“…Therefore, we thought that light chain imbalances in a relative small number of cells, which are not supported by heavy chain rearrangements, may occur in HT and should not be considered indicative of HT. This occurrence had already been described in HT [4,5,6], although the corresponding percentages were quite variable [4,5,6], depending also on the different technical procedures [4,5,6]. Conversely, in 2 of our TL FNC-FC cases [3], FC showed light chain restrictions in almost all the gated B-lymphocytes in 1 case and, paradoxically, light chain restrictions were not expressed in the other case in which the cytological features suggested high-grade non-Hodgkin lymphoma.…”