Haemato-Biochemical Alterations in Subacute Oral Toxicity of Sodium Fluoride in Wistar Rats

Giri, Devesh Kumar; Ghosh, R. C.; Kashyap, Deepak; Dewangan, Govina; Maiti, S. K.

doi:10.5958/2277-940x.2015.00100.x

Cited by 4 publications

(8 citation statements)

References 2 publications

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“…Our studies showed significant decrease in erythrogram indices, i.e. RBC, Hb, and PCV during NaF exposure as compared to control days, which was in concord with study done in past (Giri et al 2015). Sodium fluoride has the potential to cause destruction of haemopoietic tissue (Patel and Dhande 2000).…”

Section: Resultssupporting

confidence: 87%

Protective effects of melatonin against fluoride-induced oxidative stress in rats at high altitude

Vivek¹,

Bharti²,

Kalia³

et al. 2019

Indian J of Anim Sci

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This study was conducted to evaluate the protective effects of melatonin against fluoride-induced oxidative stress-mediated haematological and biochemical changes in rat at high altitude. Adult male Wistar rats (6) were given the basal diet and drinking water ad lib. for first 7-days which was considered as the control period. Thereafter, they were exposed to NaF (@ 50 ppm) per-oral through drinking water for the next 14 days followed by melatonin treatment (@ 15 mg/kg BW, p.o.) for the next 14 days. The result showed induction of oxidative stress during NaF treatment alone, which caused significant increase in alkaline phosphatase (ALP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) activity, and % inhibition of DPPH, MDA, and water intake. Whereas, total antioxidant capacity (FRAP) and body weight gain were significantly reduced during NaF exposure. Haemogram analysis indicated significant decrease in haemoglobin, packed cell volume, erythrocytes, lymphocytes, platelets count, whereas increase in MCH, monocytes, neutrophil, and eosinophil during NaF exposure. However, melatonin administration after 14 days of fluoride treatment resulted in significant amelioration of adverse changes occurred in different blood-biochemical parameters and also increased the total antioxidant status. Notably, the body weight gain improved during melatonin administration. These findings indicated induction of oxidative stress-mediated adverse change in haematology and biochemical parameters, and amelioration effect of oral dose of melatonin in rats under high altitude stress condition. Hence it can be concluded that melatonin acts as a potent antioxidant agent, which may be orally supplemented for amelioration of fluoride-mediated oxidative stress even under prevalent high altitude stress.

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Section: Resultssupporting

confidence: 87%

Protective effects of melatonin against fluoride-induced oxidative stress in rats at high altitude

Vivek¹,

Bharti²,

Kalia³

et al. 2019

Indian J of Anim Sci

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“…Giri et al, [42] reported that oral administration of NaF at three dose levels to Wistar rats for 28 days caused a dose-dependent elevation in plasma enzyme activities of ALT, AST, and ALP, hypoproteinaemia and hypoglobulinaemia in rats treated with NaF as compared to control group.…”

Section: B 2 Effect Of Sodium Fluoride On the Liver Functionmentioning

confidence: 99%

“…ALP is a marker enzyme of fluoride toxicosis and bone pathology. The increase in the activity of ALP might be due to the fluoride-induced cell injury to osteoblasts and osteocytes to initiate a repair response resulting in an increased proliferation of osteoblasts, matrix formation and ALP production [42].…”

Section: B 2 Effect Of Sodium Fluoride On the Liver Functionmentioning

confidence: 99%

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Sodium Fluoride Induces Hepato-Renal Oxidative Stress and Pathophysiological Changes in Experimental Animals

Azab¹,

Albasha²,

Jbireal³

et al. 2018

OJApo

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The liver is a primary site for xenobiotics detoxification, and its metabolism is readily altered by toxicity. The kidney is a common target for toxic xenobiotics due to its capacity to extract and concentrate toxic substances by highly specialized cells. So, they are the target organs of sodium fluoride toxicity. The aim of this review is to highlight on hepatorenal oxidative stress and pathophysiological changes induced by treatment of experimental animals with sodium fluoride. Our review shows fluoride toxicosis caused an elevation in the serum activities of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lactate dehydrogenase, acid phosphatase, and the level of total bilirubin, and reduction in the serum levels of total protein, albumin, and globulins, and serious histopathological changes in the hepaic tissues. Also, NaF administration caused increases in serum urea, creatinine, uric acid, sodium ions, and chloride ions levels and serious histopathological changes in the kidney tissues. Treatment of experimental animals with NaF induced oxidative stress in hepatic and renal tissues. It can be concluded that administration of sodium fluoride to experimental animals induced oxidative stress, serious hepatorenal histopathological changes, and disturbance in liver and kidney functions. So, human should be advised to decrease exposure to sodium fluoride to decrease the harmful effects of NaF on liver and kidney.

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“…The results of present study were consistent with those of (16) who noted in their study, of the effect of taking fluoride with feeding, that exposure to fluoride leads to an excessive increase in blood urea concentration besides creatinine, This was due to the inefficiency of kidneys in expelling toxic substances and reabsorbing minerals and non-metallic ions. In the same direction, (17) , pointed out that exposure to fluoride leads to a significant increase in the concentration of urea and creatinine and that was caused by the occurrence of renal failure. The results of current study confirmed those of (16) , increased serum creatinine concentration.…”

Section: Toxic Effects Of Sodium Fluoridementioning

confidence: 95%

Study of the preventive role of cranberry extract on some physiological parameters in male rate induced by sodium fluoride

Azez¹,

Hamza²

2020

ATMPH

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Background: Traditional medicine is still widely practiced today and modern medicine benefits from many compounds. The aim of current study was to determine the biological efficacy of the cranberry plant extract on some blood parameters specific to renal function in laboratory white rats (Rattus norvegicus), orally injected with sodium fluoride. . Methods: Current study was conducted over a period of one month, from February 2019 to July 2019. The laboratory white strain inventory was studied (albino rats, n= 25) inventory of males aged between (2-4) months and weighed between (150-250g). They were divided into five groups randomly; the first group included negative control group, the second group included positive control administered an oral dose of sodium fluoride (20mg/kg body weight) for 30 respective days. Groups III and IV were considered as test groups for the protective role of cranberry extract which were administered oral doses of cranberry extract (225, 150 and 75(mg/kg body weight plus sodium fluoride for 30 respective days. After the end of the experiment, animals were anesthetized with ketamine and the blood was collected by direct heart puncture.. The studied parameters included (body weight and serum concentrations of sodium, calcium, potassium, urea and creatinine. Results: The results of present study showed significant differences in the studied parameters. A significant increase was observed in the concentration of sodium, potassium, calcium, creatinine and urea. Also, a significant decrease was observed in the body weight (P≤0.05) in rats treated with sodium fluoride when compared to the control group. On the other hand, the results of the current study showed that the treatment with cranberry extract was accompanied by some significant changes. A significant decrease was observed in body weight and concentrations of sodium, calcium, potassium and creatine (P≤0.05). When comparing the fluoride and the cranberry extract groups, the decrease led to return of these parameters closer to the state in the control group. However, the concentration of urea was increased significantly (P≤0.05) when comparing the fluoride group with the cranberry extract group. Conclusion: It was clear from the results of this study that the extract of the Cranberry plant has a biological effect in resisting the effects of toxic substances to which the organism is exposed.

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Haemato-Biochemical Alterations in Subacute Oral Toxicity of Sodium Fluoride in Wistar Rats

Cited by 4 publications

References 2 publications

Protective effects of melatonin against fluoride-induced oxidative stress in rats at high altitude

Protective effects of melatonin against fluoride-induced oxidative stress in rats at high altitude

Sodium Fluoride Induces Hepato-Renal Oxidative Stress and Pathophysiological Changes in Experimental Animals

Study of the preventive role of cranberry extract on some physiological parameters in male rate induced by sodium fluoride

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