Comparison between biparametric and multiparametric MRI in predicting muscle invasion by bladder cancer based on the VI-RADS

Noh, Tae Il; Shim, Ji Sung; Kang, Sung Gu; Sung, Deuk Jae; Cheon, Jun; Sim, Ki Choon; Kang, Seok Ho

doi:10.1038/s41598-022-19273-7

Cited by 8 publications

(5 citation statements)

References 43 publications

(67 reference statements)

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“…Additionally, VI‐RADS relies on dynamic contrast‐enhanced MRI, which is not feasible in patients with contraindications to contrast agents. However, emerging research into bi‐parametric MRI assessments of BCa, which do not require contrast and have shorter image acquisition times, indicates comparable efficacy to mpMRI VI‐RADS scoring 56,57 . Further study is needed to validate this approach.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of staging MRI to re‐resection for localised bladder cancer: Narrative review

Klempfner,

Anderson

2024

BJUI Compass

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IntroductionBladder cancer (BCa) is characterised by high prevalence, multifocality, and frequent recurrence, imposing significant clinical and economic burdens. Accurate staging, particularly distinguishing non‐muscle‐invasive bladder cancer (NMIBC) from muscle‐invasive bladder cancer (MIBC) disease, is crucial for guiding treatment decisions. This narrative review explores the potential implications of incorporating multiparametric magnetic resonance imaging (mpMRI) and the Vesical Imaging Reporting Data System (VI‐RADS) into BCa staging, focusing on repeat transurethral resection of bladder tumour (re‐TURBT).MethodsA comprehensive search of PubMed, EMBASE, and MEDLINE databases identified studies published from 2018 to 2023 discussing mpMRI or VI‐RADS in the context of re‐TURBT for BCa staging. Studies meeting inclusion criteria underwent qualitative analysis.ResultsSix recent studies met inclusion criteria. VI‐RADS scoring, accurately predicted muscle invasion, aiding in NMIBC/MIBC differentiation. VI‐RADS scores of ≥3 indicated MIBC with high sensitivity and specificity. VI‐RADS potentially identified patients benefiting from re‐TURBT and those for whom it could be safely omitted.DiscussionmpMRI and VI‐RADS offer promising prospects for BCa staging, potentially correlating more closely with re‐TURBT and radical cystectomy histopathology than initial TURBT. However, validation and careful evaluation of clinical integration are needed. Future research should refine patient selection and optimise mpMRI's role in BCa management.ConclusionVI‐RADS scoring could revolutionise BCa staging, especially regarding re‐TURBT. There is potential that VI‐RADS correlates more with the histopathology of re‐TURBT and radical cystectomy than initial TURBT. While promising, ongoing research is essential to validate utility, refine selection criteria, and address economic considerations. Integration of VI‐RADS into BCa staging holds potential benefits for patients and health care systems.

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Section: Discussionmentioning

confidence: 99%

“…However, emerging research into bi‐parametric MRI assessments of BCa, which do not require contrast and have shorter image acquisition times, indicates comparable efficacy to mpMRI VI‐RADS scoring. 56 , 57 Further study is needed to validate this approach.…”

Section: Discussionmentioning

confidence: 99%

Comparison of staging MRI to re‐resection for localised bladder cancer: Narrative review

Klempfner,

Anderson

2024

BJUI Compass

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“…In cases without DCE-MRI, the final VI-RADS score was based on DWI. This method for assessing VI-RADS in the bi-parametric MRI (bp-MRI) was based on the method of Noh et al [ 4 ].…”

Section: Methodsmentioning

confidence: 99%

Determining the clinicopathological significance of the VI-RADS ≧4 group: a retrospective study

Ikuma,

Akatsuka,

Takeda

et al. 2024

BMC Urol

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Background The Vesical Imaging Reporting and Data System (VI-RADS) is widely used for predicting muscle-invasive bladder cancer (MIBC). This study aimed to determine the clinicopathological significance of the VI-RADS ≧4 (VI≧4) group. Methods Patients who underwent transurethral resections of bladder tumors during the study period and preoperative magnetic resonance imaging were considered. The patients were pathologically diagnosed with urothelial carcinoma (UC). We first compared the results of patients with VI-RADS scores of 3 and 4 to determine the cut-off score for MIBC; thereafter, the patients were divided into the VI≧4 and VI-RADS ≦3 (VI≦3) groups using VI-RADS. The clinicopathological significance of the VI≧4 group was examined retrospectively by comparing the characteristics of each group. Results In total, 121 cases were examined, of which 28 were pathologically diagnosed with MIBC. Of the 28 MIBC cases, three (10.7%) had a VI-RADS score of ≦3, and 25 (89.3%) had a VI-RADS score of ≧4. Of the 93 NMIBC cases, 86 (92.5%) had a VI-RADS score of ≦3, and seven (7.5%) had a VI-RADS score of ≧4. The diagnostic performance of the VI-RADS with a cut-off score of 4 was 89.3% for sensitivity, 92.5% for specificity, and an area under the curve (AUC) of 0.91. Contrastingly, for a cut-off score of 3, the sensitivity was 89.3%, specificity was 62.0%, and AUC was 0.72. A VI-RADS score of ≥ 4 could predict MIBC. In the VI≧4 group, 30 of 32 (93.8%) patients had high-grade tumors. The VI≧4 group had significantly more high-grade bladder cancers than the VI≦3 group (p < 0.001 OR = 31.77 95%CI:8.47–1119.07). In addition, the VI≧4 group had more tumor necrosis (VI≧4 vs VI≦3, p < 0.001 OR = 7.46 95%CI:2.61–21.34) and more UC variant cases (VI≧4 vs VI≦3, p = 0.034 OR = 3.28 95%CI:1.05–10.25) than the VI≦3 group. Conclusions This study suggests that VI-RADS has a high diagnostic performance in predicting MIBC and that VI-RADS could diagnose high-grade tumors, necrosis, and UC variants.

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“…The authors[ 3 ] retrospectively analyzed the preoperative magnetic resonance imaging (MRI) of 357 patients with BCa (multiparametric MRI-(mpMRI) in 257 and biparametric MRI-(bpMRI) in 100). Using Vesicle Imaging Reporting and Data System (VIRADS), two radiologists assessed all the scans.…”

Section: Comparison Between Biparametric and Multiparametric Magnetic...mentioning

confidence: 99%

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Mandal

2023

Indian J Urol

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Comparison between biparametric and multiparametric MRI in predicting muscle invasion by bladder cancer based on the VI-RADS

Cited by 8 publications

References 43 publications

Comparison of staging MRI to re‐resection for localised bladder cancer: Narrative review

Comparison of staging MRI to re‐resection for localised bladder cancer: Narrative review

Determining the clinicopathological significance of the VI-RADS ≧4 group: a retrospective study

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