Hantavirus Outbreak, Germany, 2007

Hofmann, Jörg; Meisel, Helga; Klempa, Boris; Vesenbeckh, Silvan; Beck, Robert; Michel, Detlef; Schmidt‐Chanasit, Jonas; Ulrich, Rainer G.; Grund, Sebastian; Enders, Gisela; Krüger, Detlev H.

doi:10.3201/eid1405.071533

Cited by 57 publications

(58 citation statements)

References 9 publications

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“…About 90 % of infections were reported in the Volga Federal District and are described as NE caused by PUUV (Garanina et al 2009). Furthermore, several outbreaks were attributed to DOBV (Klempa et al 2008). In contrast, in the Far East region HFRS cases caused by HTNV, SEOV and Amur virus were observed (Yashina et al 2000;Miyamoto et al 2003).…”

Section: Rodent-associated Hantaviruses Causing Disease In Europe Andmentioning

confidence: 99%

“…So far, it is the best characterized African hantavirus and also could be isolated (Klempa et al 2012a). Since then several further hantaviruses were described in shrews from Guinea (Tanganya virus, (Klempa et al 2007)) and Côte d'Ivoire (Azagny virus, (Kang et al 2011b)), in Muridae from Ethiopia (Tigray virus; (Meheretu et al 2012)), and in bats from Sierra Leone (Magboi virus, (Weiss et al 2012)) and Côte d'Ivoire (Mouyassué virus, (Sumibcay et al 2012)). The impact of these viruses on human health is so far almost unknown.…”

Section: Hantaviruses Described In Africa-an Actual and Growing Fieldmentioning

confidence: 99%

“…Varying local hantavirus outbreaks are reported in different years for Germany, France and Belgium as reviewed in (Essbauer et al 2013). Even in these neighbouring countries seasonal differences exist and outbreaks do not occur synchronously (Essbauer et al 2006(Essbauer et al , 2007Faber et al 2010;Mailles et al 2005;Heyman et al 2007;Ulrich et al 2008;Koch et al 2007;Hofmann et al 2008;Boone et al 2012;Ettinger et al 2012). In France, most human infections are reported during late spring and summer Sauvage et al 2002).…”

Section: Overview On Clinically Apparent Human Hantavirus Infections:mentioning

confidence: 99%

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Hantaviruses—Infections, Epidemiology and Hosts

Eßbauer

Krautkrämer

2014

Zoonoses - Infections Affecting Humans and Animals

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Hantaviruses are pathogens of emerging importance in different areas of the world with local outbreaks as reported in 2012 in the Yosemite national park in the US or in several endemic areas in Germany. Quite recently hantaviruses have also been detected on the African continent. The knowledge on respective small mammal hosts and virus types/subtypes has rapidly increased in the last years now including also insectivores, bats and with these several associated new viruses. Usually animals are asymptomatic reservoir carriers, although a few studies show effects on rodent populations. In humans clinical symptoms of hantavirus infections are depending on the virus type causing syndromes of different severity. However, as infections are often clinically inapparent, recorded case numbers may be underestimated. The epidemiology of hantaviruses is complex as multiple biotic and abiotic factors are involved, e.g. rodent population density, corresponding virus prevalence, mast, habitats, biodiversity, rodent ecology, or climate and local weather parameters.

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Section: Rodent-associated Hantaviruses Causing Disease In Europe Andmentioning

confidence: 99%

Section: Hantaviruses Described In Africa-an Actual and Growing Fieldmentioning

confidence: 99%

Section: Overview On Clinically Apparent Human Hantavirus Infections:mentioning

confidence: 99%

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Hantaviruses—Infections, Epidemiology and Hosts

Eßbauer

Krautkrämer

2014

Zoonoses - Infections Affecting Humans and Animals

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“…At the same time, vole-derived PUUV nucleotide sequences were also collected from other parts of Germany (Essbauer et al, 2007;Schilling et al, 2007). During the large PUUV outbreaks in 2007 and 2010, comprehensive molecular analyses of PUUV strains from voles and patients were carried out which led to the definition of various molecular PUUV clades corresponding to different geographical regions in Germany (Hofmann et al, 2008;Ettinger et al, 2012; see chapter 4 of this review).…”

Section: Puumala Virusmentioning

confidence: 99%

“…More comprehensive PUUV sequence data from human sources was collected in Germany during outbreaks in 2004 (Schilling et al, 2007) and 2007 (Hofmann et al, 2008). Over the last few years, HFRS cases in Germany have reached new record values with more than 2,000 reported cases in 2010 and 3,000 cases in 2012 (Robert Koch-Institut, http://www3.rki.de/SurvStat).…”

Section: Clinical Epidemiologymentioning

confidence: 99%

The broad spectrum of hantaviruses and their hosts in Central Europe

Klempa¹,

Radosa²,

Dh³

2013

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Summary. -Hantaviruses are considered to be emerging viruses due to their increasing significance as human pathogens and their cyclic reappearance during outbreaks. Central Europe is an important endemic region for hantavirus infections. Reflecting the presence of all relevant small mammals serving as reservoir hosts, close to all recognized European hantaviruses occur also in Central Europe. Important human pathogens, Puumala and Dobrava-Belgrade viruses, are present and cause hemorrhagic fever with renal syndrome of various severities. Moreover, several of the newly recognized shrew-and mole-borne hantaviruses are present. In this review, we summarize current data on molecular detection of hantaviruses in reservoir hosts as well as on molecular epidemiology of human hantavirus infections in Central Europe.

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Genetic evidence for the presence of two distinct hantaviruses associated with Apodemus mice in Croatia and analysis of local strains

Plyusnina

Krajinović

Margaletić

et al. 2010

Journal of Medical Virology

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In Europe, Dobrava‐Belgrade (DOBV), Saaremaa (SAAV), and Puumala (PUUV) viruses are known to cause hemorrhagic fever with renal syndrome (HFRS). All three hantaviruses are now found in Croatia. Lung tissue samples of 315 Apodemus mice trapped in 2003–2004 were screened for the presence of hantaviral N‐Ag and 20 mice (6.3%) were found either strongly positive or weak/suspected‐positive. Partial sequences of hantavirus M and S segments were recovered by RT‐PCR from six mice and subjected to (phylo)genetic analysis that revealed the presence of four novel strains of DOBV and one of SAAV. Curiously, one of the newly described DOBV strains was found in Apodemus agrarius mouse, that is, not in the traditional host, A. flavicollis mice, suggesting a spillover event. S segment sequences recovered previously from HFRS cases [Markotić et al., 2002] were confirmed as DOBV sequences; one of which appeared particularly close to the prototype Slovenian DOBV isolate. Taken together with earlier data on PUUV in Croatia, these results show a co‐circulation of three European hantavirus pathogens in this country. So far, not a single SAAV sequence has been recovered from HFRS patients either in Croatia or neighboring Slovenia and Hungary nor in Slovakia suggesting a somewhat lower fequency of acute SAAV infection in humans in this part of Europe than for example in the Baltics. J. Med. Virol. 83:108–114, 2011. © 2010 Wiley‐Liss, Inc.

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Hantavirus Outbreak, Germany, 2007

Cited by 57 publications

References 9 publications

Hantaviruses—Infections, Epidemiology and Hosts

Hantaviruses—Infections, Epidemiology and Hosts

The broad spectrum of hantaviruses and their hosts in Central Europe

Genetic evidence for the presence of two distinct hantaviruses associated with Apodemus mice in Croatia and analysis of local strains

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