Head-to-Head Comparison between High-Resolution Microultrasound Imaging and Multiparametric MRI in Detecting and Local Staging of Bladder Cancer: The BUS-MISS Protocol

Diana, Pietro; Lughezzani, Giovanni; Saita, Alberto; Uleri, Alessandro; Frego, Nicola; Contieri, Roberto; Buffi, N.M.; Balzarini, Luca; D’Orazio, Federico; Colombo, Piergiuseppe; Elefante, Maria Grazia; Lazzeri, Massimo; Guazzoni, Giorgio; Casale, Paolo; Hurle, Rodolfo

doi:10.3233/blc-211611

Cited by 9 publications

(7 citation statements)

References 32 publications

(34 reference statements)

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“…A comparison study of the diagnostic accuracy of mUS vs. MRI in distinguished NMIBC and MIBC at definitive pathological examination. The sensitivity, specificity of mUS and MRI were 85.0% vs. 76.3% and 85.0% vs. 50.0%, respectively [39].…”

Section: Ultrasoundmentioning

confidence: 90%

Advances in Diagnosis and Therapy for Bladder Cancer

2022

Cancers

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Bladder cancer (BCa) is one of the most common and expensive urinary system malignancies for its high recurrence and progression rate. In recent years, immense amounts of studies have been carried out to bring a more comprehensive cognition and numerous promising clinic approaches for BCa therapy. The development of innovative enhanced cystoscopy techniques (optical techniques, imaging systems) and tumor biomarkers-based non-invasive urine screening (DNA methylation-based urine test) would dramatically improve the accuracy of tumor detection, reducing the risk of recurrence and progression of BCa. Moreover, intravesical instillation and systemic therapeutic strategies (cocktail therapy, immunotherapy, vaccine therapy, targeted therapy) also provide plentiful measures to break the predicament of BCa. Several exploratory clinical studies, including novel surgical approaches, pharmaceutical compositions, and bladder preservation techniques, emerged continually, which are supposed to be promising candidates for BCa clinical treatment. Here, recent advances and prospects of diagnosis, intravesical or systemic treatment, and novel drug delivery systems for BCa therapy are reviewed in this paper.

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Section: Ultrasoundmentioning

confidence: 90%

Advances in Diagnosis and Therapy for Bladder Cancer

2022

Cancers

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“…To overcome these drawbacks of mpMRI, several alternative imaging tools have been proposed. One noteworthy imaging tool is the high-resolution microultrasound imaging proposed for BCa detection and staging 32 , which shows an excellent performance compared to that of mpMRI 33 . However, as high-resolution microultrasound imaging is still limited owing to the lack of equipment availability and expertise necessary, a significant learning curve related to the use of high-resolution microultrasound techniques is required 33 .…”

Section: Discussionmentioning

confidence: 99%

“…One noteworthy imaging tool is the high-resolution microultrasound imaging proposed for BCa detection and staging 32 , which shows an excellent performance compared to that of mpMRI 33 . However, as high-resolution microultrasound imaging is still limited owing to the lack of equipment availability and expertise necessary, a significant learning curve related to the use of high-resolution microultrasound techniques is required 33 . Therefore, we focused on bpMRI, a contrast-free protocol based on the standardized reporting system (VI-RADS), and compared the diagnostic performance between bpMRI and mpMRI.…”

Section: Discussionmentioning

confidence: 99%

Comparison between biparametric and multiparametric MRI in predicting muscle invasion by bladder cancer based on the VI-RADS

Noh

Shim

Kang

et al. 2022

Sci Rep

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This study aimed to compare the diagnostic validity of biparametric magnetic resonance imaging (bpMRI) with that of multiparametric MRI (mpMRI) based on the Vesicle Imaging-Reporting and Data System (VI-RADS) in predicting muscle invasion by bladder cancer (BCa). We retrospectively examined 357 patients with an initial diagnosis of BCa who underwent preoperative MRI; 257 and 100 patients underwent mpMRI and bpMRI, respectively. Two urogenital radiologists evaluated all bpMRI and mpMRI scans using VI-RADS, and the diagnostic validity of VI-RADS for predicting muscle invasion by BCa was analyzed based on histopathology of the first and/or second transurethral resection of bladder tumors and radical cystectomy. Receiver operating characteristic (ROC) curves were plotted with the calculation of area under the curves (AUCs), and the level of significance was P < 0.05. Both groups showed optimal performance with a VI-RADS score ≥ 3. BpMRI showed comparable diagnostic performance to mpMRI (reader 1: AUC, 0.903 [0.827–0.954] vs. 0.935 [0.884–0.968], p = 0.510; and reader 2: AUC, 0.901 [0.814–0.945] vs. 0.915 [0.874–0.946]; p = 0.655). The inter-reader agreement between both readers was excellent (Cohen’s kappa value = 0.942 and 0.905 for bpMRI and mpMRI, respectively). This comparative study suggests that bpMRI has comparable diagnostic performance to mpMRI and may be an alternative option to predict muscle invasion by BCa.

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“…The advances in the research of radiological imaging techniques in patients with bladder cancer have made it possible to have more precise and less invasive staging methods, which could lead to better treatment planning with more personalized therapeutic options in selected patients. High-resolution micro-ultrasound (mUS) technology has been introduced very recently and the initial results indicate that mUS may have a better performance than MRI in distinguishing NMIBC from MIBC [ 79 ]. Recently, new hybrid tracers such as indocyanine green (ICG)-99mTc-nanocolloid have been developed, which have also been applied to bladder cancer [ 80 ], although these are very preliminary studies.…”

Section: Discussionmentioning

confidence: 99%

Advances in Transversal Topics Applicable to the Care of Bladder Cancer Patients in the Real-World Setting

Siles

López-Beltrán

Pelechano

et al. 2022

Cancers

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Recommendations regarding transversal topics applicable to bladder cancer patients independent of tumor grade and stage were established by members of the Spanish Oncology Genitourinary Multidisciplinary Working Group (SOGUG). Liquid biopsy in urine and blood samples is useful in the surveillance of non-muscle-invasive and muscle-invasive bladder cancer, respectively. Multiparametric MRI is an accurate, faster and non-invasive staging method overcoming the understaging risk of other procedures. The combination of FDG-PET/MRI could improve diagnostic reliability, but definite criteria for imaging interpretation are still unclear. Hospital oncology pharmacists as members of tumor committees improve the safety of drug use. Additionally, safety recommendations during BCG preparation should be strictly followed. The initial evaluation of patients with bladder cancer should include a multidimensional geriatric assessment. Orthotopic neobladder reconstruction should be offered to motivated patients with full information of self-care requirements. Bladder-sparing protocols, including chemoradiation therapy and immune checkpoints inhibitors (ICIs), should be implemented in centers with well-coordinated multidisciplinary teams and offered to selected patients. The optimal strategy of treatment with ICIs should be defined from the initial diagnostic phase with indications based on scientific evidence. Centralized protocols combined with the experience of professional groups are needed for the integral care of bladder cancer patients.

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Head-to-Head Comparison between High-Resolution Microultrasound Imaging and Multiparametric MRI in Detecting and Local Staging of Bladder Cancer: The BUS-MISS Protocol

Cited by 9 publications

References 32 publications

Advances in Diagnosis and Therapy for Bladder Cancer

Advances in Diagnosis and Therapy for Bladder Cancer

Comparison between biparametric and multiparametric MRI in predicting muscle invasion by bladder cancer based on the VI-RADS

Advances in Transversal Topics Applicable to the Care of Bladder Cancer Patients in the Real-World Setting

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