Haematological and biochemical changes in experimental Trypanosoma evansi infection in rabbits

Sivajothi, S.; Rayulu, V. C.; Reddy, B. Sudhakara

doi:10.1007/s12639-013-0321-6

Cited by 46 publications

(54 citation statements)

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“…Hypoglycaemia was noticed in these dogs and it is due to utilization of blood glucose by parasites in circulation. Observed reduced serum albumin levels were may be due to decreased liver biosynthesis and progressive loss of albumin in urine [4]. Due to tissue damage and kidney dysfunction, uremia and elevated creatinine levels were noticed in the present study [8].…”

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confidence: 54%

Therapeutic Management of Anemia Due to Trypanosomosis in Dogs

Sivajothi

2017

ICPJL

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Trypanosomosis is one of the fatal diseases in canines. Inappropriate usage of the trypanosomacidal drugs leads to development of the resistance organisms. Present communication report the successful treatment of the clinical trypanosomosis with two doses of injection diminazene aceturate at the rate of 3.5 mg per kg body weight intramuscularly. Two dogs with clinical trypanosomosis were noticed with the signs of fever; tachycardia and tachypnea congested mucus membranes, corneal opacity and enlarged lymph nodes. Dogs revealed lowered the red blood cell count, hemoglobin, packed cell volume, serum total protein; albumin and glucose levels. Trypanosoma evansi organisms were noticed in the blood smears. The clinical and biochemical improvement was recorded in both the dogs and dogs were free from anemia after one month of therapy.Keywords: Anaemia; Trypanosoma evansi; Dog; Diminazene aceturate and micrometry it was confirmed as Trypanosoma evansi [5]. Haematological finding were in two dogs were as haemoglobin (6.6, 5.4g/dL), total erythrocyte count (3.4 X 10 6 , 3.1 X 10 6 µL), packed cell volume (18%, 17.4%) and higher total leucocyte count (9800, 11200/µL), neutrophils (42-38%), eosinophils (6-4%), lymphocytes (51,57%) and monocytes (1,1%). Biochemical findings were glucose (53,68mg/dL), total protein (5.43, 5.66mg/ dL), albumin (1.79, 1.62mg/dL), blood urea nitrogen (48.12, 56.60mg/dL) and creatinine (2.20, 2.86mg/dL). Recorded haemato-biochemical findings before and after therapy were presented in the Table 1. By the seventh day of treatment, clinical signs were disappeared and the parasites were not found in blood smears. The severity of canine trypanosomosis ranges from acute, subacute to chronic forms. In dogs an acute and fatal type is commonly seen and death possibly occurs in 2-4 weeks after infection. During the course of pathogenesis, organisms enter host cells after infection, multiplies sub-clinically, escapes the immune system and parasitemia develops within a few days and peaks 2 to 3 weeks post-infection [6]. During the chronic infection, progressive weakness, anorexia, anaemia, intermittent fever, conjunctivitis, swelling of limbs, enlarged superficial lymph nodes and bilateral corneal opacity are noticed [7]. Haemato-biochemical findings observed in the present study were in according with the previous studies and the anaemic changes are attributable to extra vascular destruction of red blood cell which may be through the process of erythrophagocytosis or metabolic product and toxins liberated from the parasites. Hypoglycaemia was noticed in these dogs and it is due to utilization of blood glucose by parasites in circulation. Observed reduced serum albumin levels were may be due to decreased liver biosynthesis and progressive loss of albumin in urine [4]. Due to tissue damage and kidney dysfunction, uremia and elevated creatinine levels were noticed in the present study [8]. Diminazene aceturate is the commonly used drug to control trypanosomosis in animals in Africa which have been in ...

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Therapeutic Management of Anemia Due to Trypanosomosis in Dogs

Sivajothi

2017

ICPJL

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“…In the present days, rabbits are used for good quality protein diet, pets in the houses and used for the research studies as laboratory animals (Sivajothi et al 2013a). Coccidiosis is a ubiquitous protozoan infection of animals seriously impairing their growth and it causes significant mortality in domestic rabbits (El-Akabawy et al 2004).…”

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confidence: 99%

Study on impression smears of hepatic coccidiosis in rabbits

2014

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Hepatic coccidiosis is a contagious and lethal disease condition in rabbits. The disease was recorded in six rabbits suffering with watery diarrhoea. Clinically, affected rabbits showed decreased growth rate, anorexia, debilitation, diarrhea and rough hair coat. Examination of the faecal samples revealed the presence of unsporulated oocysts of Eimeria spp. After sporulation Eimeria stiedae oocysts were identified. Postmortem examination revealed hepatomegaly with presence of discrete yellowish-white nodules on the surface of the liver. Impression smears from the liver revealed the presence of numerous developmental stages of E. stiedae corresponding with the stage of the liver lesion and also represent the histological changes of the liver. Rabbits were treated with a combination of sulphaquinoxaline and diaveridine for five days.

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“…Prevalence of T.evansi was recorded in different species of animals by different diagnostic methods in India [2,3]. Haematological and biochemical abnormalities were also recorded in experimental animal infection with T.evansi [4]. Little is known about the haematological changes associated with the local strain of T.evansi in cattle in Andhra Pradesh.…”

Section: Introductionmentioning

confidence: 99%

Haematological changes in Trypanosoma evansi infected cattle

Sivajothi

Reddy²,

Kumari³

et al. 2014

International Journal of Scientific World

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During the three years period of study twelve cross bred cattle were identified that they were suffering with clinical Trypanosomiasis. Up on clinical examination cattle had anorexia, fever, ocular discharges, dullness and enlarged lymph nodes. Stained peripheral blood examination revealed the presence of Trypanosoma evansi. Haematological abnormalities include decreased TEC, PCV, Hb and TLC values (P<0.01). The present leucopaenia was characterized by neutrophilia, eosinophilia and lymphocytopaenia (P>0.05).

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Haematological and biochemical changes in experimental Trypanosoma evansi infection in rabbits

Cited by 46 publications

References 20 publications

Therapeutic Management of Anemia Due to Trypanosomosis in Dogs

Therapeutic Management of Anemia Due to Trypanosomosis in Dogs

Study on impression smears of hepatic coccidiosis in rabbits

Haematological changes in Trypanosoma evansi infected cattle

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