Gynecologic Problems of Adolescence

Sanfilippo, Joseph S.; Yussman, Marvin A.

doi:10.1007/978-1-4612-5064-7_6

Cited by 9 publications

(3 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Without ovulation and subsequent progesterone production, a state of unopposed estrogen occurs, causing dilatation of the spiral arterial supply in the endometrium, and resulting in endometrial proliferation and associated abnormal height without proper structural integrity. 21 Large, thin-walled, tortuous, superficial endometrial vessels often can be demonstrated on the surface of the hyperplastic endometrium; increased fragility is a probable contributor to increased blood loss. Unopposed estrogen has a direct effect on the uterine blood supply by reducing vascular tone and possibly an indirect effect by inhibiting vasopressin release, leading to vasodilatation and increased blood flow.…”

Section: Discussionmentioning

confidence: 99%

Role of serum copper and ceruloplasmin level in patients with dysfunctional uterine bleeding

Khandhadiya

Chianeh

Rao

2014

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Role of serum copper and ceruloplasmin level in patients with dysfunctional uterine bleeding

Khandhadiya

Chianeh

Rao

2014

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

“…With no ovulation and subsequent progesterone production, results in unopposed estrogen occurs, causing dilatation of the arterial supply in the endometrium, and lead to proliferation of endometrium and would associate with abnormal thickening of the endometrium without proper architectural integrity. 16 Large, thin-walled, tortuous, superficial endometrial vessels often can be demonstrated on the surface of the endometrial hyperplasia; increase of blood loss is due to fragility of blood vessels. Vascular tone would reduce by an unopposed estrogen and has a direct effect by inhibiting vasopressin release, that causes vasodilatation and increase blood.…”

Section: Hormonal Regulationmentioning

confidence: 99%

Molecular and hormonal regulation of angiogenesis in proliferative endometrium

Chianeh

Rao

2014

Int J Res Med Sci

View full text Add to dashboard Cite

Angiogenesis is a hallmark of wound healing, the menstrual cycle, cancer, and various ischemic and inflammatory diseases. A rich variety of pro and anti-angiogenic molecules have already been identified. Vascular endothelial growth factor (VEGF) is an interesting inducer of angiogenesis and lymphangiogenesis, because it is a highly specific mitogen for endothelial cells. Signal transduction involves binding to tyrosine kinase receptors and results in endothelial cell proliferation, migration, and new vessel formation. In this article, the role of VEGF and other growth factors in the pathology of dysfunctional uterine bleeding is reviewed. We also discuss the role of VEGF expression and interaction with extracellular matrix that lead to possible inhibition or stimulation of Angiogenic factor on endometrium of dysfunctional uterine bleeding patients.

show abstract

“…Organic etiologies of DUB include coagulation defects, pathology involving the reproductive tract infections, systemic diseases, trauma, and iatrogenic causes. DUB is a diagnosis of exclusion, 1 and thus systemic disease and local lesions must be ruled out first. It is usually secondary to anovulation.…”

Section: Introductionmentioning

confidence: 99%

Dysfunctional Uterine Bleeding

Deligeoroglou

1997

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

Dysfunctional uterine bleeding (DUB) is a frequent gynecological problem during adolescence and the most frequent cause of urgent admission to the hospital over this period of life. In about 95% of cases it is caused by the late maturation of the hypothalamic-pituitary-ovarian axis (HPO), leading to anovulatory cycles. These adolescents lack the E2 positive feedback on LH. Thus, the continuous production of estrogen with endometrial stimulation is the basic cause of dysfunctional uterine bleeding. The initial step in the evaluation of DUB includes detailed clinical history, followed by complete physical examination. Laboratory tests should include coagulation profile, complete blood count with platelet evaluation, and sometimes a serum pregnancy test. The treatment of DUB is related to the severity of symptomatology with the objective of stopping bleeding and preventing recurrences. Modern hormonal and other medical therapies enable physicians to treat DUB effectively, regardless of the cause. Surgical treatment, such as dilatation and curettage, is rarely indicated in the adolescent patient. The importance of continued follow-up in DUB cases should be underlined, until stabilization of ovulatory menstrual cycles.

show abstract

Gynecologic Problems of Adolescence

Cited by 9 publications

References 81 publications

Role of serum copper and ceruloplasmin level in patients with dysfunctional uterine bleeding

Role of serum copper and ceruloplasmin level in patients with dysfunctional uterine bleeding

Molecular and hormonal regulation of angiogenesis in proliferative endometrium

Dysfunctional Uterine Bleeding

Contact Info

Product

Resources

About