H2S-mediated aerobic exercise antagonizes the hippocampal inflammatory response in CUMS-depressed mice

Liu, Ruilian; Hong-lin, QU; Xie, Jun; Jianxin, Long; Bai, Qingshun; Chen, Yilin; Mao, Haifeng

doi:10.1016/j.jad.2021.02.005

Cited by 21 publications

(19 citation statements)

References 41 publications

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“…CUMS simulates the social pressure of patients with depression. The experimental program adopts orphan rearing and 4 consecutive weeks of stress stimulation except for the control group, including: (1) water deprivation for 24 h, (2) fasting for 24 h, (3) wet litter for 24 h, (4) noise (> 80 dB) for 3 h, (5) tail-clamping for 30 min, (6) tilts the squirrel cage at 45° for 24 h, (7) swim in ice water for 5 min, (8) turn upside down day and night, (9) light up all night [13,14]. Perform 1-2 kinds of stimulation every day to ensure that the stimulation is not repeated within 3 days.…”

Section: Cums Modelmentioning

confidence: 99%

Study on Antidepressant Effect and Mechanism of Crocin Mediated by the mTOR Signaling Pathway

et al. 2022

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Crocin is a monomer of Chinese traditional herbs extracted from saffron, relieving depression-like behavior. However, its underlying mechanism of action remains unclear. Herein, we explored whether crocin's antidepressant effect depended on the mammalian target of the rapamycin (mTOR) signaling pathway. The model of PC12 cells injury was established by corticosterone, the changes in cell survival rate were tested by the CCK-8 method, and the changes in cellular morphology were observed under a fluorescence microscope. The depression model was established by chronic unpredictable mild stress (CUMS), and its antidepressant effect was estimated by open field test (OFT), forced swimming test (FST), and tail suspension test (TST). Western blot was used to monitor the protein expression. The results showed that crocin could effectively improve cell survival rate and cellular synaptic growth, alleviate the depressive behavior of CUMS mice, and promote the expression of BDNF, P-mTOR, P-ERK, and PSD95. However, when rapamycin was pretreated, the antidepressant effects of crocin were inhibited. In summary, crocin plays a significant antidepressant effect. After pretreatment with rapamycin, the anti-depression effect of crocin was significantly inhibited. It is suggested that the mechanism of the anti-depression effect of crocin may be related to the mTOR signaling pathway.

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Section: Cums Modelmentioning

confidence: 99%

Study on Antidepressant Effect and Mechanism of Crocin Mediated by the mTOR Signaling Pathway

et al. 2022

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“…In recent years, many animal experiments and clinical studies have pointed out that the pathogenesis of depression is highly related to chronic inflammation. For example, some rodent research reports ( Su et al, 2017 ; Han et al, 2018 ; Zhao J. et al, 2019 ; Ruilian et al, 2021 ) showed that central and peripheral concentrations of inflammatory factors, especially IL-1 β, IL-6, and TNF-α, increased after the depression model was established by chronic unpredictable mild stress (CUMS). Willner et al’s (2013) study on major depressive disorder (MDD) found that mild depressive symptoms (such as depression, mental anxiety, and guilt) were associated with anti-inflammatory responses (high levels of IL-4 and low levels of IL-17 and IL-2).…”

Section: The Underlying Mechanism Of Depressionmentioning

confidence: 99%

Update on the Relationship Between Depression and Neuroendocrine Metabolism

et al. 2021

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Through the past decade of research, the correlation between depression and metabolic diseases has been noticed. More and more studies have confirmed that depression is comorbid with a variety of metabolic diseases, such as obesity, diabetes, metabolic syndrome and so on. Studies showed that the underlying mechanisms of both depression and metabolic diseases include chronic inflammatory state, which is significantly related to the severity. In addition, they also involve endocrine, immune systems. At present, the effects of clinical treatments of depression is limited. Therefore, exploring the co-disease mechanism of depression and metabolic diseases is helpful to find a new clinical therapeutic intervention strategy. Herein, focusing on the relationship between depression and metabolic diseases, this manuscript aims to provide an overview of the comorbidity of depression and metabolic.

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“…In several studies, the volumes of the HC and PFC significantly decrease in patients with depression and closely correlate with depression severity 32,38,39 . In addition, the results of human and animal studies on depression have indicated the structural alterations, including reduction of spine density and atrophy and loss of neuronal cells in the HC and PFC [40][41][42][43] .…”

Section: Discussionmentioning

confidence: 99%

Exogenous melatonin alleviates neuropathic pain-induced affective disorders by suppressing NF-κB/ NLRP3 pathway and apoptosis

Mokhtari

Yue

2023

Sci Rep

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In this study, we aimed to evaluate the anti-inflammatory and anti-apoptotic effects of melatonin (MLT) on neuropathic pain (NP)-induced anxiety and depression in a rat model. Adult male rats were separated into four groups, i.e., Sham-VEH: healthy animals received a vehicle, Sham-MLT (10 mg/kg), and chronic constrictive injury (CCI)-VEH: nerve ligation received the vehicle, and CCI-MLT. Next, we used behavioral tests to evaluate pain severity, anxiety, and depression. Finally, rats were sacrificed for molecular and histopathological studies. Behavioral tests showed that NP could induce depressive- and anxiety-like behaviors. NP activated NF-κB/NLRP3 inflammasome pathways by upregulating NF-κB, NLRP3, ASC, active Caspase-1, also enhancing the concentrations of cytokines (IL-1β and IL-18) in the prefrontal cortex (PFC) and hippocampus (HC). NP upregulated Bax, downregulated Bcl2, and increased cell apoptosis in the HC and PFC. The rats treated with MLT eliminated the effects of NP, as the reduced pain severity, improved anxiety- and depressive-like behaviors, ameliorated NF-κB/NLRP3 inflammasome pathways, and modulated levels of cytokines in the HC and PFC. MLT could promote cell survival from apoptosis by modulating Bax and Bcl2. Therefore, it might be inferred that its anti-inflammatory and anti-apoptotic properties mediate the beneficial effects of MLT in NP-induced affective disorders.

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H2S-mediated aerobic exercise antagonizes the hippocampal inflammatory response in CUMS-depressed mice

Cited by 21 publications

References 41 publications

Study on Antidepressant Effect and Mechanism of Crocin Mediated by the mTOR Signaling Pathway

Study on Antidepressant Effect and Mechanism of Crocin Mediated by the mTOR Signaling Pathway

Update on the Relationship Between Depression and Neuroendocrine Metabolism

Exogenous melatonin alleviates neuropathic pain-induced affective disorders by suppressing NF-κB/ NLRP3 pathway and apoptosis

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