Guttural pouch leiomyosarcoma causing nasopharyngeal compression in a pony

Drew, Steve; Meehan, L.; Reardon, Richard; McGorum, Bruce; Dixon, Padraic; Del-Pozo, Jorge

doi:10.1111/eve.12607

Cited by 7 publications

(7 citation statements)

References 21 publications

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“…IHC is an important diagnostic tool in determining the cellular origin of neoplasms because of its practicality, high sensitivity, and specificity when compared to other diagnostic methods (WILSON, 2017). In the evaluated sections, there was moderate and diffuse cytoplasmic reactivity in the neoplastic cells for the antibodies against desmin, 1A4, and HHF35, thus confirming the muscular origin and specifying the smooth muscle type using markers 1A4 and HHF35, given that the latter markers are specific for alpha-smooth muscle actin (DREW et al, 2016;GRACCHI et al, 2020).…”

Section: Discussionmentioning

confidence: 69%

Nasal leiomyosarcoma in a Quarter Horse

et al. 2023

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We described the clinical and anatomopathological findings observed in a case of nasal leiomyosarcoma in a five-year-old male Quarter Mile horse, whose main complaints were decreased sports performance and bilateral purulent nasal discharge. The nodule was observed in the nasal cavity, obstructing the left nostril and associated with purulent drainage. The nodule was of irregular shape and yellow color, measuring 19.4 cm × 6.9 cm × 4.3 cm in size, with coalescent multifocal areas that were brownish, friable, opaque, and fetid. When cut, the surface was compact, grayish-white, and smooth with yellow, friable, irregular multifocal areas, measuring 1-3.2 cm in diameter. Histopathological examination showed spindle-shaped neoplastic cells, which was negative on Masson’s trichromic stain. A diagnosis of leiomyosarcoma was established based on the morphotintorial aspects of neoplastic cells and confirmed through immunohistochemistry, with positive immunostaining for antibodies 1A4, HHF35, desmin, and S100. Leiomyosarcoma primarily affects the nasal cavity of horses and should be included in the differential diagnosis of diseases that affect the nasal cavity and cause nasal obstruction associated with dyspnea.

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Section: Discussionmentioning

confidence: 69%

Nasal leiomyosarcoma in a Quarter Horse

et al. 2023

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“…The larynx and other perioesophageal tissues also cannot be excluded as the site of origin; however, this would point towards the presence of a leiomyosarcoma with local invasion rather than a benign leiomyoma. A leiomyosarcoma has recently been reported within the caudal aspect of the guttural pouch (Drew et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Leiomyoma of the proximal cervical oesophagus in a horse

Faulkner

Vlaminck

Geerinckx

et al. 2022

Equine Veterinary Education

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Summary An 18‐year‐old female Fjord horse presented with a history of recent progressive dysphagia, coughing and increased respiratory effort during exercise, which had not improved with administration of systemic antimicrobials. Upper airway endoscopy, radiography and computed tomography showed a soft tissue mass at the dorsal aspect of the larynx in the region of the proximal cervical oesophagus. Humane euthanasia was opted for and post‐mortem, histological and immunohistochemical examination provided a definitive diagnosis of leiomyoma of the proximal oesophagus. Neoplasia, and more specifically a smooth muscle neoplasm, of the proximal cervical oesophagus has not previously been reported in horses.

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“…Hematomas can occur in some cases of trauma, especially to adjacent musculature. Neoplasia involving the guttural pouch is uncommon but cases of fibroma, melanoma, squamous cell carcinoma, hemangiosarcoma and leiomyosarcoma have been described [ 5 , 13 , 21 ]. A case of a large fungal granuloma secondary to guttural pouch mycosis was also reported [ 22 ].…”

Section: Imaging Features Of Diseases Affecting the Guttural Pouchmentioning

confidence: 99%

“…Diagnostic imaging is particularly useful for evaluation of large masses obliterating the pouches because endoscopy may not be possible in these cases and diagnostic imaging provides a better evaluation of the structures surrounding the pouches. Radiographic examination may reveal an increased soft tissue opacity obliterating the air-filled guttural pouch, with a mass effect displacing its contours [ 5 , 21 ]. The contours of the pouch can be compressed if the mass is originating from surrounding structures, or expanded if the mass is located within the pouches [ 5 ].…”

Section: Imaging Features Of Diseases Affecting the Guttural Pouchmentioning

confidence: 99%

Diagnostic Imaging of Diseases Affecting the Guttural Pouch

Thomas‐Cancian

Ségard‐Weisse

Drumond

et al. 2023

Veterinary Sciences

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The most common diseases of the guttural pouch are empyema, tympany, mycosis and temporohyoid osteoarthropathy. The challenge in diagnosis of guttural pouch diseases lies in the complex anatomy of the guttural pouch and adjacent associated structures. Diagnostic imaging is a good complement to endoscopy for the diagnosis of some guttural pouch diseases, especially to make a full assessment of the lesions involving the pouch and surrounding structures. This review article describes the value of each diagnostic imaging technique in the diagnosis of guttural pouch disease and the corresponding imaging findings. Radiography is generally used as the first line to complement endoscopic findings, and can give useful additional information although it is limited by superimposition. Ultrasonographic examination of the guttural pouch is of limited value due to the presence of gas in the guttural pouch but can eventually be used to detect fluid within the pouch or can help to evaluate the soft tissues located lateral and ventral to the guttural pouch. Cross-sectional imaging, especially CT, is increasingly available and appears to be the best technique to fully assess the surrounding soft tissues and to precisely identify lesions of the temporohyoid apparatus, temporal bone and skull base that are associated with guttural pouch disease.

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Guttural pouch leiomyosarcoma causing nasopharyngeal compression in a pony

Cited by 7 publications

References 21 publications

Nasal leiomyosarcoma in a Quarter Horse

Nasal leiomyosarcoma in a Quarter Horse

Leiomyoma of the proximal cervical oesophagus in a horse

Diagnostic Imaging of Diseases Affecting the Guttural Pouch

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