The broad spectrum of hantaviruses and their hosts in Central Europe

Klempa, Boris; Radosa, Lukáš; Dh, Krüger

doi:10.4149/av_2013_02_130

Cited by 38 publications

(29 citation statements)

References 51 publications

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“…While outbreaks of HFRS have long been known to occur in central Europe (Klempa et al, 2013), including Germany (Hofmann et al, 2008; Krüger et al, 2001), the Czech Republic (Pejcoch et al, 2010) and Slovakia (Sibold et al, 1999b), reports of hantavirus infection and disease in Poland have been conspicuously uncommon, despite the existence of the same reservoir rodent species. Previously, TULV was isolated from the common vole in central Poland (Song et al, 2004), and anti-hantavirus antibodies were reported among Polish mammalogists (Sadkowska-Todys et al, 2007) and forestry workers (Grygorczuk et al, 2008).…”

Section: Resultsmentioning

confidence: 99%

“…Subsequent studies have indicated that SWSV is widespread throughout Europe and Asia across the vast distribution of its soricid reservoir, in Austria, Czech Republic, Finland, Germany, Hungary, Russia, Slovakia and Slovenia (Kang et al, 2009a; Klempa et al, 2013; Korva et al, 2013; Resman et al, 2013; Schlegel et al, 2012b). SWSV has also been detected in the Siberian large-toothed shrew ( S. daphaenodon ) and tundra shrew ( S. tundrensis ) in Russia (Yashina et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Co-circulation of soricid- and talpid-borne hantaviruses in Poland

Gu¹,

Hejduk²,

Markowski³

et al. 2014

Infection, Genetics and Evolution

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Previously, we reported the discovery of a genetically distinct hantavirus, designated Boginia virus (BOGV), in the Eurasian water shrew (Neomys fodiens), as well as the detection of Seewis virus (SWSV) in the Eurasian common shrew (Sorex araneus), in central Poland. In this expanded study of 133 shrews and 69 moles captured during 2010–2013 in central and southeastern Poland, we demonstrate the co-circulation of BOGV in the Eurasian water shrew and SWSV in the Eurasian common shrew, Eurasian pygmy shrew (Sorex minutus) and Mediterranean water shrew (Neomys anomalus). In addition, we found high prevalence of Nova virus (NVAV) infection in the European mole (Talpa europaea), with evidence of NVAV RNA in heart, lung, liver, kidney, spleen and intestine. The nucleotide and amino acid sequence variation of the L segment among the SWSV strains was 0–18.8% and 0–5.4%, respectively. And for the 38 NVAV strains from European moles captured in Huta Dłutowska, the L-segment genetic similarity ranged from 94.1–100% at the nucleotide level and 96.3–100% at the amino acid level. Phylogenetic analyses showed geographic-specific lineages of SWSV and NVAV in Poland, not unlike that of rodent-borne hantaviruses, suggesting long-standing host-specific adaptation. The co-circulation and distribution of BOGV, SWSV and NVAV in Poland parallels findings of multiple hantavirus species coexisting in their respective rodent reservoir species elsewhere in Europe. Also, the detection of SWSV in three syntopic shrew species resembles spill over events observed among some rodent-borne hantaviruses.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Co-circulation of soricid- and talpid-borne hantaviruses in Poland

Gu¹,

Hejduk²,

Markowski³

et al. 2014

Infection, Genetics and Evolution

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“…This fact, in addition to the recent discovery of A. flavicollis infected with the strain DOBV or DOBVAf in southeastern Europe (the Balkan region), suggests that further phylogenetic discussions on DOBV and SAAV are required [97]. Therefore, the ICTV approved SAAV and DOBV as viral species, and more recently, the hantaviruses DOBV and SAAV have been suggested to be subdivided into four related genotypes:Dobrava, Sochi, Kurkino and Saaremaa [146]. …”

Section: Hantavirus Hostsmentioning

confidence: 99%

Hantavirus Reservoirs: Current Status with an Emphasis on Data from Brazil

Oliveira

Guterres

Fernandes

et al. 2014

Viruses

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Since the recognition of hantavirus as the agent responsible for haemorrhagic fever in Eurasia in the 1970s and, 20 years later, the descovery of hantavirus pulmonary syndrome in the Americas, the genus Hantavirus has been continually described throughout the World in a variety of wild animals. The diversity of wild animals infected with hantaviruses has only recently come into focus as a result of expanded wildlife studies. The known reservoirs are more than 80, belonging to 51 species of rodents, 7 bats (order Chiroptera) and 20 shrews and moles (order Soricomorpha). More than 80genetically related viruses have been classified within Hantavirus genus; 25 recognized as human pathogens responsible for a large spectrum of diseases in the Old and New World. In Brazil, where the diversity of mammals and especially rodents is considered one of the largest in the world, 9 hantavirus genotypes have been identified in 12 rodent species belonging to the genus Akodon, Calomys, Holochilus, Oligoryzomys, Oxymycterus, Necromys and Rattus. Considering the increasing number of animals that have been implicated as reservoirs of different hantaviruses, the understanding of this diversity is important for evaluating the risk of distinct hantavirus species as human pathogens.

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“…Hantaviral diseases have recently acquired increasing importance because of expanded spectrum of natural reservoir hosts [11][12][13][14][15]. Since there are no drugs against HTVs, vaccination remains the most desirable option for disease prevention.…”

Section: Introductionmentioning

confidence: 99%