Doped Calcium Silicate Ceramics: A New Class of Candidates for Synthetic Bone Substitutes

No, Young Jung; Li, Jiao Jiao; Zreiqat, Hala

doi:10.3390/ma10020153

Cited by 87 publications

(63 citation statements)

References 154 publications

(252 reference statements)

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“…In the present work, we have developed a new fast‐setting calcium silicate cement doped with Zn and Mg that can be used in different biomedical applications, specifically in dentistry. DCSs are considered a new class of materials that are being used in orthopedics in the form of presintered ceramics as scaffold materials, bone defects filling materials, and implant coatings, but they have not yet been applied in different endodontic (root canal treatment) applications. The preparation of these DCSs involves ion substitution of calcium with divalent ions, as well as the incorporation of some metal oxides into x CaO‐ y SiO 2 system containing divalent ions such as Zn, Mg, Sr, Ti, and Zr .…”

Section: Discussionmentioning

confidence: 99%

“…DCSs are considered a new class of materials that are being used in orthopedics in the form of presintered ceramics as scaffold materials, bone defects filling materials, and implant coatings, but they have not yet been applied in different endodontic (root canal treatment) applications. The preparation of these DCSs involves ion substitution of calcium with divalent ions, as well as the incorporation of some metal oxides into x CaO‐ y SiO 2 system containing divalent ions such as Zn, Mg, Sr, Ti, and Zr . The principle behind using these particular metal oxides for doping is that they contain the same metallic elements as the trace elements found in bone, which could improve the biological response to calcium silicate ceramics as well as their physicochemical properties.…”

Section: Discussionmentioning

confidence: 99%

“…The preparation of these DCSs involves ion substitution of calcium with divalent ions, as well as the incorporation of some metal oxides into x CaOy SiO 2 system containing divalent ions such as Zn, Mg, Sr, Ti, and Zr. 20 The principle behind using these particular metal oxides for doping is that they contain the same metallic elements as the trace elements found in bone, which could improve the biological response to calcium silicate ceramics as well as their physicochemical properties. We have investigated two different concentrations of Zn, because the concentration of Zn is a crucial factor and plays an important role in cellular response and bioactivity of the material.…”

Section: Discussionmentioning

confidence: 99%

“…Ion incorporated calcium silicate ceramics are a new category of materials, which have unique several properties that overcome the disadvantages of calcium silicate ceramics and favored their use in different biomedical applications Zn is an important trace element involved in multiple metabolic functions and important to normal bone growth.…”

Section: Introductionmentioning

confidence: 99%

“…Ion incorporated calcium silicate ceramics are a new category of materials, which have unique several properties that overcome the disadvantages of calcium silicate ceramics and favored their use in different biomedical applications. 20 The incorporation of inorganic elements such as divalent zinc and magnesium cations into calcium silicate ceramics has been shown to enhance their chemical stability, handling properties, bioactivity, biological performance, and antimicrobial activity, 21,22 Zn is an important trace element involved in multiple metabolic functions and important to normal bone growth. Its incorporation into biomaterials can stimulate osteoblasts differentiation through upregulating the expression of bone marker genes.…”

Section: Introductionmentioning

confidence: 99%

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A novel, doped calcium silicate bioceramic synthesized by sol–gel method: Investigation of setting time and biological properties

et al. 2019

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The aim of the current study was to synthesize a fast‐setting ion‐doped calcium silicate bioceramic by the sol–gel method and to characterize its in vitro apatite‐forming ability and cell viability. Calcium silicate (CS), doped calcium silicate with zinc and magnesium, with Ca/Zn molar ratios of 6.7:1 (DCS1), and 4.5:1 (DCS2), were synthesized by the sol–gel method. Matreva white MTA (WMTA, Matreva, CA, Egypt) was used as a control. The synthesized powders were characterized by x‐ray diffraction. Setting time was measured using the Gilmore needle indentation technique. The in vitro apatite‐forming ability of the materials was evaluated by scanning electron microscope and energy dispersive X‐ray. NIH3T3‐E1 cells viability was tested using MTT assay. The ion release of Ca, Si, Zn, and Mg was measured using inductive coupled plasma‐optical emission spectroscopy (ICP‐OES). One‐way ANOVA was used to analyze setting time results. The Tukey's HSD post hoc test was used to establish significance (p < 0.001). For nonparametric data, the Kruskal–Wallis H test with Dunn's correction for post hoc comparison was used (p < 0.05). CS, DCS1, and DCS2 showed a significant decrease in setting time 33 ± 1.63 min, 28 ± 1.63 min, and 41.75 ± 2.87 min, respectively, compared to WMTA 91 ± 3.16 min (p < 0.001). DCS1 showed the highest apatite‐forming ability and cell viability compared to the other groups. Ca and Si ions release decreased in both DCS1 and DCS2. The physical and biological properties of CS can be successfully improved by the sol–gel synthesis and ions doping. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 108B:56–66, 2020.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Ion incorporated calcium silicate ceramics are a new category of materials, which have unique several properties that overcome the disadvantages of calcium silicate ceramics and favored their use in different biomedical applications Zn is an important trace element involved in multiple metabolic functions and important to normal bone growth.…”

Section: Introductionmentioning

confidence: 99%

“…Ion incorporated calcium silicate ceramics are a new category of materials, which have unique several properties that overcome the disadvantages of calcium silicate ceramics and favored their use in different biomedical applications. 20 The incorporation of inorganic elements such as divalent zinc and magnesium cations into calcium silicate ceramics has been shown to enhance their chemical stability, handling properties, bioactivity, biological performance, and antimicrobial activity, 21,22 Zn is an important trace element involved in multiple metabolic functions and important to normal bone growth. Its incorporation into biomaterials can stimulate osteoblasts differentiation through upregulating the expression of bone marker genes.…”

Section: Introductionmentioning

confidence: 99%

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A novel, doped calcium silicate bioceramic synthesized by sol–gel method: Investigation of setting time and biological properties

et al. 2019

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How Does Scaffold Porosity Conduct Bone Tissue Regeneration?

et al. 2021

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Despite progresses in tissue healing, repairing large bone defects remains an unmet challenge. Tissue engineering (TE) using porous scaffolds offers great promise in providing solutions by which bone healing can be increased, and the need for further surgical intervention can be reduced. Nonetheless, the successful performance of a porous scaffold depends on key structural factors including porosity, pore size, geometry, and interconnectivity. Herein, recent advancements on this topic are reviewed and the effects of fabrication methods on making potential scaffolds for advanced bone regeneration are discussed.The upward trend of population aging, increased numbers of accidents, sport injuries, trauma, and bone tumor resection are increasing the demand for substitutes to regenerate and/or repair damaged skeletal and dental bones. [1] Bone tissue poses a simple yet highly organized ultracomposition in which each portion plays a pivotal role in moderating the elasticity and strength of the bone. [2] The intrinsically dynamic bone tissue structure allows the restoration of damaged parts via the self-healing process. [3] This remodeling process is dependent on the dynamic equilibrium between the bone-forming (osteoblast) and bone-resorbing cells (osteoclast) during mechanical stimulation. [4] Nevertheless, this healing process is not sufficient for repairing massive and critical bone defects; thus, there is a need for drastic healing accelerators and substitutive or supportive therapeutics. [5] Specially, the regenerating of large bone defects is a serious and challenging clinical issue. To address the issue, different types of bone graft substitutes such as autografts, allografts, and xenografts are used. [6] These grafts, however, come with certain drawbacks, including donor site morbidity and limited supply. Moreover, aged persons cannot provide rich bone tissue for their own tissue replacement due to osteoporosis. [7] To address the limitations associated with natural bone-derived substitutes, biomaterials have been developed during recent decades. [8] Engineering biomaterials made it possible to simulate the bone microenvironment and construct programmable scaffolds for purposeful therapeutic procedures. Bioactive ceramic materials are favorable for bone tissue engineering (BTE) due to their resemblance to the mineral phase of bone, and direct bonding with host bone tissue without the formation of fibrous tissue. In addition, the variety in the chemical composition of bioceramics, particularly silicate-based ceramics (SiCa), can contribute to adjustments in mechanical properties, bioactivity, and biodegradability.A fundamental constituent of engineering tissue is the scaffold, which acts as the structural template providing a suitable substrate for cell proliferation, differentiation, and attachment resulting in new tissue formation. In tissue engineering (TE), the scaffold serves as the structural guide and the substrate for cell anchorage. The scaffold also contributes to the remodeling of the extracellular mat...

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Current Approaches to Bone Tissue Engineering: The Interface between Biology and Engineering

Ebied

et al. 2017

Adv Healthcare Materials

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121

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The successful regeneration of bone tissue to replace areas of bone loss in large defects or at load-bearing sites remains a significant clinical challenge. Over the past few decades, major progress is achieved in the field of bone tissue engineering to provide alternative therapies, particularly through approaches that are at the interface of biology and engineering. To satisfy the diverse regenerative requirements of bone tissue, the field moves toward highly integrated approaches incorporating the knowledge and techniques from multiple disciplines, and typically involves the use of biomaterials as an essential element for supporting or inducing bone regeneration. This review summarizes the types of approaches currently used in bone tissue engineering, beginning with those primarily based on biology or engineering, and moving into integrated approaches in the areas of biomaterial developments, biomimetic design, and scalable methods for treating large or load-bearing bone defects, while highlighting potential areas for collaboration and providing an outlook on future developments.

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Doped Calcium Silicate Ceramics: A New Class of Candidates for Synthetic Bone Substitutes

Cited by 87 publications

References 154 publications

A novel, doped calcium silicate bioceramic synthesized by sol–gel method: Investigation of setting time and biological properties

A novel, doped calcium silicate bioceramic synthesized by sol–gel method: Investigation of setting time and biological properties

How Does Scaffold Porosity Conduct Bone Tissue Regeneration?

Current Approaches to Bone Tissue Engineering: The Interface between Biology and Engineering

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