HCV infection and chronic arthritis: Does viral replication matter?

Tarantino, Giovanni; Riccio, Antonio; Spanò, Angelo; Loi, G.; Padula, Stefania; Ladogana, Paolo; Postiglione, Loredana; Scarpa, Raffaele

doi:10.1016/j.hepres.2006.03.013

Cited by 8 publications

(7 citation statements)

References 18 publications

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“…It is noteworthy to stress out that HCV titers were lower in serum of patients with RF than in patients without RF. Interestingly, previous reports have shown a negative correlation between viral titers and detection of either RF or ANA in subgroups of HCV infected patients with increased markers of hepatic damage (25,27). However, in our work, ANA was not related to viral load and similar levels of biochemical markers of liver damage were observed between samples with or without RF and ANA.…”

Section: Discussioncontrasting

confidence: 60%

High prevalence of a variety of autoantibodies in a population of hepatitis C virus‐infected individuals

Navarta

Espul

Acosta‐Rivero

2018

APMIS

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Hepatitis C virus (HCV) infection has been related to self-reactivity, extrahepatic manifestations and autoimmune diseases. The main goals of this work were to study the prevalence of autoantibodies and their relationship with viral titers and biochemical markers of hepatic damage in patients infected with HCV. Autoantibodies (ANA, AMA, SMA, APC, LKM, DNAds, ANCA, ATG and RF) were determined in 73 individuals with chronic HCV infection and 44 healthy volunteers. The presence of these antibodies was related to demographic variables, viral titers and biochemical parameters. A high prevalence of autoantibodies, particularly for RF, that was associated with female gender was observed in HCV-infected patients. In addition, SMA, ANA and ATG showed increased frequencies in HCV infection. Interestingly, the concurrent detection of SMA and more than one autoantibody was associated with high gGT levels. Notably, concurrent higher gGT, HCV and SMA levels were observed in male patients as compared to their female counterparts. These results indicate a relationship between HCV infection and the concurrent detection of various autoantibodies in the absence of symptoms of autoimmune diseases. They also suggest a link among the presence of a variety of autoantibodies simultaneously with SMA, increased gGT levels and HCV titers in a population of male patients.

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Section: Discussioncontrasting

confidence: 60%

High prevalence of a variety of autoantibodies in a population of hepatitis C virus‐infected individuals

Navarta

Espul

Acosta‐Rivero

2018

APMIS

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“…These data suggest that in a significant percentage of cases the presence of arthritis during the course of HCV infection is not related to the viral replication, confirming published data (9). In previous studies (10), hepatic damage was reported to be independent ofviral replication during the course ofHCV infection, suggesting that host immune response is more important in the pathogenesis of chronic hepatitis, rather than the direct viropathic effect.…”

Section: Department Of Clinical and Experimental Medicine Of The Fedesupporting

confidence: 88%

Lack of HCV Replication during the Course of HCV-Associated Arthritis

et al. 2008

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Viral replication was evaluated by PCR in the serum of 25 subjects with lICV-associated arthritis. Active replication resulted in 16 cases, only 10 of which presenting hypertransaminasemia. A significant correlation appeared between serum Rheumatoid Factor concentrations and viral replication only in 7 patients with hypertransaminasemia. These data suggest that the onset of arthritis in this infection is due to an autoimmune mechanism, not linked to the HCV replication.

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“…This difference could be explained since viral agents can stimulate IL-6 production, and an IL-6 of viral origin, directly linking to gp130, has been recently recognized (25). Also viraemia appeared unrelated to IL-6, sIL-6r and gp130 serum levels, and this confirms that the autoimmune process triggering HCVrA is independent from viral replication (23). This is the first study demonstrating similar behaviour of serum IL-6 and its receptors in the two diseases.…”

Section: Discussionmentioning

confidence: 67%

“…Distinction between HCVrA and classical RA is often difficult (17), because HCVrA patients fulfilling the current classification criteria for RA are often observed, and anti-CCPa, although considered serological markers specific for RA by many Authors, were found in more than 30% of the HCVrA cases (22). The onset of arthritis in the course of HCV infection seems related to autoimmune virus-induced changes rather than to a direct action of HCV (23): the presence of autoimmunity is suggested also by the high prevalence (about 70%) ofRF positivity in course ofHCV infection (24).…”

Section: Discussionmentioning

confidence: 99%

Similar Serum Levels of IL-6 and its Soluble Receptors in Patients with HCV-Related Arthritis and Rheumatoid Arthritis: A Pilot Study

Riccio

Postiglione²,

Sabatini

et al. 2012

Int J Immunopathol Pharmacol

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The high serum levels of Interleukin-6 (IL-6) and its soluble receptors (sIL-6r and sgp 130), described in the course of Rheumatoid Arthritis (RA), have been linked to the enhanced activity of this cytokine in this disorder. In this study, the serum concentrations of IL-6 and its soluble receptors were determined in a group of patients with HCV-related arthritis (HCVrA), a condition resembling RA in several aspects, and then compared to those found in a sample of subjects affected by RA. Twenty-one patients with HCVrA, 24 patients with RA and 20 healthy subjects (control group) were examined. Different ELISA methods were used for determination of serum concentrations of IL-6, sIL-6r and sgp 130. Increased IL-6 serum levels were found in 15 (71%) of the patients with HCVrA and in 16 (62%) of those with RA. Eight (38%) of the patients with HCVrA and 11 (46%) of those with RA denoted high levels of sIL-6r, while sgp 130 levels were elevated in 21 (76%) of the patients with HCVrA and in 16 (69%) of those with RA. A significant difference between the median values of sIL-6r and sgp 130 levels in the two groups of patients versus controls was found. A mild correlation of these parameters with RF levels was detected in the RA group. Furthermore, in HCVrA patients the serum levels of IL-6, sIL-6r and sgpl30 appeared unrelated to HCV viraemia and to levels of transaminases. The enhanced serum levels of IL-6 in HCVra patients indicate an increased synthesis and hyperactivity of this cytokine in HCVrA, and the substantial similarity of the behaviour of IL-6 and its serum receptors in the two groups of patients suggests common mechanisms with RA, in which the function of IL-6 is central.

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HCV infection and chronic arthritis: Does viral replication matter?

Cited by 8 publications

References 18 publications

High prevalence of a variety of autoantibodies in a population of hepatitis C virus‐infected individuals

High prevalence of a variety of autoantibodies in a population of hepatitis C virus‐infected individuals

Lack of HCV Replication during the Course of HCV-Associated Arthritis

Similar Serum Levels of IL-6 and its Soluble Receptors in Patients with HCV-Related Arthritis and Rheumatoid Arthritis: A Pilot Study

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