Genetic structure of three Naikpod subpopulations of Andhra Pradesh, India

Muralidhar, Bethi; Goud, J. D.; Murty, J. S.

doi:10.1002/ajpa.1330800106

Cited by 6 publications

(2 citation statements)

References 19 publications

(14 reference statements)

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“…Again, we express Js as Goud and Rao, 1979Muralidhar et al 1987, 1988, 1989Ramesh Babu, 1988 pers. data Goud and Rao, 1979Blake et al, 1981Pingle et al, 1981Ramesh et al.…”

Section: Hierarchical Gene Diversitymentioning

confidence: 99%

Hierarchical gene diversity and genetic structure of tribal populations of Andhra Pradesh, India

Murty

Muralidhar

Goud

et al. 1993

American J Phys Anthropol

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Gene diversity and genetic structure of tribal populations of Andhra Pradesh, India, have been analyzed under a hierarchical model consisting of five regions of the state, tribes within the regions, and local subpopulations within the tribes. Average gene diversity has been estimated from gene frequency data for 15 polymorphic loci by using nested gene diversity analysis of GST. The intralocation coefficient of gene diversity was estimated at 96% of the total, whereas the intertribal, within--and between--regional gene diversities were found to be only 1.90, 0.95, and 1.43%, respectively. The estimate of gene diversity was higher for loci with higher degrees of polymorphism such as ABO, MN, ESD, and PTC and lower for loci with low-level polymorphism and extreme gene frequencies such as Hb, Tf, PHI, 6PGD, and Hp. The nature of selective preference or neutrality at the loci seems to be important in this respect. Tribes of the plains exhibit the least gene diversity, apparently because of higher gene flow among them. The contribution of loci with intermediate gene frequencies in intertribal and regional gene diversity was found to be higher than for loci with extreme allelic frequencies. These results suggest that the most significant component of variation is between individuals within locations and that variation between local subpopulations is negligible in the genetic structure of a population. Forces like selection, gene flow and drift also influence the diversity depending upon the nature of the locus.

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“…Again, we express Js as Goud and Rao, 1979Muralidhar et al 1987, 1988, 1989Ramesh Babu, 1988 pers. data Goud and Rao, 1979Blake et al, 1981Pingle et al, 1981Ramesh et al.…”

Section: Hierarchical Gene Diversitymentioning

confidence: 99%

Hierarchical gene diversity and genetic structure of tribal populations of Andhra Pradesh, India

Murty

Muralidhar

Goud

et al. 1993

American J Phys Anthropol

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“…The distribution of GLO1 among various populations of Andhra Pradesh reveals that only GLOI*I and GLOI*2 are present except for the monomorphic nature of glyoxalase locus 1 (GLOI*2) among three Naikpod sub-populations of Andhra Pradesh (Muralidhar et al, 1989). The distribution of GLO1 among various populations of Andhra Pradesh reveals that only GLOI*I and GLOI*2 are present except for the monomorphic nature of glyoxalase locus 1 (GLOI*2) among three Naikpod sub-populations of Andhra Pradesh (Muralidhar et al, 1989).…”

Section: Resultsmentioning

confidence: 99%

Red cell enzyme polymorphism in two populations of coastal Andhra Pradesh, South India

Ramesh

Veerraju

2002

Hum. Evol.

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Correlation of geographic distributions of haptoglobin alleles with prevalence of multiple sclerosis (MS) – a narrative literature review

2016

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We have proposed that the myelin damage observed in multiple sclerosis (MS) may be partly mediated through the long-term release and degradation of extracellular hemoglobin (Hb) and the products of its oxidative degradation [Cellular and Molecular Life Sciences, 71, 1789-1798, 2014]. The protein haptoglobin (Hpt) binds extracellular Hb as a first line of defense, and can serve as a vascular antioxidant. Humans have two different Hpt alleles: Hpt1 and Hpt2, giving either homozygous Hpt1-1 or Hpt2-2 phenotypes, or a heterozygous Hpt1-2 phenotype. We questioned whether those geographic regions with higher frequency of the Hpt2 allele (conversely, lower frequency of Hpt1 allele) would correlate with an increased incidence of MS, because different Hpt phenotypes will have variable anti-oxidative potentials in protecting myelin from damage inflicted by extracellular Hb and its degradation products. To test this hypothesis, we undertook a systematic analysis of the literature on reported geographic distributions of Hpt alleles to compare them with data reported in the World Health Organization Atlas of worldwide MS prevalence. We found the frequency of the Hpt1 allele to be low in European and North American countries with a high prevalence of MS, consistent with our hypothesis. However, this correlation was not observed in China and India, countries with the lowest Hpt1 frequencies, yet low reported prevalence of MS. Nevertheless, this work shows the need for continued refinement of geographic patterns of MS prevalence, including data on ethnic or racial origin, and for new clinical studies to probe the observed correlation and evaluate Hpt phenotype as a predictor of disease variability and progression, severity, and/or comorbidity with cardiovascular disorders.

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Genetic structure of three Naikpod subpopulations of Andhra Pradesh, India

Cited by 6 publications

References 19 publications

Hierarchical gene diversity and genetic structure of tribal populations of Andhra Pradesh, India

Hierarchical gene diversity and genetic structure of tribal populations of Andhra Pradesh, India

Red cell enzyme polymorphism in two populations of coastal Andhra Pradesh, South India

Correlation of geographic distributions of haptoglobin alleles with prevalence of multiple sclerosis (MS) – a narrative literature review

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