Assessment of bioelectrical phase angle as a predictor of nutritional status in patients with Crohn's disease: A cross sectional study

Cioffi, Iolanda; Marra, Maurizio; Imperatore, Nicola; Pagano, Maria Carmen; Santarpia, Lidia; Alfonsi, L.; Testa, Anna; Sammarco, Rosa; Contaldo, Franco; Castiglione, Fabiana; Pasanisi, Fabrizio

doi:10.1016/j.clnu.2019.06.023

Cited by 40 publications

(24 citation statements)

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“…In patients with active CD, nutrition-particularly, enteral nutrition-can act as a primary therapy to treat intestinal inflammation, particularly in children and adolescents, and/or as a supportive therapy in the case of secondary malnutrition [6,[13][14][15][16].…”

Section: Discussionmentioning

confidence: 99%

Nutritional Rehabilitation in Patients with Malnutrition Due to Crohn’s Disease

et al. 2019

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Background: Crohn’s disease (CD) is a chronic inflammatory bowel disease frequently associated with malabsorption and secondary protein-energy malnutrition (PEM). Methods: Biochemical and clinical data of 63 (34 females, 29 males) patients with PEM due to CD sent to our outpatient unit for nutritional evaluation were retrospectively analyzed. Patients were divided into two groups, according to disease activity. Thirty-eight patients (group A) had the active disease, and 25 patients (group B) suffered from malabsorption resulting from past intestinal resections due to CD. After a physical and hemato-biochemical evaluation at the first visit, all patients received disease-specific personalized dietetic indications. When indicated, oral nutritional supplements, oral/parenteral vitamins, micronutrients, and electrolytes, up to parenteral nutrition, were prescribed. Results: After 1, 3, and 6 months of nutritional therapy, body weight, body mass index (BMI), and serum butyryl-cholinesterase significantly improved in both groups. In 8 out of 13 (61.5%) patients with a cutaneous stoma, intestinal continuity was restored. Conclusions: This study confirms the effectiveness of nutritional rehabilitation and provides information on the time required for nutritional treatment in patients with CD, both during the acute phase and after malabsorption due to intestinal resection.

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Section: Discussionmentioning

confidence: 99%

Nutritional Rehabilitation in Patients with Malnutrition Due to Crohn’s Disease

et al. 2019

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“…Malnutrition is frequently observed among patients with CD [18,19], and it is known to be associated with low muscle mass and an impaired functional status [15,17,20,21]. Recently, we have observed reduced muscle strength in CD patients compared to healthy controls, independent of disease activity and gender [21].…”

Section: Introductionmentioning

confidence: 89%

“…This cross-sectional study explored the association between HRQoL and nutritional status in patients with CD. Participants were consecutively recruited at the department of Clinical Medicine and Surgery, Federico II University Hospital, Naples (Italy) from July 2016 until March 2018; and all detailed procedures have been already described elsewhere [21].…”

Section: Design and Study Populationmentioning

confidence: 99%

“…As previously reported [21], disease severity was clinically classified by the Crohn's Disease Activity Index (CDAI), dividing patients into the active and quiescent phases (≥150 and <150, respectively). Demographic data, smoking habits, disease duration, previous surgery, drugs treatment, as well as location and disease behavior based on Montreal classification were collected.…”

Section: Design and Study Populationmentioning

confidence: 99%

“…Thus far, several studies have shown a close relationship between malnutrition and decreased quality of life in different populations [7][8][9][10][11][12][13][14], including subjects with IBD [15][16][17]. Malnutrition is frequently observed among patients with CD [18,19], and it is known to be associated with low muscle mass and an impaired functional status [15,17,20,21]. Recently, we have observed reduced muscle strength in CD patients compared to healthy controls, independent of disease activity and gender [21].…”

Section: Introductionmentioning

confidence: 99%

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Association between Health-Related Quality of Life and Nutritional Status in Adult Patients with Crohn’s Disease

et al. 2020

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This study aimed to assess health related quality of life (HRQoL) in adult patients with Crohn’s disease (CD), considering disease severity and gender differences, and also its relationship with nutritional status. Consecutive adult patients aged 18–65 years with CD were recruited. Disease activity was clinically defined by the Crohn’s Disease Activity Index (CDAI) in active and quiescent phases. HRQoL was evaluated using the validated short form (SF)-36 questionnaire for the Italian population. Additionally, anthropometry, bioimpedance analysis, and handgrip-strength (HGS) were performed. Findings showed that 135 patients (79 men and 56 women) were included, having a mean age of 38.8 ± 14 years and a BMI of 23.2 ± 3.7 kg/m2. Overall, active CD patients had a lower perception of their QoL compared to those clinically quiescent, while gender differences emerged mostly in the quiescent group. Interestingly, HRQoL was significantly associated with many nutritional variables, and muscle strength was the main predictor. Therefore, HRQoL is perceived lower in active compared to quiescent patients, but women experienced poorer QoL than men, especially in the quiescent phase. Finally, higher QoL scores were found in subjects being in clinical remission phase with a preserved muscle function. However, further studies are still required to verify these findings.

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Impact of malnutrition and sarcopenia on quality of life in patients with inflammatory bowel disease: A multicentre study

Zhang,

Gao

et al. 2023

J cachexia sarcopenia muscle

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BackgroundMalnutrition and subsequent alterations in body composition (BC), particularly sarcopenia, are common but not yet elucidated in patients with inflammatory bowel disease (IBD); we aimed to detail the changes in BC and the characteristics of co‐occurrence of malnutrition and sarcopenia in IBD patients and to investigate its effect on quality of life.MethodsThis study was a multicentre, prospective, observational study involving four tertiary referral hospitals in China. The following data were collected from consecutive IBD inpatients: demographic information, medical history, recent weight change, handgrip strength (HGS) and BC parameters by bioelectrical impedance analysis (BIA). Nutritional assessments were performed through stepwise screening (Nutritional Risk Screening 2002) and diagnosis (World Health Organization‐related body mass index [BMI], subjective global assessment, European Society for Clinical Nutrition and Metabolism 2015 and Global Leadership Initiative on Malnutrition [GLIM] criteria). The quality of life was assessed by the Inflammatory Bowel Disease Questionnaire. IBD patients were compared with 1:1 sex‐, age‐ and BMI‐matched healthy controls (MHC).ResultsA total of 238 IBD patients (177 Crohn's disease [CD] and 61 ulcerative colitis [UC]), 68.5% male, with a mean age of 38.5 ± 14.0 years and a mean BMI of 19.8 ± 3.5 kg/m2, were recruited. Compared with MHC (n = 122), IBD patients showed significant deterioration in BC and physical function, characterized by muscle depletion (appendicular skeletal muscle mass index [ASMI], 8.0 ± 1.3 vs. 6.7 ± 1.2 kg/m2, Δ% −15.0% [−22.0%, −10.0%], P < 0.001) and fat accumulation (visceral fat area, 32.9 ± 22.6 vs. 66.5 ± 35.8, Δ% 110.0% [35.0%, 201.0%], P < 0.001). The prevalence of GLIM‐defined malnutrition and sarcopenia in IBD patients was 60.1% and 25.2%, respectively. The nutritional status of patients with CD was worse than that of patients with UC. The activity phase of IBD significantly and negatively affected BC, while the lesion location did not. The co‐occurrence of sarcopenia and malnutrition was not optimistic; 16.4–21.8% of patients suffer from sarcopenia and malnutrition based on different criteria at the same time, which was accompanied by a reduction in quality of life. HGS was correlated with various BC parameters (body cell mass, r = 0.76; ASMI, r = 0.70; fat‐free mass, r = 0.73, all P < 0.001).ConclusionsGLIM‐defined malnutrition and sarcopenia were prevalent in IBD patients and kept a high rate of co‐occurrence, which was accompanied with impaired quality of life. The alteration of BC in IBD patients was characterized by muscle depletion and fat accumulation. The strong correlation between HGS and BIA‐derived BC suggested its hopeful evaluation in nutritional status and sarcopenia in IBD patients.

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Assessment of bioelectrical phase angle as a predictor of nutritional status in patients with Crohn's disease: A cross sectional study

Cited by 40 publications

References 46 publications

Nutritional Rehabilitation in Patients with Malnutrition Due to Crohn’s Disease

Nutritional Rehabilitation in Patients with Malnutrition Due to Crohn’s Disease

Association between Health-Related Quality of Life and Nutritional Status in Adult Patients with Crohn’s Disease

Impact of malnutrition and sarcopenia on quality of life in patients with inflammatory bowel disease: A multicentre study

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