Physical Activity in Daily Life, Exercise Capacity and Quality of Life in Patients With Crohn’s Disease on Infliximab-Induced Remission: A Preliminary Study

Cabalzar, Andrea Lemos; Azevedo, Felipe Meirelles de; Lucca, Fernando de Azevedo; Reboredo, Maycon Moura; Malaguti, Carla; Chebli, Julio Maria Fonseca

doi:10.1590/s0004-2803.201900000-65

Cited by 4 publications

(53 citation statements)

References 39 publications

(53 reference statements)

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“…Induction treatment with IFX resulted in a higher level of SIBDQ and improved QoL. Similar, IFX has been shown to improve QoL in CD patients [ 21 – 23 ]. Moreover, our study revealed that IFX could significantly improve BI and SE in CD patients with APF.…”

Section: Discussionmentioning

confidence: 82%

Infliximab for Crohn’s Disease Patients with Perianal Fistulas: Better Image, Better Life

et al. 2020

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Background Patients with Crohn’s disease (CD) experience physical impairments, poor quality of life and negative body image. These factors are exacerbated in CD patients with active perianal fistulas. Material/Methods Baseline characteristics were compared in retrospectively enrolled CD patients with and without active perianal fistulas. The relationships between improvements in perianal fistulas and quality of life, body image, and self-esteem were determined. The effects of infliximab treatment on improvement of psychological-social status were assessed in CD patients with active perianal fistulas. Results Of the 301 CD patients included in our institution’s database. 91 (30.2%) had active perianal fistulas. After adjustment by propensity score matching, CD patients with active perianal fistulas had lower self-esteem and more severe body image dissatisfaction than CD patients without active perianal fistulas (P<0.01 each). Perianal fistula response was closely associated with improvements in quality of life, body image dissatisfaction and self-esteem (P<0.01 each). Patients with perianal fistula treated with infliximab showed a response rate of 68.3%, significantly higher than the rate in patients with perianal fistula not treated with infliximab (P=0.005). Furthermore, improvements of life quality, body image and self-esteem were significantly greater in patients with perianal fistula who were than were not treated with infliximab (P<0.05 each). Conclusions CD patients with active perianal fistulas experience body image dissatisfaction, low self-esteem and poor quality of life. Treatment of these patients with infliximab could improve their body image, self-esteem and quality of life.

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Section: Discussionmentioning

confidence: 82%

Infliximab for Crohn’s Disease Patients with Perianal Fistulas: Better Image, Better Life

et al. 2020

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“…In addition to IBDQ, 2 studies included EuroQOL to measure QOL, 36,40 and 2 other studies measured QOL using Short Form 36 (SF-36) scale. 27,37 A direct positive relationship between QOL scores and exercise were reported in many studies; One study noted significant differences in the QOL scores between the exercise and non-exercise groups (P < 0.05). 31 Another study reported a positive correlation between QOL scores and PA which was measured using an accelerometer (P = 0.03).…”

Section: Health Outcomes Of Physical Activitymentioning

confidence: 90%

“…31 In addition, 3 studies measured PA using accelerometers. [37][38][39] Exercise advice with the help of a PA trainer was also documented in the literature. For example, one study 40 focused on exercise advice as an intervention for adults with IBD.…”

Section: Physical Activity Approachesmentioning

confidence: 99%

“…Besides self-report, several researchers directly supervised 37 Participants with CD engaged in similar PA (sitting, standing, and walking) compared to controls; adults with CD were lying down more often compared to controls.…”

Section: Physical Activity Approachesmentioning

confidence: 99%

“…Adults with IBD reported improvements in their physical and mental health outcomes, as well as better management of IBD symptoms, after initiating exercise. Majority of the reviewed studies [25][26][27]30,32,33,36,37,39,40 measured QOL using Inflammatory Bowel Disease Questionnaire (IBDQ). This is a validated instrument to measure disease specific QOL among adults with IBD.…”

Section: Health Outcomes Of Physical Activitymentioning

confidence: 99%

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An integrative review of physical activity in adults with inflammatory bowel disease

et al. 2022

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systemic symptoms, such as anxiety, depression, fatigue, sleep disturbances, and pain, are also common in adults with IBD. 4 The quality of life (QOL) of those with IBD is lowered due to the GI and systemic symptoms, as well as due to the extraintestinal manifestations. 5,6 Although, many advanced medical and surgical therapies are available to manage IBD, adults with IBD may look for other adjuvant options to manage their symptoms and improve their QOL. Physical activity (PA) is one such alternative intervention. 7 Exercise is an equivalent term used in the literature for PA, however it refers to more structured and repetitive activities. 8 Alterations in the intestinal immune system act as a trigger for IBD inflammation. 9 The anti-inflammatory benefits of exercise are well documented and are related to the control of pro-inflammatory cytokines in the intestinal system. In healthy individuals, the immune system of the intestine is in a state of

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Physical Activity in Daily Life, Exercise Capacity and Quality of Life in Patients With Crohn’s Disease on Infliximab-Induced Remission: A Preliminary Study

Cited by 4 publications

References 39 publications

Infliximab for Crohn’s Disease Patients with Perianal Fistulas: Better Image, Better Life

Infliximab for Crohn’s Disease Patients with Perianal Fistulas: Better Image, Better Life

An integrative review of physical activity in adults with inflammatory bowel disease

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