Halothane Anesthesia as a Possible Cause of Massive Hepatic Necrosis

Brody, Gerald L.; Sweet, Robert B.

doi:10.1097/00000542-196301000-00005

Cited by 102 publications

(18 citation statements)

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“…Halothane has been shown to be relatively nontoxic to the liver in animal experimentation (2, 15) although severe hepatic necrosis has been reported in clinical situations (16,17) after repeated exposure. Fluroxene has been thought to be a relatively safe agent since no modifications of liver function tests have heretofore been observed (1).…”

Section: ( P < O O L )mentioning

confidence: 99%

Effect of Anesthetic Drugs on Lysosomal Enzymes in the Rat

Bc¹,

Ja²,

Rl³

1971

Experimental Biology and Medicine

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Section: ( P < O O L )mentioning

confidence: 99%

Effect of Anesthetic Drugs on Lysosomal Enzymes in the Rat

Bc¹,

Ja²,

Rl³

1971

Experimental Biology and Medicine

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“…Knowledge of the features of a cancer cell and its metabolism enables us to predict the direction of chemical and biological research, to conduct a targeted synthesis of potential drugs, and to assess their applicability in oncological practice as anti-tumor agents. One of the most successful directions of search for new anti-tumor agents is the study of antimetabolites of pyrimidine and purine exchange, which acts as preformed compounds in several biosynthetic processes (DNA and RNA-specific proteins) inhibiting tumor growth (Abou-Gharbia & Patel-Usha, 1988;Аlоnso, Shaw, Wright, 1984;Perevodchikova, 2005;Brody & Sweet, 1963;Brown & Sipes, 1977).…”

Section: Introductionmentioning

confidence: 99%

Anti-Tumor Activity of Bacterial Lectin and 5-Methyluracil Adduct

Welchinska

2014

CBUP

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Abstract:The synthesis was performed using 5-methyluracil mono-and bis-derivatives with the halogencontaining pharmacophore groups in the composition of molecules; their physiochemical and biological properties were studied. These reactions are a typical example of substitution reactions on heteroatom N (1) of uracil molecule using as the second component the reaction of halothane-the known inhaled anesthetic. The reactions were carried out in a solvent system: benzene-dimethyl formamide and diethyl ether, under conditions of phase transfer catalysis DB-18-crown-6-complex (alkaline medium), by heating from 2 to 11 hours, followed by purification, and drying of the resulting products.The structure of the synthesized compounds was confirmed by elemental analysis, IR and 1 HNMR spectra. The purity was controlled by the methods of thin-layer and gas-liquid chromatography. Chromatography, IR and 1 HNMR spectra of the final products were identified in comparison with the chromatograms, IR and 1 HNMR spectra of the initial compounds. Variation of the reaction conditions and changes in methods of synthesis enabled to receive the synthesized compounds of high purity and to increase their practical output up to 43-80%. Molecular complex of Bacterial lectin and 5-methyluracil bis-derivative was obtained.The toxicity and anti-tumor activity of some of the synthesized compounds were investigated. We have found that the new molecular complex of Bacterial lectin and 5-methyluracil bis-derivative has high antitumor activity in Limphosarcoma Plissa-62.8% (activity criterion > 50%), which allows us to consider the synthesized compound as a physiologically active compound with the prospect for further study as a potential vehicle for anti-tumoral treatment in patients.

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“…Halothane has been reported to induce hepatic injury [1,2]. This injury has two types: the mild type is seen in 20% of patients (3), and the fulminant type in approximately 1 of 10,000 patients [4].…”

Section: Introductionmentioning

confidence: 99%