Hair analysis for diphenhydramine after surreptitious administration to a child

Kintz, Pascal; Evans, Julie; Villain, Marion; Salquèbre, Guillaume; Cirimele, Vincent

doi:10.1016/j.forsciint.2006.12.006

Cited by 28 publications

(7 citation statements)

References 12 publications

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“…Chronic administration of drugs for criminal gain has been reported 142,151 but by far the most common DFC reported is DFSA. This presents investigators with a considerable challenge as the identification of a single dose requires sensitive instrumentation to detect low pg/mg levels in hair.…”

Section: Drug-facilitated Crimementioning

confidence: 99%

Hair testing is taking root

Cooper

2011

Ann Clin Biochem

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An increasing number of toxicology laboratories are choosing to expand the services they offer to include hair testing in response to customer demands. Hair provides the toxicologist with many advantages over conventional matrices in that it is easy to collect, is a robust and stable matrix that does not require refrigeration, and most importantly, provides a historical profile of an individual's exposure to drugs or analytes of interest. The establishment of hair as a complementary technique in forensic toxicology is a direct result of the success of the matrix in medicolegal cases and the wide range of applications. However, before introducing hair testing, laboratories must consider what additional requirements they will need that extend beyond simply adapting methodologies already validated for blood or urine. Hair presents many challenges with respect to the lack of available quality control materials, extensive sample handling protocols and low drug concentrations requiring greater instrument sensitivity. Unfortunately, a common pitfall involves over-interpretation of the findings and must be avoided.

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Section: Drug-facilitated Crimementioning

confidence: 99%

Hair testing is taking root

Cooper

2011

Ann Clin Biochem

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“…Un premier cas rapporte l'administration de bromazépam à une fillette de 8 ans dans un but d'agression sexuelle [4]. Une autre observation concerne une fillette de 9 ans droguée par la diphénydramine [5]. Cette même équipe décrit également l'administration de trimépra-zine, médicament antihistaminique H1, à deux enfants, l'administration de scopolamine à 3 enfants d'une même fratrie dans un but de sédation ou un cas fatal concernant un adolescent de 14 ans abusé sexuellement après absorption de bupré-norphine [6,8].…”

Section: Discussionunclassified

Soumission chimique chez l'enfant : à propos d'un cas chez une fillette de 8 ans diagnostiqué en milieu hospitalier

Lemaire-Hurtel¹,

Durand-Maugard²,

Devolder

et al. 2008

Ann Toxicol Anal

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Résumé - Mots clés : Soumission chimique, CL-SM/SM, enfantAbstract -Introduction: The case of an 8-year-old girl brought to the emergency department of an hospital is reported below. Patient and methods: The girl had difficulties walking; she was euphoric and had auditory hallucinations. A blood sample was taken and a toxicological screening asked. The routine blood screening for the different psychotropic drugs and acetaminophen turned out to be negative. Results: The blood alcohol level was 0.3 g/L. The screening was positive for valproic acid (140 mg/L). Discussion: As the child was not known for undergoing a treatment, the paediatric department was contacted. The girl reported having difficulties to fall asleep the previous night. She said that her stepfather gave her a "white tablet". Despite this, she woke up later that night. So she said that he then gave her 3 "pink pills" and 3 "white pills" with a nasty tasting drink. Benzodiazepines with their metabolites (n = 27) and sedative drugs (n = 18) known to be used for chemical submission were tested for detection and assays by LC-MS/MS. It revealed nordiazepam and alprazolam in blood and urine and oxazepam and hydroxy-alprazolam only in urine. Conclusion: In this case, valproic acid and ethanol in the blood sample allowed giving the alert. Moreover this case confirms that chemical submission is not only a legal issue. Hospitals should also be aware of this problem.

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“…In fact, results obtained in hair analysis helped to demonstrate the surreptitious administration of diphenhydramine to eight victims of sexual abuse [69]. In fact, results obtained in hair analysis helped to demonstrate the surreptitious administration of diphenhydramine to eight victims of sexual abuse [69].…”

Section: Dfc In Childrenmentioning

confidence: 95%

Forensic Applications of Hair Analysis

Jurado

2015

Hair Analysis in Clinical and Forensic Toxicology

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Hair analysis for diphenhydramine after surreptitious administration to a child

Cited by 28 publications

References 12 publications

Hair testing is taking root

Hair testing is taking root

Soumission chimique chez l'enfant : à propos d'un cas chez une fillette de 8 ans diagnostiqué en milieu hospitalier

Forensic Applications of Hair Analysis

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