathogen increasingly associated with outbreaks in healthcare facilities [ 3 , 4 , 5 , 6 , 7 ], the impact of sub-lethal levels of disinfectants on the growth of this pathogen is crucial to direct hygiene and safety standards in the future.…”

Resistencia a los antimicrobianos por enterobacterias a nivel de américa latina y el caribe 2013-2023

“…1, pp. 33 -49, enero -marzo 2024 www.anatomiadigital.org pobreza y que los antimicrobianos están disponibles sin necesidad de receta médica en muchos países de la región, da a conocer que la producción y regulación de ventas de estos medicamentos sea inconsistente, lo cual es visible principalmente en el área de salud humana, pero también se recalca en el área agrícola y de veterinaria (2)(3)(4).…”