Health-Related Quality of Life Outcomes in Head and Neck Cancer: Results From a Prospective, Real-World Data Study With Brazilian Patients Treated With Intensity Modulated Radiation Therapy, Conformal and Conventional Radiation Techniques

Santos, Marcos; Silva, Luís Felipe Oliveira e; Köhler, Hugo Fontan; Curioni, Otávio Alberto; Vilela, Ricardo Alencar; Fang, Marcel; Lima, Carmen Sílvia Passos; Gomes, João Pedro Perez; Chaves, Aline Lauda Freitas; Resende, B.C.; Trindade, Karine Martins da; Collares, Mauricio; Obs, Fernando; Brollo, Janaína; Cavalieri, R. Jennifer; Ferreira, Ediane; Brust, Leandro; Rabello, Doralina do Amaral; Domenge, C.; Kowalski, Luiz Paulo

doi:10.1016/j.ijrobp.2020.09.044

Cited by 4 publications

(3 citation statements)

References 42 publications

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“…This study adds to the existing literature on toxicity burden and quality of life after primary radiation therapy. 3,7,[27][28][29][36][37][38][39] Some of the studies mainly aimed to characterize either acute 27 or long-term toxicity burden. 29,37 Other studies aimed to compare the toxicity burden of 3D-CRT with IMRT.…”

Section: Discussionmentioning

confidence: 99%

“…29,37 Other studies aimed to compare the toxicity burden of 3D-CRT with IMRT. 3,7,36,38,39 In addition to these studies, we mapped the complete longitudinal course of multiple prospectively scored symptoms and quality-of-life items of a large cohort, making this one of the most comprehensive reports to date, to our knowledge. Overall, this study's results are consistent with those reported in the existing literature.…”

Section: Discussionmentioning

confidence: 99%

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Patient-Reported Toxicity and Quality-of-Life Profiles in Patients With Head and Neck Cancer Treated With Definitive Radiation Therapy or Chemoradiation

Bosch

Laan

Schaaf

et al. 2021

International Journal of Radiation Oncology*Biology*Physics

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Purpose: Radiation therapy is an effective but burdensome treatment for head and neck cancer (HNC). We aimed to characterize the severity and time pattern of patient-reported symptoms and quality of life in a large cohort of patients with HNC treated with definitive radiation therapy, with or without systemic treatment. Methods and Materials: A total of 859 patients with HNC treated between 2007 and 2017 prospectively completed the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire−Head and Neck Cancer module (QLQ-HN35) and Core Quality of Life Questionnaire (QLQ-C30) at regular intervals during and after treatment for up to 5 years. Patients were classified into 3 subgroups: early larynx cancer, infrahyoideal cancer, and suprahyoideal cancer. Outcome scales of both questionnaires were quantified per subgroup and time point by means of average scores and the frequency distribution of categorized severity (none, mild, moderate, and severe). Time patterns and symptom severity were characterized. Toxicity profiles were compared using linear mixed model analysis. Additional toxicity profiles based on age, human papillomavirus status, treatment modality, smoking status, tumor site, and treatment period were characterized as well. Results: The study population consisted of 157 patients with early larynx cancer, 304 with infrahyoideal cancer, and 398 with suprahyoideal cancer. The overall questionnaire response rate was 83%. Generally, the EORTC QLQ-HN35 symptoms reported showed a clear time pattern, with increasing scores during treatment followed by a gradual recovery in the first

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Patient-Reported Toxicity and Quality-of-Life Profiles in Patients With Head and Neck Cancer Treated With Definitive Radiation Therapy or Chemoradiation

Bosch

Laan

Schaaf

et al. 2021

International Journal of Radiation Oncology*Biology*Physics

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“…In LA, there are vast infrastructural and human resource deficits to meet the RT demands, which underpins the need for access solutions and efficient resource use [ 29 ]. Advances such as intensity-modulated radiotherapy (IMRT) and image-guided radiation therapy (IGRT) have improved outcomes and quality of life [ 30 ]. However, they come with higher costs and demand more quality assurance, qualified personnel, time per patient, and infrastructure investments.…”

Section: Rt Resource Access and Availability In Lamentioning

confidence: 99%

Hypofractionation as a solution to radiotherapy access in latin america: expert perspective

Santos¹,

Chávez-Nogueda²,

Galvis³

et al. 2022

Rep Pract Oncol Radiother.

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Late radiation effects in survivors of head and neck cancer: State of the science

Ortigara

Bonzanini

Schulz

et al. 2021

Critical Reviews in Oncology/Hematology

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Health-Related Quality of Life Outcomes in Head and Neck Cancer: Results From a Prospective, Real-World Data Study With Brazilian Patients Treated With Intensity Modulated Radiation Therapy, Conformal and Conventional Radiation Techniques

Cited by 4 publications

References 42 publications

Patient-Reported Toxicity and Quality-of-Life Profiles in Patients With Head and Neck Cancer Treated With Definitive Radiation Therapy or Chemoradiation

Patient-Reported Toxicity and Quality-of-Life Profiles in Patients With Head and Neck Cancer Treated With Definitive Radiation Therapy or Chemoradiation

Hypofractionation as a solution to radiotherapy access in latin america: expert perspective

Late radiation effects in survivors of head and neck cancer: State of the science

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