Haemato-Biochemical Aspects of Foot and Mouth Disease in Cattle in Chittagong, Bangladesh

Abstract

| During an outbreak of Foot and Mouth Disease (FMD) blood samples were collected from clinically diseased (n=10) and healthy (n=10) cattle and analysed for various hemato-biochemical parameters. Results indicated a significant increase in packed cell volume (PCV) (28.6 ± 0.98%, P=0.036), lymphocytes (70.2 ± 6.20%, P=0.0132), monocytes (8.2 ± 1.08%, P=0.0132) and serum glucose (104.2 ± 15.59 mg/dL, P=0.0053) whereas a significant decrease in the concentration of hemoglobin (7.17 ± 0.07 gm/dL, P=0.0004), basophils (0.3 ± 0.16%, P=0.0241), eosinophils (16.5 ± 1.83%, P=0.0097), calcium (8 ± 0.41 mg/dL, P=0.0125) and total protein (6.2 ± 0.19 mg/dL, P=0.0058) was recorded in FMD infected cattle. Non-significant (P >0.05) difference was noted between healthy and FMD infected animals with respect to total erythrocyte count (TEC) (P=0.6066), total leukocyte count (TLC) (P=0.3169), neutrophils (P=0.2358) and serum inorganic phosphorous (P=0.2507). It was concluded that FMD had major impact on hemato-biochemical profile of affected animals.

Molecular Diagnosis of Foot and Mouth Disease Virus in Cattle with Reference to Hematological and Biochemical Changes

“…The neutrophils and other phagocytic cells are the first line of defense against microbial and viral infections. Our results are partially consistent with those previously reported [31,[36][37][38].…”

“…Myocardial degeneration was considered the main cause for serum CK, AST and LDH elevation [40,57]. Our results were consistent with other studies [7,31,38].…”

“…Serum concentrations of MDA and NO were significantly increased in all FMDVinfected animals at different ages. The significant increases in MDA level were in agreement with Kar et al [38]. Nitrate and nitrite in serum are formed by the decomposition of NO and their concentrations in serum are used as a direct measure of NO production [53][54][55].…”