Soumission chimique chez l'enfant : à propos d'un cas chez une fillette de 8 ans diagnostiqué en milieu hospitalier

Abstract

Résumé - Mots clés : Soumission chimique, CL-SM/SM, enfantAbstract -Introduction: The case of an 8-year-old girl brought to the emergency department of an hospital is reported below. Patient and methods: The girl had difficulties walking; she was euphoric and had auditory hallucinations. A blood sample was taken and a toxicological screening asked. The routine blood screening for the different psychotropic drugs and acetaminophen turned out to be negative. Results: The blood alcohol level was 0.3 g/L. The screening was positive for valproic acid (140 mg/L). Discussion: As the child was not known for undergoing a treatment, the paediatric department was contacted. The girl reported having difficulties to fall asleep the previous night. She said that her stepfather gave her a "white tablet". Despite this, she woke up later that night. So she said that he then gave her 3 "pink pills" and 3 "white pills" with a nasty tasting drink. Benzodiazepines with their metabolites (n = 27) and sedative drugs (n = 18) known to be used for chemical submission were tested for detection and assays by LC-MS/MS. It revealed nordiazepam and alprazolam in blood and urine and oxazepam and hydroxy-alprazolam only in urine. Conclusion: In this case, valproic acid and ethanol in the blood sample allowed giving the alert. Moreover this case confirms that chemical submission is not only a legal issue. Hospitals should also be aware of this problem.

Crises convulsives inexpliquées chez un nouveau-né : évoquer le syndrome de Munchausen par procuration

“…La linéarité s'étend de la LOQ à 100 ou 200 ng/mL dans ce milieu en fonction des molécules. Les coefficients de variation de la méthode sont tous inférieurs à 15 % [2].…”