Hantavirus Infection: Anticipation of Zoonotic Disease in Indonesia

Sendow, Indrawati; Dharmayanti, Nlpi; Saepullah, Muharam; Adjid, Rma

doi:10.14334/wartazoa.v26i1.1270

Cited by 2 publications

(2 citation statements)

References 49 publications

(96 reference statements)

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“…Pada tulisan Sendow et al (2016) sebelumnya telah dijelaskan penularan antar rodensia, rodensia ke mamalia lain, dan rodensia ke manusia, namun belum pernah dilaporkan penularan dari manusia ke manusia. Alonso et al (2020) dan Kofman et al (2018) dalam tulisannya menyebutkan bahwa virus Andes (ANDV) merupakan Hantavirus yang memiliki karakteristik berbeda dengan Hantavirus lainnya karena dapat menular antar manusia ke manusia (Alonso et al 2020) meskipun penularan masih terbatas melalui kontak dengan orang sakit (Kofman et al 2018).…”

Section: Mekanisme Penularanunclassified

Hantavirus: Structure, Mechanism of Transmission of Disease, Development of Drugs and Vaccines, and Prevention in Indonesia

Assadah¹,

Sendow²,

Dharmayanti³

2020

WARTAZOA

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Hantavirus is a zoonosis transmitted by rodents and have been spread in various countries. Hantavirus causes Hantavirus Pulmonary Syndrome (HPS) and Haemorrhagic Fever with Renal Syndrome (HFRS) in humans is still receiving worldwide attention due to the high case fatality rate. Epidemiological studies have shown that Hantavirus is widespread globally, including in Indonesia. Indonesia is an archipelago and has a tropical climate, and is crossed by the equator so that it has an enormous diversity of animals, including those that become reservoirs of Hantavirus and other vulnerable animals. The high risk of developing Hantavirus in Indonesia does not rule out the possibility of a Hantavirus outbreak if no preventive action is taken. Until now there is no effective and safe vaccine or treatment for Hantavirus. Various development efforts continue to be made to obtain an appropriate and safe vaccine to prevent and stop the spread of Hantavirus. This paper discusses Hantavirus, including its structure and mechanism of transmission, the current situation of Hantavirus in Indonesia and the efforts that can be made to prevent Hantavirus, including the development of vaccines and their drugs.

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Section: Mekanisme Penularanunclassified

Hantavirus: Structure, Mechanism of Transmission of Disease, Development of Drugs and Vaccines, and Prevention in Indonesia

Assadah¹,

Sendow²,

Dharmayanti³

2020

WARTAZOA

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“…Sendow et al [18] and the reference therein pointed out the occurrence of HPS in Indonesia. The first reported cases of HPS in humans were in 2002, and initially, all the patients were suspected of contracting DHF [19].…”

Section: Introductionmentioning

confidence: 99%

A Mathematical Model for Transmission of Hantavirus among Rodents and Its Effect on the Number of Infected Humans

Supriatna,

Napitupulu,

Ndii

et al. 2023

Computational and Mathematical Methods in Medicine

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In this paper, we present a mathematical model for the transmission of hantavirus among rodents and its effect on the number of hantavirus-infected human population. We investigate the model and present a standard analysis in mathematical epidemiology, such as determining the equilibria of the system and their stability analysis, together with the relationship to the basic reproduction number. It is found that the endemic equilibrium exists and is locally asymptotically stable when the basic reproduction number is greater than one; otherwise, the disease-free equilibrium is stable. Later on, we also show that by constructing a suitable Lyapunov function, the endemic equilibrium is globally asymptotically stable whenever it exists. Based on the basic reproduction number, we present a critical level of intervention to control the spread of the disease to humans. We found a significant finding from the present model that if the basic reproduction number is greater than one, then it is impossible to completely eliminate hantavirus disease in the system by solely focusing on any intervention for humans, like vaccination and curative action, without paying any attention to interventions for rodent populations. However, we can still decrease the density of infected humans with those interventions. Hence, we suggest that a combination of several interventions is needed to obtain effective control in eliminating the hantavirus. This information is useful for further study in finding an optimal control strategy to reduce or eliminate the transmission of hantavirus to humans.

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Hantavirus Infection: Anticipation of Zoonotic Disease in Indonesia

Cited by 2 publications

References 49 publications

Hantavirus: Structure, Mechanism of Transmission of Disease, Development of Drugs and Vaccines, and Prevention in Indonesia

Hantavirus: Structure, Mechanism of Transmission of Disease, Development of Drugs and Vaccines, and Prevention in Indonesia

A Mathematical Model for Transmission of Hantavirus among Rodents and Its Effect on the Number of Infected Humans

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