Handgrip Strength Index Predicts Nutritional Status as a Complement to Body Mass Index in Crohn’s Disease

Lu, Ze Lan; Wang, Tian Rong; Qiao, Yu; Zheng, Qing; Sun, Ying; Lü, Jun; Han, Xiao; Fan, Zhu; Ran, Zhi Hua

doi:10.1093/ecco-jcc/jjw121

Cited by 32 publications

(53 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(>30 kg for males and >20 kg for females) [46]. According to the literature, Lu et al [47] observed that HGS was lower in both males and females with CD than in controls (p < 0.001); however, HGS was also significantly higher in male CD patients with inactive disease than in those with active disease (p < 0.05), as we found.…”

Section: Discussionsupporting

confidence: 84%

Assessment of bioelectrical phase angle as a predictor of nutritional status in patients with Crohn's disease: A cross sectional study

et al. 2020

View full text Add to dashboard Cite

Background & aims: The assessment of body composition (BC) can be used to identify malnutrition in patients with Crohn's disease (CD). The aim of this study was to evaluate the nutritional status of CD patients by assessing BC, phase angle (PhA) and muscle strength. Differences in disease duration and medications were also considered. Methods: Consecutive adult CD patients aged 18e65 years were enrolled in this cross-sectional study. Disease activity was clinically defined by the Crohn's Disease Activity Index (CDAI) in the active and quiescent phases. All participants underwent anthropometry, BC and handgrip-strength (HGS) measurements; additionally, blood samples were taken. Data from CD patients were also compared with age-, sex-and BMI-matched healthy people. Results: A total of 140 CD patients with a mean age of 38.8 ± 13.9 years and a mean body weight of 64.9 ± 12 kg were recruited and compared to controls. The findings showed that all nutritional parameters, especially PhA and HGS, were lower in CD patients than in controls, and these parameters were substantially impaired as disease activity increased. Active CD patients had a lower body weight and fat mass than both the quiescent and control groups. PhA was negatively correlated with age (r ¼ À0.362; p ¼ 0.000) and CDAI (r ¼ À0.135; p ¼ 0.001) but was positively associated with fat free mass (FFM) (r ¼ 0.443; p ¼ 0.000) and HGS (r ¼ 0.539; p ¼ 0.000). Similarly, serum protein markers were lower in the active CD group than in the quiescent group (p < 0.05). Disease duration and medications did not significantly affect nutritional status. Conclusions: BIA-derived PhA is a valid indicator of nutritional status in CD patients, and its values decreased with increasing disease activity. Additionally, small alterations in BC, such as low FFM, and reduced HGS values can be considered markers of nutritional deficiency. Therefore, the assessment of BC should be recommended in clinical practice for screening and monitoring the nutritional status of CD patients.

show abstract

Section: Discussionsupporting

confidence: 84%

Assessment of bioelectrical phase angle as a predictor of nutritional status in patients with Crohn's disease: A cross sectional study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…An explanation for the same level of physical activity in daily life shown by the patients with CD as the controls is that they were evaluated during the quiescent phase of the disease, in which the symptoms that could lead to a sedentary lifestyle, such as fatigue, muscular and joint pain, and fecal incontinence, are usually absent (26) .…”

Section: Discussionmentioning

confidence: 99%

Physical Activity in Daily Life, Exercise Capacity and Quality of Life in Patients With Crohn’s Disease on Infliximab-Induced Remission: A Preliminary Study

Cabalzar

Azevedo

Lucca

et al. 2019

Arq. Gastroenterol.

View full text Add to dashboard Cite

BACKGROUND: Physical activity in daily life and exercise capacity have not been assessed in patients with Crohn’s disease to date. OBJECTIVE: To evaluate the physical activity in daily life, exercise capacity, quality of life, and prevalence of mood disorders in patients with moderate-to-severe Crohn’s disease on infliximab-induced remission and the possible associations among variables. METHODS: A cross-sectional preliminary study was conducted. Twenty-six patients with Crohn’s disease and 20 controls were selected. Participants underwent evaluation of physical activity in daily life (triaxial accelerometer), exercise capacity (shuttle walk test), handgrip strength, quality of life, and presence of mood disorders. RESULTS: The number of steps taken (7446±3081 vs 7898±2487), active time (80.6±42 vs 89.7±24.3min), shuttle walk test distance [665 (405) vs 710 (409) m] and handgrip strength [31 (15) vs 29 (20) kgf did not show any difference between the patients with Crohn’s disease and the controls. The time spent lying down [95.8 (68.8) vs 60.9 (74.7) min] was greater and some domains of the quality of life were superior in the patients with Crohn’s disease. No correlation was observed between the physical activity in daily life and quality of life or presence of mood disorders in patients with Crohn’s disease. CONCLUSION: Patients with Crohn’s disease on infliximab-induced remission, despite to more time spent lying down, they have the same level of physical activity in daily life and exercise capacity min compared with the controls.

show abstract

“…Concerning nutritional status, a gold standard for its evaluation does not exist [19]. We measured PA, HGS, BMI, and SMI and conducted a NRS 2002 nutritional risk screening to assess nutritional status because evidence for aptitude of these parameters as nutritional markers is available [17,[20][21][22][23]. To measure inflammation, we used CRP, which has been proven as a robust marker of inflammatory processes [24].…”

Section: Discussionmentioning

confidence: 99%

Role of Albumin as a Nutritional and Prognostic Marker in Elective Intestinal Surgery

Galata

Busse

Birgin

et al. 2020

Canadian Journal of Gastroenterology and Hepatology

View full text Add to dashboard Cite

Background. The aim of this study was to investigate albumin, nutritional status, and inflammation in the perioperative course of patients undergoing elective intestinal surgery. Methods. A retrospective analysis of patients with preoperative measurements of nutritional parameters who underwent intestinal surgery between April 2017 and August 2018 at our institution was performed. Preoperatively, the correlation of albumin levels with markers for inflammation and nutritional status was investigated. Postoperatively, albumin levels were assessed with regard to high-grade morbidity and inflammation. Results. A total of 105 patients were included. Preoperatively, albumin levels were correlated with both markers for nutritional status and inflammation, with phase angle (PA) (p=0.004) and C-reactive protein (CRP) (p<0.001) as independent factors predicting the albumin levels in multivariable analysis. Postoperatively, the reduction in serum albumin (∆-albumin) on postoperative day (POD) 1/2 (p=0.025) and POD 4/5 (p=0.003) was significantly associated with Clavien–Dindo complications ≥grade III. A cut-off value of 27.3% for ∆-albumin on POD 1/2 predicted postoperative high-grade morbidity (sensitivity 75% and specificity 69%). The product of ∆-albumin and CRP on POD 4/5 identified patients with major complications more reliably than ∆-albumin or CRP alone (sensitivity 91% and specificity 72%). Conclusion. Preoperatively, albumin was a marker for nutritional status even if an inflammatory component was present. Postoperatively, ∆-albumin on POD 1/2 predicted high-grade morbidity. A new marker to identify patients with major complications on POD 4/5 is presented.

show abstract

Handgrip Strength Index Predicts Nutritional Status as a Complement to Body Mass Index in Crohn’s Disease

Cited by 32 publications

References 29 publications

Assessment of bioelectrical phase angle as a predictor of nutritional status in patients with Crohn's disease: A cross sectional study

Assessment of bioelectrical phase angle as a predictor of nutritional status in patients with Crohn's disease: A cross sectional study

Physical Activity in Daily Life, Exercise Capacity and Quality of Life in Patients With Crohn’s Disease on Infliximab-Induced Remission: A Preliminary Study

Role of Albumin as a Nutritional and Prognostic Marker in Elective Intestinal Surgery

Contact Info

Product

Resources

About