Lack of HCV Replication during the Course of HCV-Associated Arthritis

Riccio, Antonio; Postiglione, Loredana; Spanò, Angelo; Tarantino, Giovanni

doi:10.1177/1721727x0800600307

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…For example, the question of a connection between vaccination and autism is surrounded by controversy. In addition, several studies showing elevated brain-specific antibodies in autism support an autoimmune mechanism (22)(23)(24)(25). However, recently it has been reported that vaccines, as well as autoimmunity do not seem to be the cause of autism.…”

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confidence: 99%

Autism and Immunity: Revisited Study

Castellani

Conti

Kempuraj

et al. 2009

Int J Immunopathol Pharmacol

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Autism spectrum disorder is of interest neurochemically because it represents a relatively homogeneous disorder with regard to disease development, abnormal cognitive development and intellectual development disturbance. A consistent finding in autistic children is a high number of mast cells and a high level of serotonin which is also found at elevated concentrations in the urine of autistic patients. In addition, a dysfunction of clinical conditions, such as gastrointestinal and immunological symptoms, is frequently noted in autistic children, however, IgE does not appear to be prevalent in these children but probably an increase of cytokines/chemokines produced by mast cells at an early age may play an important role. Therefore an immune hypothesis, involving also autoimmunity, is one possible pathogenetic mechanism in autism. In conclusion, mast cell activation could contribute to immune and neuroinflammatory abnormalities that are evident in patients with autism spectrum disorders.Autism and autism spectrum disorders are complex neuro-developmental disorders characterized by disturbance and impairments in social skills and interaction, verbal communication,

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confidence: 99%

Autism and Immunity: Revisited Study

Castellani

Conti

Kempuraj

et al. 2009

Int J Immunopathol Pharmacol

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“…Mast cell producing cytokines/chemokines can substantially enhance T cell recruitment to local infection demonstrating that they are not only important in IgE-associatcd disorders, but also contribute to the host defence against bacteria (36)(37)(38)(39)(40)(41). Mast cells have diverse potential contribution during innate and acquired immunity and in other biological responses (42)(43)(44)(45). These findings suggest that mast cells may have a much more versatile role than previously suspected.…”

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confidence: 90%

Impact of IL-32 on Histamine Release by Human Derived Umbilical Cord Blood Mast Cells

et al. 2009

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IL-32 is onae of the last important cytokines discovered, produced mainly by T cells, natural killer cells, and epithelial cells. Probably many other different cells are a source oflL-32, which has been found to be a powerful pro-inflammatory mediator. Here we studied the effect of IL-32 on histamine release by human-derived cord-blood mast cells. In these studies we found that IL-32 significantly stimulates the release of histamine only at high concentrations (100 ng/ml) while at 10 or 50 ng/ml it had no effect. These results were found for the first time and demonstrate that IL-32 may play an important role in allergic and inflammatory diseases.

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Lack of HCV Replication during the Course of HCV-Associated Arthritis

Cited by 2 publications

References 6 publications

Autism and Immunity: Revisited Study

Autism and Immunity: Revisited Study

Impact of IL-32 on Histamine Release by Human Derived Umbilical Cord Blood Mast Cells

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