Há equidade na produção do conhecimento sobre as doenças negligenciadas no Brasil?

Andrade, Bruno Leonardo Alves de; Rocha, Dais Gonçalves

doi:10.18569/tempus.v9i3.1783

Cited by 4 publications

(4 citation statements)

References 5 publications

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“…According to some studies in Latin American countries, Brazil has the highest rate of neglected diseases, and a large part of the Brazilian population both above and below the poverty line suffers from some of these diseases [7–9].…”

Section: Introductionmentioning

confidence: 99%

Active Essential Oils and Their Components in Use against Neglected Diseases and Arboviruses

Luna

Scotti

et al. 2019

Oxidative Medicine and Cellular Longevity

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The termneglected diseasesrefers to a group of infections caused by various classes of pathogens, including protozoa, viruses, bacteria, and helminths, most often affecting impoverished populations without adequate sanitation living in close contact with infectious vectors and domestic animals. The fact that these diseases were historically not considered priorities for pharmaceutical companies made the available treatments options obsolete, precarious, outdated, and in some cases nonexistent. The use of plants for medicinal, religious, and cosmetic purposes has a history dating back to the emergence of humanity. One of the principal fractions of chemical substances found in plants are essential oils (EOs). EOs consist of a mixture of volatile and hydrophobic secondary metabolites with marked odors, composed primarily of terpenes and phenylpropanoids. They have great commercial value and were widely used in traditional medicine, by phytotherapy practitioners, and in public health services for the treatment of several conditions, including neglected diseases. In addition to the recognized cytoprotective and antioxidative activities of many of these compounds, larvicidal, insecticidal, and antiparasitic activities have been associated with the induction of oxidative stress in parasites, increasing levels of nitric oxide in the infected host, reducing parasite resistance to reactive oxygen species, and increasing lipid peroxidation, ultimately leading to serious damage to cell membranes. The hydrophobicity of these compounds also allows them to cross the membranes of parasites as well as the blood-brain barrier, collaborating in combat at the second stage of several of these infections. Based on these considerations, the aim of this review was to present an update of the potential of EOs, their fractions, and their chemical constituents, against some neglected diseases, including American and African trypanosomiasis, leishmaniasis, and arboviruses, specially dengue.

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Section: Introductionmentioning

confidence: 99%

Active Essential Oils and Their Components in Use against Neglected Diseases and Arboviruses

Luna

Scotti

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…Of the countries that make up the Latin America and the Caribbean region, Brazil has the greatest number of cases of neglected 'tropical' diseases, and these diseases constitute a public health problem in the country [24,25]. The Brazilian health system consists of a hybrid public-private structure formed by a complex network of service providers and purchasers distributed in three subsectors [26]:…”

Section: The Context Of Healthcare and Scd In Brazilmentioning

confidence: 99%

Sickle Cell Disease in Bahia, Brazil: The Social Production of Health Policies and Institutional Neglect

2022

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A disease is considered neglected when it is not given due priority in health policies despite the social relevance of that disease, either in terms of the number of individuals affected by it or its morbidity or mortality. Although the causes are structural, neglect in health does not occur in a vacuum. In this paper, we explore how sickle cell disease (SCD) is constructed and neglected in Brazil, based on insights from our long-term participatory qualitative research in the state of Bahia. We present five overarching themes relevant to the social production of SCD, and associated health policies in Brazil: (1) The achievements and setbacks to overcome neglect in SCD, (2) Continuity of comprehensive SCD care; (3) Social movements of people with SCD; (4) Biocultural citizenship; and (5) Academic advocacy. We conclude that it is insufficient to merely recognize the health inequities that differentiate white and black populations in Brazil; racism must be understood as both a producer and a reproducer of this process of neglect. We conclude with a set of recommendations for the main SCD stakeholder groups committed to improving the lives of people living with SCD.

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“…Other studies have described NTD research funding in Brazil, but have only analyzed research funded by specific requests for research on NTDs and not investment evolution over the years [12,17,18]. As such, the present study assessed the evolution of NTD research funding from the Ministry of Health and its partners in relation to investment continuity, diseases studied and the burden of these diseases in Brazil, from 2004 to 2020.…”

Section: Introductionmentioning

confidence: 99%

Evolution of research funding for neglected tropical diseases in Brazil, 2004–2020

et al. 2023

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Neglected tropical diseases are a global public health problem. Although Brazil is largely responsible for their occurrence in Latin America, research funding on the subject does not meet the population’s health needs. The present study analyzed the evolution of research funding for neglected tropical diseases by the Ministry of Health and its partners in Brazil, from 2004 to 2020. This is a retrospective study of data from investigations registered on Health Research (Pesquisa Saúde in Portuguese), a public repository for research funded by the Ministry of Health’s Department of Science and Technology. The temporal trend of funding and the influence of federal government changes on funding were analyzed using Prais-Winster generalized linear regression. From 2004 to 2020, 1,158 studies were financed (purchasing power parity (PPP$) 230.9 million), with most funding aimed at biomedical research (81.6%) and topics involving dengue, leishmaniasis and tuberculosis (60.2%). Funding was stationary (annual percent change of -5.7%; 95%CI -54.0 to 45.0) and influenced by changes to the federal government. Research funding was lacking for chikungunya, Chagas disease, schistosomiasis, malaria and taeniasis/cysticercosis, diseases with a high prevalence, burden or mortality rates in Brazil. Although the Ministry of Health had several budgetary partners, it was the main funder, with 69.8% of investments. The study revealed that research funding for neglected tropical diseases has stagnated over the years and that diseases with a high prevalence, burden and mortality rate receive little funding. These findings demonstrate the need to strengthen the health research system by providing sustainable funding for research on neglected tropical diseases that is consistent with the population’s health needs.

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Há equidade na produção do conhecimento sobre as doenças negligenciadas no Brasil?

Cited by 4 publications

References 5 publications

Active Essential Oils and Their Components in Use against Neglected Diseases and Arboviruses

Active Essential Oils and Their Components in Use against Neglected Diseases and Arboviruses

Sickle Cell Disease in Bahia, Brazil: The Social Production of Health Policies and Institutional Neglect

Evolution of research funding for neglected tropical diseases in Brazil, 2004–2020

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