H1° histone and differentiation of dendritic cells. A molecular target for tumor-derived factors

Abstract

Dendritic cells (DC) play a central role in antitumor immune responses. Abnormal differentiation of DC and their inability to stimulate T cells are important factors in tumor escape from immune-system control. However, the mechanisms of this process remain elusive. Here, we have described one possible molecular mechanism that involves replacement linker histone H1°. A close association between expression of H1° and DC differentiation in vitro has been found. DC production in H1°-deficient mice was decreased significantly, whereas generation and function of macrophages, granulocytes, and lymphocytes appear to be normal. However, these mice had a significantly reduced response to vaccination with antigens. Tumor-derived factors considerably reduced h1° expression in hematopoietic progenitor cells. We have demonstrated that transcription factor NF-κB is involved actively in regulation of h1°. Thus, H1° histone may be an important factor in normal DC differentiation. Tumor-derived factors may inhibit DC differentiation by affecting H1° expression.

Differential RNA Expression Profile by cDNA Microarray in Sporadic Primary Hyperparathyroidism (pHPT): Primary Parathyroid Hyperplasia versus Adenoma

“…It has been speculated that tumor‐derived factors might inhibit normal differentiation by affecting H1 expression. This finding, in addition to the observation that hyperplasia showed a more heterogeneous and complex expression profile pattern, could address interesting questions about its neoplastic biological behavior 42…”

“…This finding, in addition to the observation that hyperplasia showed a more heterogeneous and complex expression profile pattern, could address interesting questions about its neoplastic biological behavior. 42…”

Nutriepigenomics in Environmental-Associated Oxidative Stress

“…To be noted, the deregulation of H1° histone expression can be associated with tumorigenesis [ 189 ]. Accordingly, H1° is a linker histone variant with a prominent role during terminal differentiation [ 190 , 191 ]. Moreover, studies indicated that tumor-derived factors could inhibit the expression of H1°, which will cause defective dendritic cell differentiation [ 191 ].…”

“…Accordingly, H1° is a linker histone variant with a prominent role during terminal differentiation [ 190 , 191 ]. Moreover, studies indicated that tumor-derived factors could inhibit the expression of H1°, which will cause defective dendritic cell differentiation [ 191 ]. EVs are quite stable and can be detected in serum.…”