HE4 is an independent prognostic marker in endometrial cancer patients

Mutz-Dehbalaie, Irene; Egle, Daniel; Fessler, Siegfried; Hubalek, Michael; Fiegl, Heidi; Marth, Christian; Widschwendter, Andreas

doi:10.1016/j.ygyno.2012.04.022

Cited by 80 publications

(74 citation statements)

References 25 publications

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“…Kalogera et al [32], using a cutoff value of 8 mfi, showed that the specificity for detecting patients with myometrial invasion less than 50% and stage I disease was 75% and 76%, respectively. MutzDehbalaie et al [33] decided to use the value of 81 pmol/l to individualize patients with deep myometrial invasion. According to international guidelines, lymphadenectomy must be performed in the presence of deep myometrial invasion, as there is an increased risk of lymph node metastasis.…”

Section: Discussionmentioning

confidence: 99%

Utility of HE4 to identify patients with endometrioid endometrial cancer who may require lymphadenectomy

Dobrzycka

Maćkowiak-Matejczyk²,

Terlikowska

et al. 2016

Advances in Medical Sciences

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Section: Discussionmentioning

confidence: 99%

Utility of HE4 to identify patients with endometrioid endometrial cancer who may require lymphadenectomy

Dobrzycka

Maćkowiak-Matejczyk²,

Terlikowska

et al. 2016

Advances in Medical Sciences

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“…However, the literature includes some controversial findings regarding the studies on the prognostic significance of CA 125 as a tumor marker to evaluate the prevalence and therapeutic response of the disease. While some of the reports indicate that the increased preoperative CA 125 levels are an independent prognostic factor for malign surveys, some others indicated the lack of correlation between CA 125 levels and prevalence of the disease [23]. In the multi-centered study of Kim et al [24] which included 413 patients and in which they looked into the significance of preoperative CA 125 for endometrial cancer, they indicated it will not contribute to the selection of high preoperative risk patients or will not ensure additional contributions to the selection of intermediate to high risk patients who may need adjuvant radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

Endometrial and Ovarian Cancer with MR Imaging Importance of Serum HE4 and CA 125 Levels in the Extent of Disease at Evaluation

Yılmaz

Kumtepe

2017

Eurasian J Med

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Objective: Currently, no clinically useful tumor marker is available for primary diagnosis in endometrial cancer. Human epididymis protein-4 (HE-4) has high sensitivity and specificity as a tumor marker. Further, HE-4 has been shown to be elevated in early stage endometrial cancer and is more sensitive than CA 125. In our study, CA 125 and HE-4 reputation as a tumor marker for diagnosis of ovarian and endometrial cancer with the use of both the availability and affect the way we investigated the rate of diagnosis. Materials and Methods:Here 20 patients with ovarian cancer, 26 patients with endometrial cancer, which had been histologically diagnosed, and 40 healthy volunteers were included. Peripheral blood samples were taken and serum CA 125 and HE-4 were tested.Results: Serum CA 125 and HE-4 levels in patients with ovarian cancer were found to be significantly higher than those in healthy volunteers (p<0.05). Receiver-operating characteristic (ROC) analysis was performed. For patients with ovarian cancer and healthy controls, the CA 125 (0.83) and HE-4 (0.84) levels showed increased sensitivity (95%). There was no significant difference in the CA 125 levels in patients with endometrial cancer and healthy controls (p>0.05), whereas HE-4 levels were found to be higher in patients with endometrial cancer than in healthy controls (p<0.05). ROC analysis was performed. For endometrial cancer patients and healthy controls, the CA 125 (0.59) and HE-4 (0.63) levels showed increased sensitivity (88.5%). Conclusion:In ovarian and endometrial cancer, wherein early diagnosis is the most important factor for prognosis and survival, HE-4 is a new serum tumor marker that can be used with the aim of noninvasive diagnoses. For early diagnosis, the concomitant use of CA 125 and HE-4 is more effective and reliable than using either of them alone.Keywords: Ovary, endometrium, cancer, diagnosis, tumor marker ÖZ Amaç: CA 125 erken evre over kanserlerinin sadece %50'sinde yükselir. Endometrium kanserinde klinik pratikte rutin olarak kullanılan tümör marker yoktur. Human epididimis protein-4 (HE-4) over kanserlerinde yüksek sensitivite ve spesifiteye sahiptir. Endometrial kanserde CA 125 den daha sensitif olduğu ve erken evrede yükseldiği gösterilmiştir. Çalışmamızda CA 125 ve HE-4'ün over ve endometrium kanserinde tümör markerı olarak kullanılabilirliğini ve ikisinin birlikte kullanımın teşhis oranını ne şekilde etkileyeceğini araştırdık.Gereç ve Yöntem: Çalışmamıza histopatolojik olarak tanısı konulan 20 over kanseri, 26 endometrium kanseri hasta ile jinekolojik problemi olmayan 40 sağlıklı gönüllü dahil edilmiştir. MR görüntülemesiyle FIGO sistemine göre evreleri belirlendi. Hastalardan preoperatif olarak ve sağlıklı gönüllülerden periferik kan alınarak serum CA 125 ve HE-4 düzeyleri çalışıldı.Bulgular: Over kanseri hastalarının serum CA 125 ve HE-4 düzeyleri sağlıklı kontrollerinkinden anlamlı yüksek bulundu (p<0,05). ROC (Receiver Operatör Characteristic) analizi uygulandığında over kanseri hastalarında CA 125 (0,83) ve HE...

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“…We are, therefore, developing further specific mAbs to increase the specificity. Recently serum human epididymis protein 4 (HE4) has been used for the detection of endometrial cancer [23][24][25][26][27]. Angioli et al reported that the sensitivity and specificity of serum HE4 test were 59% and 100%, respectively [27].…”

Section: Discussionmentioning

confidence: 99%

Usefulness of Immuno-Magnetic Beads Conjugated with Anti-EpCAM Antibody for Detecting Endometrial Cancer Cells

Koga¹,

Katayose²,

Onoda³

et al. 2013

JCT

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A simple and non-invasive method for detecting endometrial cancer in women with abnormal uterine bleeding is required. For this purpose, we prepared immuno-magnetic beads conjugated with anti-human EpCAM rat monoclonal antibody (mAb) for isolating exfoliated endometrial cells including endometrial cancer cells in vaginal discharge. The affinities of the anti-human EpCAM rat mAbs were analyzed by flow cytometry and immunocytochemistry and then magnetic beads were conjugated with the mAbs. The rate of retrieval of endometrial cells using the immuno-magnetic beads was calculated. Endometrial cells were isolated using the immuno-magnetic beads from the vaginal discharges of 22 patients with endometrial cancer and 16 non-malignant controls. The isolated cells were stained using endometrial cancer specific-mAbs and analyzed by flow cytometry and imaging cytometry. The immuno-magnetic beads conjugated with high-affinity mAb (clone 1456) appeared to have very low auto-fluorescence. Sufficient enrichment of Ep-CAMpositive cells using immuno-magnetic beads was observed in both simulation and clinical samples. The overall sensitivities of flow cytometry and imaging cytometry to detect endometrial cancer cells were 72.7% and 45.5%, respectively. Meanwhile, the overall specificities of flow cytometry and imaging cytometry for healthy controls were 75.0% and 81.3%, respectively. Our immuno-magnetic beads have very low auto-fluorescence, so they could be useful for fluorescent analysis, such as fluorescent immunochemical staining. In the future, these novel immuno-magnetic beads could be used for cytological study.

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HE4 is an independent prognostic marker in endometrial cancer patients

Cited by 80 publications

References 25 publications

Utility of HE4 to identify patients with endometrioid endometrial cancer who may require lymphadenectomy

Utility of HE4 to identify patients with endometrioid endometrial cancer who may require lymphadenectomy

Endometrial and Ovarian Cancer with MR Imaging Importance of Serum HE4 and CA 125 Levels in the Extent of Disease at Evaluation

Usefulness of Immuno-Magnetic Beads Conjugated with Anti-EpCAM Antibody for Detecting Endometrial Cancer Cells

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