Haptoglobin2-2 phenotype is an additional risk factor of retinopathy in type 2 diabetes mellitus

Mogarekar, Mukund Ramchandra; Hampe, Mahesh H

doi:10.4103/0971-6866.116111

Cited by 8 publications

(4 citation statements)

References 23 publications

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“…In addition to cardiovascular risk and complications, Hp genotype also correlates to increased risk for diabetic retinopathy in people with type 2 diabetes. In patients with normal blood pressure, Mogarekar and Hampe ( 137 ) showed an increased risk for the development of severe retinopathy in those with the Hp2-2 genotype. When compared to other genotypes, this study showed a graded risk relationship with the number of Hp2 alleles.…”

Section: Disease Implications Of Hp Polymorphismmentioning

confidence: 97%

Role of Haptoglobin in Health and Disease: A Focus on Diabetes

MacKellar¹,

Vigerust

2016

Clinical Diabetes

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In Brief Prospective identification of individuals with diabetes who are at greatest risk for developing complications would have considerable public health importance by allowing appropriate resources to be focused on those who would benefit most from aggressive intervention. Haptoglobin (Hp) is an acute-phase protein that is crucial for the elimination of free hemoglobin and the neutralization of oxidative damage. In the past two decades, associations have been made between polymorphisms in Hp and complications arising from diabetes. Individuals with polymorphism in Hp have been shown to have significantly higher risk of developing cardiovascular disease. This review summarizes the current literature on the role of Hp in health and disease, with a focus on diabetes.

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Section: Disease Implications Of Hp Polymorphismmentioning

confidence: 97%

Role of Haptoglobin in Health and Disease: A Focus on Diabetes

MacKellar¹,

Vigerust

2016

Clinical Diabetes

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“…In this study, two studies [ 13 , 14 ] in the recessive model, allele model, and additive model all showed no heterogeneity of the studies between DR and DWR ( X 2 p = 0.08, I 2 = 68%; X 2 p = 0.11, I 2 = 60%; and X 2 p = 0.07, I 2 = 68%, resp. ); the subtotal effect size OR in this study was 2.23 (95% CI: 0.68, 7.35), 1.74 (95% CI: 0.72, 4.18), and 2.21 (95% CI: 0.66, 7.44), respectively, all suggesting that Hp gene variants were not associated with NPDR ( Figure 8 ).…”

Section: Resultsmentioning

confidence: 49%

“…The literature search yielded 295 references, six articles [ 13 – 18 ] out of which were eligible for inclusion finally. Figure 1 outlines the study selection.…”

Section: Resultsmentioning

confidence: 99%

The Association of Haptoglobin Gene Variants and Retinopathy in Type 2 Diabetic Patients: A Meta-Analysis

Shi

Yuan

et al. 2017

Journal of Diabetes Research

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Aims/Introduction To collectively evaluate the association between haptoglobin (Hp) gene variants and diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM). Methods A comprehensive literature review was performed for eligible studies. After inclusion and exclusion selection as well as quality assessment, those studies meeting quality standards were included. In this study, diabetic patients with retinopathy were selected as the case group and those ones without DR were treated as the control group. The recessive model, allele model, additive model, heterozygote model, and homozygote model were utilized to investigate the association of three Hp gene variants and DR. Subgroup analysis on different severity of DR including nonproliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR) was also conducted. Results Six trials from different regions were finally included. A total of 1145 subjects containing 564 T2DM patients with retinopathy were included. The recessive model, allele model, additive model, and homozygote model results showed that Hp gene variants were not associated with DR, NPDR, and PDR. However, the heterozygote model indicated the association of Hp gene variants with DR. Conclusions No association was found between the Hp gene variants and PDR and NPDR. More studies are required to verify these findings.

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“…Отримані результати узгоджуються з більшістю сучасних досліджень, які демонструють пресинг гомозиготних фенотипів Hp (особливо фенотипу Hp2-2) на фізіологічні процеси. Вплив гаптоглобіну на регуляцію імунної відповіді можна пояснити його включенням у різні функції імунокомпетентних лімфоцитів, гранулоцитів і моноцитів (Sadrzadeh and Bozorgmehr, 2004;Mogarekar and Hampe, 2013).…”

Section: результати та їх обговоренняunclassified

Роль системи Hp в адаптації показників специфічного імунітету до впливу помірних фізичних навантажень

Sokolenko

2014

VDNUBM

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The aim of this study is to determine the role of haptoglobin phenotype in realization of adaptive responses of cellular and humoral immunity indices to moderate exercise caused by physical training. The study was implemented in the group of second-year students aged 18–20 who lived in the same climatic and geographical conditions for a long period of time. The students didn’t have any acute or chronic diseases and attended the main group of physical training. 60 persons were investigated. Immune system indices analysis was carried out in September before and after physical training lessons. Leukocyte level was calculated using hemocytometer, lymphocyte level was determined on the base of blood smear (dyeing for Romanowsky–Giemsa). Expression of surface antigene by peripheral blood lymphocyte was determined by immuno-fluorescence method with the use of monoclonal antibodies. The level of immunoglobulin in plasma was determined by radial immunodiffusion or Mancini method. To assess the phenotype of haptoglobin (Hp) we used the method of electrophoresis in starch gels. In the course of research we have detected the reduction of the relative and total number of lymphocytes regardless of haptoglobin phenotype in the group of students after physical training; this is a typical feature of the initial stages of stress response. We observed statistically reliable decrease in total number of analyzed subpopulations of T-lymphocyte in the group of students with phenotype Hp2-2 which was obviously the result of changes in the general level of lymphocytes in the peripheral blood. In the group of students with phenotype Hp1-1 absolute number of T-lymphocyte with phenotype CD3+ and CD4+ is reduced. In the group of students with phenotype Hp2-1 we have seen only the tendency to decrease in functional mature T-lymphocyte and their helper subpopulation. In the group of students with phenotype Hp2-2 the relative number of helper T-lymphocyte with the phenotype of CD4+ was reduced after moderate physical activity and it caused the decline in immune regulating index CD4+/CD8+. Changes of the level of B-lymphocyte with CD72+ phenotype were not found regardless of the haptoglobin phenotype. Analysis of the impact of moderate physical activity on major classes of serum immunoglobulin revealed the reduction of IgG level in the group of students with phenotype Hp2-2. Thus, we draw the conclusion that serum haptoglobin system shares the adaptive reactions of immune system to moderate physical activity. The most pressing phenotype is Hp2-2. Even in the group of students with immune pressing haptoglobin phenotypes, the analyzed parameters do not go beyond the homeostatic regulations after physical activity and it indicates satisfactory level of immune system adaptation to performed physical activity.

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Haptoglobin2-2 phenotype is an additional risk factor of retinopathy in type 2 diabetes mellitus

Cited by 8 publications

References 23 publications

Role of Haptoglobin in Health and Disease: A Focus on Diabetes

Role of Haptoglobin in Health and Disease: A Focus on Diabetes

The Association of Haptoglobin Gene Variants and Retinopathy in Type 2 Diabetic Patients: A Meta-Analysis

Роль системи Hp в адаптації показників специфічного імунітету до впливу помірних фізичних навантажень

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