Haptoglobin and Abnormal Haemoglobin Types in Sinhalese and Punjabis

Abstract

Phenotype frequencies and gene frequencies of haptoglobins and haemoglobins were assessed in Sinhalese and Punjabis, two quite different populations of the Indian subcontinent. A clinical component, a latitudinal gradient, may be discerned in the great range of Hp¹ gene frequencies that occurs in India. Haptoglobin and heamoglobin gene frequencies are compatible with but do not give clear proof of a more northerly origin of the Sinhalese.

Genetic structure of three Naikpod subpopulations of Andhra Pradesh, India

“…The low Hpl gene frequencies obtained in the present study support the contention of Sunderland et al (1976), Papiha (1973) and Bhasin et al (1983) that the gene frequency exhibits an increasing gradient from south to north in India. As seen in most of the Indian populations, the Cp locus was found to be monomorphic to the common allele CpB; and no variation was found at albumin locus in the present study.…”

“…Hp is one of the most widely studied genetic markers in Indian populations, and the Hp' gene frequency varies from 1.2% in Nandiwallas of Maharashtra (Mutalik et al, 1974) to 35% in Oraons of West Bengal (Kirk and Lai, 1961). The low Hpl gene frequencies obtained in the present study support the contention of Sunderland et al (1976), Papiha (1973) and Bhasin et al (1983) that the gene frequency exhibits an increasing gradient from south to north in India. As seen in most of the Indian populations, the Cp locus was found to be monomorphic to the common allele CpB; and no variation was found at albumin locus in the present study.…”

Serogenetic studies among an urban and two tribal populations of Orissa, India

“…The gene frequencies of the Hp system are similar in the three Orissa samples, and the Hp 1 allele frequencies (15-17%0) fit well in the geographical gradient of increasing frequency from South to North India (Papiha 1973). For the complement C3 system, though there are as yet few studies, it appears that Northwest Indian populations show a wider range of C3 F gene frequencies (5-18%0) if slightly higher than the southern and eastern states (2-9%o).…”