HBC-nanofiber hydrogel scaffolds with 3D printed internal microchannels for enhanced cartilage differentiation

Liu, Xiaoyun; Song, Shousen; Huang, Jie; Fu, Han; Ning, Xinyu; He, Yong; Zhang, Zhijun

doi:10.1039/d0tb00616e

Cited by 47 publications

(27 citation statements)

References 50 publications

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“…The nanofiber loaded hydrogels showed the presence of key components of the cartilage matrix, that is, glycosaminoglycans (GAG) and collagen II, indicating the differentiation of hMSCs. However, the hydrogel lacks sufficient mechanical strength of native cartilage, and hence PCL was used to provide the framework of a 3D volumetric complex 128 …”

Section: Electrospun Nanofiber Reinforced Composites For the Delivery Of Small Molecules Genes And Proteins In Multiple Ailmentsmentioning

confidence: 99%

Reinforced electrospun nanofiber composites for drug delivery applications

Anup

Chavan

et al. 2021

J Biomedical Materials Res

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Electrospun technology becomes a valuable means of fabricating functional polymeric nanofibers with distinctive morphological properties for drug delivery applications. Nanofibers are prepared from the polymer solution, which allows the direct incorporation of therapeutics such as small drug molecules, genes, and proteins by merely mixing them into the polymeric solution. Due to their biocompatibility, adhesiveness, sterility, and efficiency in delivering diverse cargoes, electrospun nanofibers have gained much attention. This review discusses the capabilities of the electrospun nanofibers in delivering different therapeutics like small molecules, genes, and proteins to their desired target site for treating various ailments. The potential of nanofibers in administering through multiple administration routes and the associated challenges has also been expounded along with a cross‐talk about the commercial products of nanofibers for biomedical applications.

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Section: Electrospun Nanofiber Reinforced Composites For the Delivery Of Small Molecules Genes And Proteins In Multiple Ailmentsmentioning

confidence: 99%

Reinforced electrospun nanofiber composites for drug delivery applications

Anup

Chavan

et al. 2021

J Biomedical Materials Res

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“…The study outcome suggested that the developed scaffold system exhibited excellent proliferation and differentiation of the cells which indicates their performance in cartilage tissue engineering [135]. A recent study reported by Liu and co-workers have demonstrated the fabrication of poly(ε-caprolactone) (PCL) framework reinforced with poly(lactic-co-glycolic acid) (PLGA) electrospun nanofiber incorporated hydroxybutyl chitosan (HBC) hydrogels [136]. Briefly, PLGA nanofibers have been prepared through electrospinning and fragmented through an aminolysis degradation reaction.…”

Section: Cartilage Tissue Engineeringmentioning

confidence: 99%

“…Figure 11 clearly indicates the preparation process and differentiation of the human mesenchymal stem cells (hMSCs) in vitro and cartilage regeneration in vivo. Especially, the in vivo study demonstrated significant induction of cartilage differentiation of the hMSCs [136]. Therefore, it is well evidenced that efforts have been continuously made on the fabrication of scaffolds by adopting different strategies and materials with various architecture in order to achieve enhanced cartilage regeneration.…”

Section: Cartilage Tissue Engineeringmentioning

confidence: 99%

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Electrospun Nanofibers for Wound Dressing and Tissue Engineering Applications

Balusamy

Anitha

Uyar

2020

Hacettepe Journal of Biology and Chemistry

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E lektro-eğirme yöntemi ile üretilen nanolifler, son yıllarda nanofibröz yapı iskelelerinin geliştirilmesinde büyük ilgi gördü ve biyomimetik yapıları nedeniyle farklı biyomedikal uygulamalarda kullanıldı. Özellikle, elektro-eğirme yöntemi ile üretilen nanolifler doğal hücre dışı matris (ECM), birbirine bağlı gözenekler, geniş yüzey alanı, işlevselleştirme kolaylığı ve hücre adezyonunu, farklılaşmasını ve proliferasyon davranışını etkilemede büyük önem taşıyan mekanik performans dahil olmak üzere birçok faydalı özellik sergiler. Bugüne kadar, çok çeşitli yararlı özellikleri kabul eden bu nanolifler, yara örtüsü ve doku mühendisliği uygulamalarında kullanılmıştır. Bu derlemede, çeşitli malzemelerin ve yaklaşımların kullanımını gösteren birkaç temsili örneklerle bu alanlarda çeşitli çabaların yapıldığını özetlemektedir. Ayrıca, klinik faz transferine ilişkin gelecekteki yön endişeleri tartışılmıştır. Anahtar Kelimeler Elektro-eğirme, nanolif, yara örtüsü, doku mühendisliği.

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“…For repair or regeneration purposes, biomedical scaffolds are often indicated as an advantageous solution as they can provide a 3D framework to enable cell proliferation, matrix deposition, and consequent tissue regeneration [11]. From work published in this area, the most common natural materials used in such devices are collagen, agarose, chitosan, hyaluronic acid, fibrin, and alginate [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

3D Printing for Cartilage Replacement: A Preliminary Study to Explore New Polymers

2022

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The use of additive manufacturing technologies for biomedical applications must begin with the knowledge of the material to be used, by envisaging a very specific application rather than a more general aim. In this work, the preliminary study was focused on considering the cartilaginous tissue. This biological tissue exhibits different characteristics, such as thickness and mechanical properties, depending on its specific function in the body. Due to the lack of vascularization, cartilage is a supporting connective tissue with limited capacity for recovery and regeneration. For this reason, any approach, whether to repair/regenerate or as a total replacement, needs to fulfill the adequate mechanical and chemical properties of the surrounding native cartilage to be successful. This work aims to explore the possibility of using new polymers for cartilage total replacement approaches with polymeric materials processed with the specific 3D printing technique of fused filament fabrication (FFF). The materials studied were Nylon® 12 (PA12), already described for this purpose, and LAY-FOMM® 60 (FOMM). FOMM has not been described in the literature for biomedical purposes. Therefore, the chemical, thermal, swelling capacity, and mechanical properties of the filaments were thoroughly characterized to better understand the structure–properties–application relationships of this new polymer. In addition, as the FFF technology is temperature based, the properties were also evaluated in the printed specimens. Due to the envisaged application, the specimens were also characterized in the wet state. When comparing the obtained results with the properties of native cartilage, it was possible to conclude that: (i) PA12 exhibits low swelling capacity, while FOMM, in its dry and wet forms, has a higher swelling capacity, closer to that of native cartilage; (ii) the mechanical properties of the polymeric materials, especially PA12, are higher than those of native cartilage; and (iii) from the mechanical properties evaluated by ultra-micro hardness tests, the values for FOMM indicate that this material could be a good alternative for cartilage replacement in older patients. This preliminary study, essentially devoted to expanding the frontiers of the current state of the art of new polymeric materials, provides valuable indications for future work targeting the envisaged applications.

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HBC-nanofiber hydrogel scaffolds with 3D printed internal microchannels for enhanced cartilage differentiation

Abstract: HBC-nanofiber hydrogel scaffolds with 3D printed internal microchannels have been developed to provide a multifunctional biomimetic microenvironment for hMSC chondrogenesis.

Cited by 47 publications

References 50 publications

Reinforced electrospun nanofiber composites for drug delivery applications

Reinforced electrospun nanofiber composites for drug delivery applications

Electrospun Nanofibers for Wound Dressing and Tissue Engineering Applications

3D Printing for Cartilage Replacement: A Preliminary Study to Explore New Polymers

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