Hashimoto's Thyroiditis in Children and Adolescents

Sarı, Erkan; Karaoğlu, Abdülbaki; Yeşilkaya, Ediz

doi:10.5772/24755

Cited by 5 publications

(7 citation statements)

References 79 publications

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“…Thyroid hormone plays crucial role in development and differentiation of the central nervous system, physical growth and pubertal development, dental and skeletal growth, metabolism, and functional maintenance of organs 6) . Congenital hypothyroidism is classified as the most common endocrine disorder in childhood showing the deficiency of thyroid hormone from the birth with an incidence of 1/4,000 newborns according to the screening test of Fisher 1) .…”

Section: Discussionmentioning

confidence: 99%

Changes of antithroglobulin antibody in children with congenital hypothyroidism

Cho

Kim

Choi

et al. 2013

Ann Pediatr Endocrinol Metab

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PurposeIt has been reported that antithroglobulin (anti-TG) antibody is increased in the sera of both children with transient congenital hypothyroidism and their mothers. And transplacental transport of thyroid autoantibody was proposed as the pathogenesis of transient congenital hypothyroidism. However this is not known in nontransient congenital hypothyroidism. This study was done to see changes of anti-TG antibody in children with nontransient congenital hypothyroidism.MethodsStudy patients consisted of 60 patients diagnosed as congenital hypothyroidism in the Department of Pediatrics, Kyungpook National University Children's Hospital, Daegu, Republic of Korea between January 2010 and March 2013. Healthy control were 45 children showing normal thyroid function. Anti-TG antibody and various laboratory tests were analyzed retrospectively, and compared in both children with congenital hypothyroidism and controls.ResultsAnti-TG antibody was significantly higher in children with congenital hypothyroidism compared to healthy controls, 119.4±34.7 U/mL versus 80.6±19.6 U/mL, respectively (P<0.001). There was no significant difference of anti-TG antibody in gender and age.ConclusionWe observed a significant increase of anti-TG antibody in children with nontransient congenital hypothyroidism compared to healthy controls. Further study focusing pathogenetic role of anti-TG antibody in nontransient congenital hypothyroidism is necessary. Furthermore, the clinical significance in the course of congenital hypothyroidism need to be known.

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Section: Discussionmentioning

confidence: 99%

Changes of antithroglobulin antibody in children with congenital hypothyroidism

Cho

Kim

Choi

et al. 2013

Ann Pediatr Endocrinol Metab

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“…Hashimoto's disease is characterised by an autoimmune thyroiditis that is the most common cause of thyroid disease in children, with prevalence rates of up to 3% in some populations (Sari 2011). This disorder has a genetic basis and may be triggered by infection.…”

Section: Hashimoto's Diseasementioning

confidence: 99%

“…The insidious onset of hypothyroidism, with symptoms that may be suggestive of hyperthyroidism (such as excessive sweating, nervousness, irritability and over-activity) can lead to delayed diagnosis, particularly as goitre is not necessarily present. More rarely, psychotic symptoms associated with gradual cognitive decline can point to the development of Hashimoto’s encephalopathy, which is a rare condition with a diagnosis confirmed by the presence of elevated thyroid autoantibodies (Sari 2011). In Down syndrome a clinical diagnosis of thyroid disorder may be difficult, but there is a high prevalence of Hashimoto’s disease, with a risk that reversible cognitive decline and behavioural disturbance may be missed or even misdiagnosed as an Alzheimer-type presentation (which is recognised as a risk in young adults with Down syndrome).…”

Section: Common Autoimmune Medical Conditionsmentioning

confidence: 99%

Autoimmune disorders in child psychiatry: keeping up with the field

Warrilow¹,

Morton²

2015

BJPsych advances

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SummaryAutoimmune disorders in children and adolescents can have significant neuropsychiatric complications and there is growing interest in the association between autoimmune conditions and psychiatric syndromes, particularly in Down syndrome. Acute presentations with psychiatric symptoms require careful assessment in order to recognise and plan treatment of underlying autoimmune disease in collaboration with paediatric colleagues. Difficult treatment decisions arise in children with established autoimmune diagnoses and psychiatric symptoms that may be a result of neuroimmunological processes associated with their condition, psychiatric side-effects of drug treatments or psychopathology resulting from other factors in the history that may or may not have a direct relation to the autoimmune diagnosis. This article illustrates these complexities through discussion of specific autoimmune disorders and three case histories.

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“…HT is primarily a disease of adult and senior women between 45-65 years. When compared to men it has 10 to 20 times more female sex predilection [4,5]. HT in children rarely occurs before four years of age with a peak age of incidence around adolescence (10-12 years) [3].…”

Section: Introductionmentioning

confidence: 99%

Autoimmune thyroid diseases and genetic factors

Guliyeva¹,

Guliyeva²,

Abiyev³

et al. 2022

World J. Adv. Res. Rev.

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The autoimmune thyroid condition with the highest prevalence is Hashimoto's thyroiditis (HT). Autoimmune thyroid diseases (AITD), including Graves’ disease (GD) and Hashimoto’s thyroiditis, arise due to complex interactions between environmental and genetic factors. Each is presenting with distinct clinical features. Significant progress has been made in our understanding of the mechanisms leading to AITD. Because of the complex nature of AITD, caused by their polygenic nature and a complex mode of inheritance, there are still more questions to be answered than answers that can be given, especially about the nature of Hashimoto’s thyroiditis. One of the cornerstones to understanding illness pathophysiology and creating better treatments is figuring out the genetic component of AITD. Common HT and GD genes have been identified, as well as genes that are characteristic of only one of those diseases.

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Hashimoto's Thyroiditis in Children and Adolescents

Cited by 5 publications

References 79 publications

Changes of antithroglobulin antibody in children with congenital hypothyroidism

Changes of antithroglobulin antibody in children with congenital hypothyroidism

Autoimmune disorders in child psychiatry: keeping up with the field

Autoimmune thyroid diseases and genetic factors

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