Gut Microbiota, Diet, and Chronic Diseases: The Role Played by Oxidative Stress

Vasquez, Elisardo C.; Pereira, Thiago de Melo Costa; Campos‐Toimil, Manuel; Baldo, Marcelo Perim; Peotta, Veronica A.

doi:10.1155/2019/7092032

Cited by 11 publications

(12 citation statements)

References 10 publications

(8 reference statements)

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“…141 These preclinical studies set the stage for studies in humans. An initial study reported that AST-120 decreased serum levels of indoxyl sulphate in a dose-dependent manner in Inflammatory cytokines 45,47 Inflammatory cytokines 145 Oxidative stress 13 Oxidative stress 146 Indoxyl-sulphate 72,77,81,83 P-cresyl-sulphate 71,81,82 BMPs 13 Secondary CPPs 43 Serum calcium 13,19 Serum phosphate 13,19 Serum Ca-P product 13,19 Serum PTH 13,41 Serum FGF-23 13 patients with moderate to severe CKD. 142 This was followed by a more recent large, multinational, randomized clinical trial that unfortunately could not show a beneficial effect of AST-120 on the progression of CKD.…”

Section: Interventionsmentioning

confidence: 99%

Interplay between gut microbiota, bone health and vascular calcification in chronic kidney disease

Rodrigues

Ormanji

Heilberg

et al. 2021

Eur J Clin Investigation

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Section: Interventionsmentioning

confidence: 99%

Interplay between gut microbiota, bone health and vascular calcification in chronic kidney disease

Rodrigues

Ormanji

Heilberg

et al. 2021

Eur J Clin Investigation

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“…Gut microbiota and intestinal barrier are strongly related to maintaining homeostasis in intestine as well as other organs of host (Dam et al, 2019). Disordered gut microbiota can produce excessive ROS to induce oxidative stress that in turn lead to intestinal inflammation and even various chronic diseases related to inflammation (Marciano and Vajro, 2017;Vasquez et al, 2019). However, some gut microbial metabolites, such as SCFAs, are able to alleviate oxidative stress (Andrade-Oliveira et al, 2015;Rose et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

D-Galactose Induces Chronic Oxidative Stress and Alters Gut Microbiota in Weaned Piglets

et al. 2021

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Oxidative stress commonly occurs in pig production, which can severely damage the intestinal function of weaned piglets. This study was conducted to investigate the effects of D-galactose with different levels used to induce chronic oxidative stress on growth performance, intestinal morphology and gut microbiota in weaned piglets. The results showed that addition of 10 and 20 g/kg BW D-galactose reduced average daily gain and average daily feed intake from the first to the third week. 10 g/kg BW D-galactose increased the concentration of serum MDA at the second and third week. 10 g/kg BW D-galactose significantly influenced the jejunal and ileal expressions of GPx1, CAT1, and MnSOD. The results of 16S rRNA sequencing showed that compared with the control, 10 and 20 g/kg BW D-galactose significantly decreased the relative abundance of Tenericutes, Erysipelotrichia, Erysipelotrichales, and Erysipelotrichaceae, while increased the relative abundance of Negativicutes, Selenomonnadales, and Veillonellaceae. The results indicated that treatment with 10 g/kg BW/day D-galactose for 3 weeks could induce chronic oxidative stress, reduce the growth performance and alter gut microbiota in weaned piglets.

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“…Therefore, these mechanisms appear to contribute to the vulnerability of the central nervous system, as elicited by oxidative stress and are susceptible to degenerative processes. More recently, studies have revealed that complex microbiota–host cross-talk could also play a modulatory role in oxidative stress in the central nervous system through direct and indirect (such as lipopolysaccharides, amyloid proteins, or antibiotics) pathways, which can reach the brain through circulation or the vagus nerve, activating microglia to overproduce ROS [ 87 , 100 ]. Thus, the microbiota–gut–brain axis has been an “open gate” for new therapeutic strategies for several neurological conditions, as described in the next sections.…”

Section: Lessons On How To Fight Oxidative Stressmentioning

confidence: 99%

The Emerging Scenario of the Gut–Brain Axis: The Therapeutic Actions of the New Actor Kefir against Neurodegenerative Diseases

et al. 2021

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The fact that millions of people worldwide suffer from Alzheimer’s disease (AD) or Parkinson’s disease (PD), the two most prevalent neurodegenerative diseases (NDs), has been a permanent challenge to science. New tools were developed over the past two decades and were immediately incorporated into routines in many laboratories, but the most valuable scientific contribution was the “waking up” of the gut microbiota. Disturbances in the gut microbiota, such as an imbalance in the beneficial/pathogenic effects and a decrease in diversity, can result in the passage of undesired chemicals and cells to the systemic circulation. Recently, the potential effect of probiotics on restoring/preserving the microbiota was also evaluated regarding important metabolite and vitamin production, pathogen exclusion, immune system maturation, and intestinal mucosal barrier integrity. Therefore, the focus of the present review is to discuss the available data and conclude what has been accomplished over the past two decades. This perspective fosters program development of the next steps that are necessary to obtain confirmation through clinical trials on the magnitude of the effects of kefir in large samples.

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Gut Microbiota, Diet, and Chronic Diseases: The Role Played by Oxidative Stress

Cited by 11 publications

References 10 publications

Interplay between gut microbiota, bone health and vascular calcification in chronic kidney disease

Interplay between gut microbiota, bone health and vascular calcification in chronic kidney disease

D-Galactose Induces Chronic Oxidative Stress and Alters Gut Microbiota in Weaned Piglets

The Emerging Scenario of the Gut–Brain Axis: The Therapeutic Actions of the New Actor Kefir against Neurodegenerative Diseases

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