Hashimoto's Thyroiditis in Children and Adolescents: A Retrospective Study on Clinical, Epidemiological and Laboratory Properties of the Disease

Demirbilek, Hüseyin; Kandemir, Nurgün; Gönç, E. Nazlı; Özön, Alev; Alikaşifoğlu, Ayfer; Yordam, Nurşen

doi:10.1515/jpem.2007.20.11.1199

Cited by 79 publications

(87 citation statements)

References 21 publications

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“…In a study from iodine-replete area, twenty-four patients (21%) were euthyroid, 48 (42%) had compensated hypothyroidism, and 42 (37%) had hypothyroidism (including two patients with transient hyperthyroidism reversed to hypothyroidism within weeks). There was no difference in clinical symptoms of hypothyroidism by thyroid status, except for a higher rate of constipation in the hypothyroid group (38). The fact that many children with lymphocytic thyroiditis do not have elevated levels of TSH indicates that the goiter may be caused by the lymphocytic infiltrations or by thyroid growth-stimulating immunoglobulins.…”

Section: Laboratory Findingsmentioning

confidence: 84%

“…Upon admission, 18.6% of patients had complaints related to hypothyroidism (7.4% growth retardation, 4.9% weight gain and 6.3% other complaints related to hypothyroidism). Eighteen patients (11.1%) were diagnosed incidentally upon detection of goiter during routine examination (38). Staii et al reviewed 761 patients for which ultrasound guided thyroid fine needle aspiration biopsy were performed for nodule.…”

Section: Clinical Manifestationmentioning

confidence: 99%

See 1 more Smart Citation

Hashimoto's Thyroiditis in Children and Adolescents

Sarı¹,

Karaoğlu²,

Yeşilkaya³

2011

Autoimmune Disorders - Current Concepts and Advances From Bedside to Mechanistic Insights

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Section: Laboratory Findingsmentioning

confidence: 84%

Section: Clinical Manifestationmentioning

confidence: 99%

Hashimoto's Thyroiditis in Children and Adolescents

Sarı¹,

Karaoğlu²,

Yeşilkaya³

2011

Autoimmune Disorders - Current Concepts and Advances From Bedside to Mechanistic Insights

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“…In this study we detected an association with family history somewhat higher than Demirbilek et al, who found that 40% of patients had a family history of thyroid disease. 12 The evolutionary study detected a trend towards an improved clinical course among patients diagnosed due to an accidental finding and a worse clinical course among those who showed clinical manifestations of thyroid disease. Fava et al 2 found a similar association.…”

Section: Discussionmentioning

confidence: 97%

Hashimoto’s disease in a cohort of 29 children and adolescents. Epidemiology, clinical course, and comorbidities in the short and long term

López

Nso-Roca

Ruíz

et al. 2018

Arch Argent Pediatr

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Hashimoto's thyroiditis is the most common cause of goiter and hypothyroidism among children and adolescents. Its clinical manifestations and course vary. The objective of this study was to review the clinical and evolutionary characteristics of Hashimoto's disease in the pediatric population. Clinical, analytical, ultrasound, epidemiological, and evolutionary data of patients with autoimmune thyroiditis seen at Hospital Universitario San Juan de Alicante between January 2010 and January 2016 were analyzed. A total of 29 patients were included in the study. A higher prevalence of girls was observed, at a 2:1 ratio. The main reason for consultation was the accidental detection of high thyroid stimulating hormone levels or positive anti-thyroid antibodies in a lab test done for other reason. In the initial analysis, 53.3% of patients had subclinical hypothyroidism and only 10% of them had frank hypothyroidism. Two patients developed thyroid cancer. INTRODUCTIONHashimoto's thyroiditis is the most common cause of thyroid disease among children and adolescents. [1][2][3] The histological characteristics of this disease include the presence of a diffuse lymphocytic infiltrate in the thyroid gland accompanied by a variable degree of fibrosis.Its clinical manifestations at the time of diagnosis and clinical course vary. Most patients have no symptoms and a normal thyroid function at the time of diagnosis. Among symptomatic patients, the most common clinical manifestations are goiter and growth retardation. This disease is characterized by the presence of anti-thyroid peroxidase (TPO) antibodies and anti-thyroglobulin (TG) antibodies in blood. A thyroid hormone analysis and ultrasound are useful to make a complete diagnosis of these patients.The objective of this study was to review the clinical and evolutionary characteristics of Hashimoto's disease in a pediatric population. POPULATION AND METHODSHospital Universitario San Juan de Alicante sees patients from the Department of Health 17 of the Valencian Community and caters for a population of 220 000 inhabitants, with over 33 000 children and adolescents younger than 15 years.A descriptive, retrospective study was done in a cohort of patients diagnosed with autoimmune thyroiditis before 18 years old and seen at the Department of Pediatrics of Hospital Universitario San Juan de Alicante between January 2010 and January 2016.The study was approved by the hospital's Ethics Committee.The medical records of patients with final diagnosis of Hashimoto's thyroiditis or disease, autoimmune thyroiditis or hypothyroidism or chronic lymphocytic thyroiditis were included. presence of anti-thyroid antibodies; their followup included a complete physical examination and a thyroid function test every 6 months and labs, including complete autoimmunity testing, every year. An ultrasound was done initially and then twice-yearly. Different clinical, analytical, and ultrasound outcome measures were analyzed. The most important outcome measures included year and age at the time of d...

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“…Hemos detectado una asociación familiar algo superior a Demirbilek et al, que hallaron un 40% de pacientes con antecedentes familiares en su estudio. 12 En el estudio evolutivo, se detectó una tendencia a mejor evolución en los pacientes que habían sido diagnosticados por un hallazgo analítico casual y una peor en los que aparecieron con clínica tiroidea. Fava et al 2 encontraron una asociación semejante.…”

Section: Discussionunclassified

Enfermedad de Hashimoto en una cohorte de 29 niños y adolescentes. Epidemiología, evolución y comorbilidad a corto y largo plazo

2018

Arch Argent Pediatr

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RESUMENLa tiroiditis de Hashimoto es la causa más común de bocio e hipotiroidismo en niños y adolescentes. Las manifestaciones clínicas y la evolución son variables. El objetivo de este trabajo es revisar las particularidades clínicas y evolutivas de la enfermedad de Hashimoto en población pediátrica. Se analizaron datos clínicos, analíticos, ecográficos, epidemiológicos y evolutivos de los pacientes con tiroiditis autoinmune del Hospital Universitario San Juan de Alicante desde enero de 2010 hasta enero de 2016. En el estudio, se incluyeron un total de 29 pacientes. Se observó una mayor prevalencia en niñas con una relación 2:1. El principal motivo de consulta fue la detección casual de una hormona estimulante de la tiroides elevada o de positividad de anticuerpos antitiroideos en una analítica por otro motivo. En la analítica inicial, el 53,3% de los pacientes presentaba hipotiroidismo subclínico y tan solo el 10% de ellos, hipotiroidismo franco. Dos de los pacientes desarrollaron cáncer de tiroides. Palabras clave: enfermedad de Hashimoto, tiroiditis autoinmune, hipotiroidismo, niño.

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Hashimoto's Thyroiditis in Children and Adolescents: A Retrospective Study on Clinical, Epidemiological and Laboratory Properties of the Disease

Abstract: Autoimmune thyroiditis is more frequent in females, and increases in frequency over age during childhood and adolescence. At the time of diagnosis, frequency of overt and subclinical hypothyroidism is similar to that of euthyroid goiter.

Cited by 79 publications

References 21 publications

Hashimoto's Thyroiditis in Children and Adolescents

Hashimoto's Thyroiditis in Children and Adolescents

Hashimoto’s disease in a cohort of 29 children and adolescents. Epidemiology, clinical course, and comorbidities in the short and long term

Enfermedad de Hashimoto en una cohorte de 29 niños y adolescentes. Epidemiología, evolución y comorbilidad a corto y largo plazo

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