Hantaviruses—Infections, Epidemiology and Hosts

Eßbauer, Sandra; Krautkrämer, Ellen

doi:10.1007/978-94-017-9457-2_30

Cited by 3 publications

(6 citation statements)

References 237 publications

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“…Small mammal species are a reservoir for orthohantaviruses. Orthohantaviruses are presently known to infect rodents (subfamilies Murinae, Arvicolinae, Sigmodontinae, and Neotominae), but are also detected in different shrews and moles [2][3][4]. In Eurasia, humans are infected either by rare direct contact or indirectly by inhalation of orthohantaviruses containing dust from dried excreta [5,6].…”

Section: Introductionmentioning

confidence: 99%

Molecular Characterisation and Phylogeny of Tula Virus in Kazakhstan

Tukhanova

Shin

Turebekov

et al. 2022

Viruses

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Orthohantaviruses are zoonotic pathogens that play a significant role in public health. These viruses can cause haemorrhagic fever with renal syndrome in Eurasia. In the Republic of Kazakhstan, the first human cases were registered in the year 2000 in the West Kazakhstan region. Small mammals can be reservoirs of orthohantaviruses. Previous studies showed orthohantavirus antigens in wild-living small mammals in four districts of West Kazakhstan. Clinical studies suggested that there might be further regions with human orthohantavirus infections in Kazakhstan, but genetic data of orthohantaviruses in natural foci are limited. The aim of this study was to investigate small mammals for the presence of orthohantaviruses by molecular biological methods and to provide a phylogenetic characterization of the circulating strains in Kazakhstan. Small mammals were trapped at 19 sites in West Kazakhstan, four in Almaty region and at seven sites around Almaty city during all seasons of 2018 and 2019. Lung tissues of small mammals were homogenized and RNA was extracted. Orthohantavirus RT-PCR assays were applied for detection of partial S and L segment sequences. Results were compared to published fragments. In total, 621 small mammals from 11 species were analysed. Among the collected small mammals, 2.4% tested positive for orthohantavirus RNA, one sample from West Kazakhstan and 14 samples from Almaty region. None of the rodents caught in Almaty city were infected. Sequencing parts of the small (S) and large (L) segments specified Tula virus (TULV) in these two regions. Our data show that geographical distribution of TULV is more extended as previously thought. The detected sequences were found to be split in two distinct genetic clusters of TULV in West Kazakhstan and Almaty region. TULV was detected in the common vole (Microtus arvalis) and for the first time in two individuals of the forest dormouse (Dryomys nitedula), interpreted as a spill-over infection in Kazakhstan.

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Section: Introductionmentioning

confidence: 99%

Molecular Characterisation and Phylogeny of Tula Virus in Kazakhstan

Tukhanova

Shin

Turebekov

et al. 2022

Viruses

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“…Orthohantaviruses are detected in many species of small mammals throughout the world. The viruses are mainly circulating in rodents such as Arvicolinae and Murinae , but are sometimes also found in bats or shrews (Essbauer & Krautkrämer, ; Krautkrämer, Zeier, & Plyusnin, ). Humans become infected by contact with rodents or their products: urine, saliva and faeces and by inhalation of aerosols containing virus (Hart & Bennett, ; Johnson, ; Lednicky, ).…”

Section: Introductionmentioning

confidence: 99%

“…Humans become infected by contact with rodents or their products: urine, saliva and faeces and by inhalation of aerosols containing virus (Hart & Bennett, ; Johnson, ; Lednicky, ). In general, orthohantaviruses can induce two distinct types of diseases: hantavirus cardiopulmonary syndrome (HCPS) in the Americas and haemorrhagic fever with renal syndrome (HFRS) in Europe and Asia (Essbauer & Krautkrämer, ; Schmaljohn & Hjelle, ).…”

Section: Introductionmentioning

confidence: 99%

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Serological investigation of orthohantaviruses in patients with fever of unknown origin in Kazakhstan

Tukhanova¹,

Shin²,

Abdiyeva³

et al. 2020

Zoonoses and Public Health

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Objective: Orthohantaviruses are geographically widely distributed and present various clinical manifestations from mild symptoms to the severe form of haemorrhagic fever with renal syndrome (HFRS) in Eurasia. Official registration of HFRS in Kazakhstan started in the year 2000. However, the true prevalence of human infections by orthohantaviruses within Kazakhstan is unknown. The aim of this study was to investigate of the seroprevalence of orthohantavirus infections in patients with fever of unknown origin (FUO) in two regions, Almaty and Kyzylorda region. Methods: Paired serum samples from 802 patients with FUO were screened for the presence of orthohantavirus IgG and IgM antibodies by ELISA. Positive samples were further tested by immunoblotting and indirect immunofluorescence tests (IIFT) to determine the respective orthohantavirus serotypes. Suspected acute serum samples were additionally checked by a RT-PCR to identify viral RNA. Results: In total 178/802 (22.2%) serum samples reacted with orthohantavirus IgG antibodies and 4/802 (0.5%) with IgM antibodies. All positive samples were tested by immunoblotting which resulted in 2.9% positive samples with IgG antibodies against Puumala (PUUV), Hantaan (HTNV) and Dobrava (DOBV) virus serotypes in Almaty region and 5.4% to PUUV and DOBV serotypes in Kyzylorda region, respectively.In the IFFT, 1.9% positive samples from Almaty and 3.1% from Kyzylorda were confirmed for PUUV and DOBV serotypes. Out of four IgM ELISA positive samples only three were positive against PUUV in the immunoblot and showed weak positive reactivity for the Saaremaa (SAAV), PUUV and HTNV serotypes in the IFFT. Conclusions:This study demonstrates the presence of orthohantavirus infections among patients with FUO in Kazakh regions that were so far considered as nonendemic. The healthcare system needs to be prepared accordingly in order to be capable of detecting cases and providing adequate management of patients.This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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“…PUUV causes haemorrhagic fever with renal syndrome (HFRS) and nephropathia epidemica (NE), a mild to moderate form of HFRS. It is endemic in several European countries with varying numbers of recorded cases in humans each year [ 1 , 2 ]. The natural host for PUUV is the bank vole ( Myodes ( M. ) glareolu s).…”

Section: Introductionmentioning

confidence: 99%

Identification of FactorsInfluencing the Puumala Virus Seroprevalence within Its Reservoir in aMontane Forest Environment

Thoma

Müller

Bässler

et al. 2014

Viruses

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Puumala virus (PUUV) is a major cause of mild to moderate haemorrhagic fever with renal syndrome and is transmitted by the bank vole (Myodes glareolus). There has been a high cumulative incidence of recorded human cases in South-eastern Germany since 2004 when the region was first recognized as being endemic for PUUV. As the area is well known for outdoor recreation and the Bavarian Forest National Park (BFNP) is located in the region, the increasing numbers of recorded cases are of concern. To understand the population and environmental effects on the seroprevalence of PUUV in bank voles we trapped small mammals at 23 sites along an elevation gradient from 317 to 1420m above sea level. Generalized linear mixed effects models(GLMEM) were used to explore associations between the seroprevalence of PUUV in bank voles and climate and biotic factors. We found that the seroprevalence of PUUV was low (6%–7%) in 2008 and 2009, and reached 29% in 2010. PUUV seroprevalence was positively associated with the local species diversity and deadwood layer, and negatively associated with mean annual temperature, mean annual solar radiation, and herb layer. Based on these findings, an illustrative risk map for PUUV seroprevalence prediction in bank voles was created for an area of the national park. The map will help when planning infrastructure in the national park (e.g., huts, shelters, and trails).

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Hantaviruses—Infections, Epidemiology and Hosts

Cited by 3 publications

References 237 publications

Molecular Characterisation and Phylogeny of Tula Virus in Kazakhstan

Molecular Characterisation and Phylogeny of Tula Virus in Kazakhstan

Serological investigation of orthohantaviruses in patients with fever of unknown origin in Kazakhstan

Identification of FactorsInfluencing the Puumala Virus Seroprevalence within Its Reservoir in aMontane Forest Environment

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