Hardystonite improves biocompatibility and strength of electrospun polycaprolactone nanofibers over hydroxyapatite: A comparative study

Jaiswal, Akhilesh; Chhabra, Hemlata; Kashte, Shivaji; Londhe, Kishore; Soni, Vivek; Bellare, Jayesh

doi:10.1016/j.msec.2013.03.020

Cited by 59 publications

(40 citation statements)

References 68 publications

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“…However, an increase in fiber diameter was observed (from nanometer to submicron size). The result was in contrast with another study where the fiber diameter was observed to be decreased after adding nHA into PCL (Croisier et al 2012;Jaiswal et al 2013). However, they used another solvent to produce electrospun HA/PCL nanofibers and it is well known in literature that the solvent plays an important role in fiber diameter sizes (Table 3.3).…”

Section: Fabrication Of Electrospun Hydroxyapatite/ Polycaprolactone contrasting

confidence: 99%

Composite Synthetic Scaffolds for Tissue Engineering and Regenerative Medicine

Sultana¹,

Hassan²,

Lim³

2015

SpringerBriefs in Materials

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Section: Fabrication Of Electrospun Hydroxyapatite/ Polycaprolactone contrasting

confidence: 99%

Composite Synthetic Scaffolds for Tissue Engineering and Regenerative Medicine

Sultana¹,

Hassan²,

Lim³

2015

SpringerBriefs in Materials

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“…Nevertheless, scaffolds loaded with 75 wt % akermanite particles showed the best biological activity when tested using human adipose-derived stem cells (hASCs), which enhanced cell viability and osteogenic gene expression (osteocalcin and alkaline phosphatase (ALP)) while reducing interleukin (IL)-6 expression. Hardystonite and hydroxyapatite powders were mixed with PCL to produce composite nanofibres by electrospinning (Figure 8) [122]. PCL-hardystonite nanofibres containing 40 wt % hardystonite particles showed increase in tensile strength (~10 MPa) compared to the PCL control (~6 MPa).…”

Section: Development Of Dcscs For Broader Clinical Applicationsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Doped Calcium Silicate Ceramics: A New Class of Candidates for Synthetic Bone Substitutes

Zreiqat

2017

Materials

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Doped calcium silicate ceramics (DCSCs) have recently gained immense interest as a new class of candidates for the treatment of bone defects. Although calcium phosphates and bioactive glasses have remained the mainstream of ceramic bone substitutes, their clinical use is limited by suboptimal mechanical properties. DCSCs are a class of calcium silicate ceramics which are developed through the ionic substitution of calcium ions, the incorporation of metal oxides into the base binary xCaO–ySiO2 system, or a combination of both. Due to their unique compositions and ability to release bioactive ions, DCSCs exhibit enhanced mechanical and biological properties. Such characteristics offer significant advantages over existing ceramic bone substitutes, and underline the future potential of adopting DCSCs for clinical use in bone reconstruction to produce improved outcomes. This review will discuss the effects of different dopant elements and oxides on the characteristics of DCSCs for applications in bone repair, including mechanical properties, degradation and ion release characteristics, radiopacity, and biological activity (in vitro and in vivo). Recent advances in the development of DCSCs for broader clinical applications will also be discussed, including DCSC composites, coated DCSC scaffolds and DCSC-coated metal implants.

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“…Electrospinning of nHA/PCL using acetone solvent is not frequently reported and utilized. Common solvents that have been used to dissolve PCL for fabricating PCL nanofiber are dichloromethane/dimethyl formamide (Wutticharoenmongkol et al 2006), trifluoroethanol (Samavedi et al 2011), methanol/chloroform (Zhang et al 2007), methylene chloride/dimethyl formamide (Li et al 2012), and hexafluoroethanol (Jaiswal et al 2013). Some of these solvents are harmful and required attentive caution and safety precautions while preparing the solution for electrospinning.…”

Section: Introductionmentioning

confidence: 99%

Characterization, drug loading and antibacterial activity of nanohydroxyapatite/polycaprolactone (nHA/PCL) electrospun membrane

Hassan

Sultana

2017

3 Biotech

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Considering the important factor of bioactive nanohydoxyapatite (nHA) to enhance osteoconductivity or bone-bonding capacity, nHA was incorporated into an electrospun polycaprolactone (PCL) membrane using electrospinning techniques. The viscosity of the PCL and nHA/PCL with different concentrations of nHA was measured and the morphology of the electrospun membranes was compared using a field emission scanning electron microscopy. The water contact angle of the nanofiber determined the wettability of the membranes of different concentrations. The surface roughness of the electrospun nanofibers fabricated from pure PCL and nHA/PCL was determined and compared using atomic force microscopy. Attenuated total reflectance Fourier transform infrared spectroscopy was used to study the chemical bonding of the composite electrospun nanofibers. Beadless nanofibers were achieved after the incorporation of nHA with a diameter of 200-700 nm. Results showed that the fiber diameter and the surface roughness of electrospun nanofibers were significantly increased after the incorporation of nHA. In contrast, the water contact angle (132°± 3.5°) was reduced for PCL membrane after addition of 10% (w/ w) nHA (112°± 3.0°). Ultimate tensile strengths of PCL membrane and 10% (w/w) nHA/PCL membrane were 25.02 ± 2.3 and 18.5 ± 4.4 MPa. A model drug tetracycline hydrochloride was successfully loaded in the membrane and the membrane demonstrated good antibacterial effects against the growth of bacteria by showing inhibition zone for E. coli (2.53 ± 0.06 cm) and B. cereus (2.87 ± 0.06 cm).

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Hardystonite improves biocompatibility and strength of electrospun polycaprolactone nanofibers over hydroxyapatite: A comparative study

Cited by 59 publications

References 68 publications

Composite Synthetic Scaffolds for Tissue Engineering and Regenerative Medicine

Composite Synthetic Scaffolds for Tissue Engineering and Regenerative Medicine

Doped Calcium Silicate Ceramics: A New Class of Candidates for Synthetic Bone Substitutes

Characterization, drug loading and antibacterial activity of nanohydroxyapatite/polycaprolactone (nHA/PCL) electrospun membrane

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