Study of the preventive role of cranberry extract on some physiological parameters in male rate induced by sodium fluoride

Abstract

Background: Traditional medicine is still widely practiced today and modern medicine benefits from many compounds. The aim of current study was to determine the biological efficacy of the cranberry plant extract on some blood parameters specific to renal function in laboratory white rats (Rattus norvegicus), orally injected with sodium fluoride. . Methods: Current study was conducted over a period of one month, from February 2019 to July 2019. The laboratory white strain inventory was studied (albino rats, n= 25) inventory of males aged between (2-4) months and weighed between (150-250g). They were divided into five groups randomly; the first group included negative control group, the second group included positive control administered an oral dose of sodium fluoride (20mg/kg body weight) for 30 respective days. Groups III and IV were considered as test groups for the protective role of cranberry extract which were administered oral doses of cranberry extract (225, 150 and 75(mg/kg body weight plus sodium fluoride for 30 respective days. After the end of the experiment, animals were anesthetized with ketamine and the blood was collected by direct heart puncture.. The studied parameters included (body weight and serum concentrations of sodium, calcium, potassium, urea and creatinine. Results: The results of present study showed significant differences in the studied parameters. A significant increase was observed in the concentration of sodium, potassium, calcium, creatinine and urea. Also, a significant decrease was observed in the body weight (P≤0.05) in rats treated with sodium fluoride when compared to the control group. On the other hand, the results of the current study showed that the treatment with cranberry extract was accompanied by some significant changes. A significant decrease was observed in body weight and concentrations of sodium, calcium, potassium and creatine (P≤0.05). When comparing the fluoride and the cranberry extract groups, the decrease led to return of these parameters closer to the state in the control group. However, the concentration of urea was increased significantly (P≤0.05) when comparing the fluoride group with the cranberry extract group. Conclusion: It was clear from the results of this study that the extract of the Cranberry plant has a biological effect in resisting the effects of toxic substances to which the organism is exposed.