HbA1C and its Correlation with Lipid Profile in Acute Myocardial Infarction

Bhattacharjee, Prithwiraj; Das, Polok; Nath, Bhaskar Kanti; Basumatary, Atanu; Das, Dwijen

doi:10.21276/ijcmr.2018.5.4.6

Cited by 7 publications

(6 citation statements)

References 6 publications

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“…A closer examination revealed that LDL-C levels had a negative correlation only with triglycerides and had positive correlations with SBP, HbA1C, HDL-C levels, and triglycerides in females. This was supported by a study conducted by Bhattacharjee et al [ 30 ] that reported that LDL-C levels was significantly correlated with HbA1C in a positive direction among myocardial infarction patients. A study among diabetes patients in Iran found that LDL-C levels was significantly positively correlated with both DBP and SBP [ 31 ].…”

Section: Discussionsupporting

confidence: 67%

Factors associated with elevated low-density lipoprotein cholesterol levels among hill tribe people aged 30 years and over in Thailand: a cross-sectional study

et al. 2021

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Background Low-density lipoprotein cholesterol (LDL-C) is one of the most important types of cholesterol and has an impact on health. Certain lifestyle and dietary habits in different populations may leads to increased levels of LDL-C, particularly among those with poor education and economic statuses, such as hill tribe people in Thailand. This study aimed to estimate the prevalence of and determine the factors associated with high LDL-C levels among hill tribe people in northern Thailand. Methods A cross-sectional study was performed to gather information from six main hill tribe populations: Akha, Lahu, Hmong, Yao, Karen, and Lisu. Individuals who were aged over 30 years and living in 30 selected hill tribe villages were invited to participate in the study. A validated questionnaire and 5-mL blood specimens were used to obtain data. Correlation analyses, chi-square tests, t-tests, and logistic regression were used to detect correlations and associations. Results A total of 2552 participants were recruited into the study; 65.9% were females, and 64.1% were aged younger than 60 years old. Approximately 69.6% of participants had abnormal LDL-C levels; 33.6% had above-optimal levels, 24.3% had borderline high levels, 8.0% had high levels, and 3.7% had very high levels. A total of 17.4% of participants had low high-density lipoprotein cholesterol (HDL-C) and high LDL-C levels, while 14.9% had high triglyceride and LDL-C levels. After controlling for sex, age, religion, education, annual family income, and marital status in the multivariate model, three variables were found to be associated with high LDL-C levels: occupation, the amount of lard used in daily cooking, and glycated hemoglobin (HbA1c). Those who were working as agriculturalists had a 1.34-fold greater chance of having abnormal LDL-C than traders and others (95% CI = 1.09–1.34). Those who used moderate and high quantities of lard in their daily cooking had a 1.45-fold (95% CI = 1.15–1.82) and 1.31-fold (95% CI = 1.04–1.68) greater likelihood of having abnormal LDL-C levels than those who used low quantities, respectively. Those who had abnormal HbA1c levels were less likely to develop abnormal LDL-C levels than those who had normal HbA1c levels (AOR = 0.69, 95% CI = 0.51–92). Conclusions Effective public health programs that do not conflict with the cultures of hill tribes are urgently needed, particularly programs encouraging the use of small quantities of lard for daily cooking practices.

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Section: Discussionsupporting

confidence: 67%

Factors associated with elevated low-density lipoprotein cholesterol levels among hill tribe people aged 30 years and over in Thailand: a cross-sectional study

et al. 2021

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“…Their correlation between HbA1c and HDL-C was negative and was statistically non-significant. A study in India reported similar findings of direct significant correlation between HbA1c and TC, TG, LDL-C, TC/HDL-C, LDL-C/HDL-C and there was inverse correlation between HbA1c and HDL [ 29 ], while another study reported that HbA1c levels had a significant direct relationship with TC, TG and LDL-C but not with HDL-C [ 35 ].…”

Section: Discussionmentioning

confidence: 86%

“…This prevalence was consistent with findings of Bhattacharjee et al . who found poor glycaemic control in 60% of their patients [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…Also, Bhattacharjee et al . reported that patients with HbA1c ≥ 7% had a significant increase in TC, LDL-C, TG, TC/HDL-C and LDL-C/HDL-C ratio and a decrease in their HDL-C levels as compared to patients with HbA1c < 7.0% [ 29 ]. It is important to target better glycaemic control, because improving glycaemic control may substantially reduce the risk of cardiovascular events.…”

Section: Discussionmentioning

confidence: 99%

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Relationship between glycaemic control and lipid profile in type 2 diabetes mellitus patients in a low-resource setting

Nnakenyi¹,

Nnakenyi²,

Parker³

et al. 2022

Pan Afr Med J

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Introduction diabetes mellitus can lead to complications including cardiovascular disease (CVD). Glycated haemoglobin (HbA1C) is a test of glycaemic control in T2DM patients, and its association with CVD can be mediated through modulation of risk factors such as dyslipidaemia. It is suggested that correlation of HbA1c with blood lipids may enable its use as a dual marker for glycaemic status and dyslipidaemia. The aim of this study was to determine the relationship between glycaemic control and blood lipid concentrations in T2DM patients. Methods a cross-sectional study of T2DM patients at Enugu, Nigeria. After obtaining informed consent, questionnaires were administered, and then venous blood was collected for determination of HbA1c and fasting lipid profile. Student T-test was used to compare mean results of two groups and Pearson correlation coefficient was used to determine relationships. A p-value <0.05 was considered to be statistically significant. Results fifty -five (55) T2DM patients comprising of 24 females and 31 males, with mean±SD age 57±12 years were studied. Prevalence of patients with poor glycaemic control (HbA1c≥7%) was 34 (61.8%). More males (36.4%) than females (25.4%) had poor glycaemic control. There was a positive, statistically significant correlation between HbA1c and TC (r=0.406); Low-Density Lipoprotein Cholesterol (LDL-C) (r=0.409); and triglyceride (TG) (r=0.273), p<0.05. Correlation between HbA1c and HDL-C was negative (r=-0.269, p<0.05). Conclusion the significant correlation between HbA1c and various lipid parameters may suggest the importance of glycaemic control as well as managing dyslipidaemia in the reduction of risk for CVD in T2DM patients, for which HbA1c may be used to monitor both, thereby reducing cost.

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“…26 A study from north eastern Indian population investigated the lipid profile and its correlation with HbA1c levels in incidence of myocardial infarction, which concluded that 60% patients with myocardial infarction had poor glycaemic control and found that the serum HbA1c level has direct relationship with the serum lipid profile and is indirectly associated with levels of HDL cholesterol. 27 A study conducted by Anand et al established that serum HbA1c levels, adequate glycaemic control, and lipid profile screening help to identify high-risk patients for timely diagnosis of hyperlipidaemia, hence decreases the incidence of cardiovascular diseases and peripheral vascular complications through appropriate interventions. 28 Mahajan et al conducted a study, which showed positive correlation of HbA1c with LDL, triglycerides, total cholesterol, high-density lipoprotein, very-low-density lipoprotein, and low-density lipoprotein C levels.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Dyslipidemia with HbA1c levels in Diabetes Mellitus

Malathi¹,

Fatima

Ahmed³

2022

IJCBR

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Diabetes is a metabolic disease which has hyperglycaemia resulting from defects in insulin secretion or action. HbA1C is one of the most reliable test used for estimation of glycaemic index. Diabetes is often accompanied by undiagnosed dyslipidaemia, characterized by increased triglyceride level, decreased high-density lipoprotein levels and increase in low-density lipoprotein (LDL) particles. Diabetes is a significant risk factor for atherosclerotic cardiovascular disease (ASCVD). The purpose of this study was to correlate lipid parameters with different levels of HbA1c to assess dyslipidaemia with diabetic status. An observational study was conducted in biochemistry laboratory at Gandhi Hospital, Telangana.After informed consent, 5ml of venous blood sample was collected in plain tube and EDTA tube from diabetic and apparently non diabetic patients. Estimation of serum triglycerides was done by glycerol phosphate oxidase peroxidase, serum cholesterol by cholesterol oxidase method, serum HDL by direct clearance method in Beckmann Coulter AU 500 and HbA1c was estimated by high performance liquid chromatography in Bio-Rad D10.A total of 90 samples were divided into 3 groups according to their HbA1c results. Group 1 with HbA1c less than 5.6, Group 2 with HbA1c 5.6-7 and Group 3 with HbA1c more than 7.The present study showed no variation in the lipid profile in Group1 with HbA1c < 5.6. In Group 2 with HbA1c between 5.6-7, there was significant increase in LDL cholesterol. In Group 3 with HbA1c >7 there was marked increase in LDL, serum triglyceride. Hence we can conclude that dyslipidemia is increased in poor glycemic control and evaluation of HbA1c may also be used as a predictor of dyslipidaemia in diabetics.

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HbA1C and its Correlation with Lipid Profile in Acute Myocardial Infarction

Cited by 7 publications

References 6 publications

Factors associated with elevated low-density lipoprotein cholesterol levels among hill tribe people aged 30 years and over in Thailand: a cross-sectional study

Factors associated with elevated low-density lipoprotein cholesterol levels among hill tribe people aged 30 years and over in Thailand: a cross-sectional study

Relationship between glycaemic control and lipid profile in type 2 diabetes mellitus patients in a low-resource setting

Evaluation of Dyslipidemia with HbA1c levels in Diabetes Mellitus

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