Late radiation effects in survivors of head and neck cancer: State of the science

Ortigara, Gabriela Barbieri; Bonzanini, Laura Izabel Lampert; Schulz, Riéli Elis; Ferrazzo, Kívia Linhares

doi:10.1016/j.critrevonc.2021.103335

Cited by 18 publications

(14 citation statements)

References 88 publications

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“…However, these clinical variables showed associations with poor QoL in HNC patients and might have a negative impact on the social functioning of these patients [77]. In accordance with a recent review [78], future studies should investigate QoL using self-report questionnaires specific to HNC population, such as the University of Washington Quality of Life, version 4 (UW-QOL, [79]).…”

Section: Discussionmentioning

confidence: 62%

Psychological variables associated with quality of life in patients with head and neck cancer: the role of body image distress

Cerea

Sansoni

Scarzello

et al. 2022

Support Care Cancer

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Objective The aim of this cross-sectional study was to explore the relationship between quality of life (QoL) and body image distress in patients with head and neck cancer (HNC), considering relevant psychological variables (i.e., coping strategies, social anxiety symptoms, self-esteem, intolerance of uncertainty, pain, and distress). We also aimed to explore gender differences in patients with HNC in terms of relevant psychological variables in HNC. Methods Fifty-one HNC patients (37 males and 14 females) completed self-report questionnaires to assess body image distress, physical and mental QoL, and relevant psychological variables in HNC (coping strategies, social anxiety symptoms, self-esteem, intolerance of uncertainty, pain, and distress) before undergoing treatment. Pearson’s correlations and four-step hierarchical regressions were performed to assess the relationship between body image distress, QoL, and the abovementioned psychological variables, while one-way analyses of variance and one-way analysis of covariance were employed to assess gender differences. Results Physical QoL was associated with body image distress above and beyond disease duration, distress, coping strategies, pain, mental QoL, and self-esteem, while mental QoL was associated with pain above and beyond distress, coping strategies, physical QoL, self-esteem, and body image distress. Concerning gender differences, females scored higher than males on most of the explored psychological variables, except for physical QoL and intolerance of uncertainty, and showed lower mental QoL and self-esteem than males. Conclusion Body image distress and pain emerged as negatively associated with QoL, and almost all the explored psychological variables differed among genders. Psychological interventions targeting body image distress and pain should be promoted in patients with HNC to increase their QoL, while keeping gender differences in mind.

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Section: Discussionmentioning

confidence: 62%

Psychological variables associated with quality of life in patients with head and neck cancer: the role of body image distress

Cerea

Sansoni

Scarzello

et al. 2022

Support Care Cancer

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“…Interestingly, the patients with malignant tumors underwent radiation therapy in the three months following the surgery. The complications associated with adjuvant radiotherapy, including dry mouth, muscle fibrosis, and temporomandibular disorder [ 20 ], could have all had negative effects on masticatory performance [ 21 ]. On the other hand, the patients with benign tumors did not have to undergo this 3-month session of radiotherapy, additionally, the different resection extents between malignant and benign diseases could have also had an effect on the masticatory performance, as more essential muscles were excised in malignant patients.…”

Section: Discussionmentioning

confidence: 99%

Masticatory performance in patients undergoing free fibula flap for mandible reconstruction

et al. 2022

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Background To explore the masticatory performance in patients undergoing an osteo(cutaneous) free fibula (OFF) flap for mandible reconstruction by a prospective design. Methods A total of 56 patients who had undergone OFF flap reconstructions for mandibular reconstruction secondary to malignant (squamous cell carcinoma) or benign (ameloblastoma) tumor resection were prospectively enrolled. They were asked to complete the masticatory performance test by the weigh method and the chew domain of the University of Washington quality of life questionnaire (version 4) preoperatively and at 3, 6, and 12 months postoperatively. The pair nonparametric test was used to analyze the dynamic change of masticatory performance and subjective chew function. Results Fifty-one patients were included for analysis finally. The mean masticatory performance for patients with malignant tumors were 53.4% ± 10.3%, 36.4% ± 10.3%, 42.6% ± 9.6%, 52.8% ± 10.9%, and 53.1% ± 11.8% preoperatively, at 2 weeks, 3 months, 6 months, and 12 months postoperatively, respectively. Compared with the preoperative level, the masticatory performance had a significant reduction immediately after surgery (p < 0.001), followed by a return to the baseline level within three months. A similar trend was noted for those with benign tumors. The mean score of chew domain for patients with malignant tumors were 100 ± 0, 54.3 ± 32.9, 81.4 ± 24.5, and 92.9 ± 17.8 preoperatively, at 3 months, 6 months, and 12 months postoperatively, respectively. Compared with the preoperative level, the subjective chew function was greatly affected within the first three months (p < 0.001), and it gradually recovered to the baseline level in the following nine months. A similar trend was noted in patients with benign tumors. Conclusions The masticatory performance and subjective chew function was significantly affected after OFF flap reconstructions in the short term, but both recovered to the preoperative levels within 9–12 months.

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“…Radiation effects in the oral cavity are also well-established including mucositis, hyposalivation xerostomia, radiation-induced dental caries, trismus, and osteoradionecrosis. 6 Depending on the staging, external beam radiation therapy and brachytherapy have been used successfully as the primary modality for treating patients with early stage oral cancer, and they are the standard of care for use as adjuvant therapy in post-operative cases of patients with advanced stage oral cancer. 7 In our patient, the ominous presentation with oral hemorrhage raised immediate concern for regional recurrence of his malignancy or for a metachronous malignant lesion in his oral cavity.…”

Section: Discussionmentioning

confidence: 99%

Recurrent, oral cavity tumor-like exophytic lesions mimicking neoplastic disease in a patient with history of human papillomavirus-mediated squamous cell carcinoma

Hawthorne

Tham

Ponder

et al. 2021

SAGE Open Medical Case Reports

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Reactive hyperplasia is a phenomenon responsible for exophytic lesions in the oral cavity, and may appear to be suspicious, especially in patients who have a significant history of malignancy. Here, we present a case of reactive hyperplasia mimicking recurrence in a patient who was previously treated for tonsillar carcinoma. Physicians who commonly see patients with oral lesions, particularly oral surgeons and otolaryngologists, should be cognizant of the unusual presentation of these lesions as they may mimic the physical characteristics of recurrence.

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Late radiation effects in survivors of head and neck cancer: State of the science

Cited by 18 publications

References 88 publications

Psychological variables associated with quality of life in patients with head and neck cancer: the role of body image distress

Psychological variables associated with quality of life in patients with head and neck cancer: the role of body image distress

Masticatory performance in patients undergoing free fibula flap for mandible reconstruction

Recurrent, oral cavity tumor-like exophytic lesions mimicking neoplastic disease in a patient with history of human papillomavirus-mediated squamous cell carcinoma

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